Could an arthritis drug help treat schizophrenia?
NCT ID NCT05622201
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether rituximab, an anti-inflammatory drug used for conditions like multiple sclerosis, can improve symptoms in adults with schizophrenia spectrum disorders. About 123 participants aged 18-55 will receive rituximab or a placebo added to their usual treatment. The study also looks at blood markers and brain scans to understand who might benefit.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- rituximab
- What this could lead to
- If it works, this could point toward a new treatment option for some people with schizophrenia by targeting inflammation.
- What could go wrong
- This is a small, early-phase trial. Rituximab is not proven for psychosis, and results may not apply to everyone. Side effects from immune suppression are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Örebro university hospital
Örebro, Örebro County, 701 85, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Spotting psychosis early could change lives — a major study tests whether faster treatment leads to better recovery
- Immune clues in schizophrenia: could inflammation subtypes guide treatment?
- Brain training from home: could a smartphone app sharpen thinking in early psychosis?
- Can a smartphone help silence distressing voices? online self-help program tested for psychosis
- Virtual reality therapy could help psychosis patients tame overwhelming emotions
- Brain zaps show promise for silencing hallucinations