Two brain zaps may lift the fog of Schizophrenia's negative symptoms
NCT ID NCT07680959
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This trial investigates whether combining two types of brain stimulation—intermittent theta burst stimulation (iTBS) and high-definition transcranial direct current stimulation (HD-tDCS)—can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal, and reduced emotional expression. The study enrolls 100 adults with schizophrenia or schizoaffective disorder who have stable but prominent negative symptoms. Participants receive active or sham stimulation over three weeks, and researchers track symptom changes using standard rating scales immediately after treatment and at one and three months later.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
brain stimulation (iTBS and HD-tDCS)
What this could lead to
If it works, this could offer a new way to reduce negative symptoms of schizophrenia, improving daily functioning and quality of life.
What could go wrong
This is an early-stage trial with 100 participants, so results may not apply to everyone. Brain stimulation can cause mild side effects like headache or scalp discomfort.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ublituximab for Schizophrenia Trial (NCT07680946)
- Sleep Brain Stimulation Study for Schizophrenia NCT07680114
- Digital Cognitive Training for Schizophrenia (NCT07674914)
- TV-44749 Schizophrenia Trial (NCT06253546)
- Schizoaffective Disorder Biomarker Study NCT07673718
- Cognitive Training for Older Adults with Schizop NCT07658391
Contacts and locations
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Locations
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Tri-service general hospital
Taipei, 114, Taiwan