Can Custom-Tailored brain zaps beat tough depression?

NCT ID NCT06112652

Terminated Symptom relief Sponsor: Changping Laboratory Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 days, with each session's target personalized using brain scans. The goal is to find the best dose to reduce depression scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS) guided by personalized brain functional sectors
What this could lead to: If successful, this could point toward a more effective, personalized rTMS dosing strategy for people with hard-to-treat depression.
What could go wrong: This trial is early-stage and currently suspended. The optimal dose is unknown, and results may not apply to all depression patients. Side effects like headache or scalp discomfort are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER MODERATE DEPRESSION SEVERE DEPRESSION

Contacts and locations

Locations

Wuhan Mental Health Center

Wuhan, China

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