Can Custom-Tailored brain zaps beat tough depression?
NCT ID NCT06112652
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 days, with each session's target personalized using brain scans. The goal is to find the best dose to reduce depression scores.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive transcranial magnetic stimulation (rTMS) guided by personalized brain functional sectors
What this could lead to
If successful, this could point toward a more effective, personalized rTMS dosing strategy for people with hard-to-treat depression.
What could go wrong
This trial is early-stage and currently suspended. The optimal dose is unknown, and results may not apply to all depression patients. Side effects like headache or scalp discomfort are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Wuhan Mental Health Center
Wuhan, China