New pill RAP-219 aims to tame mania in bipolar disorder
NCT ID NCT07046494
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently experiencing a manic episode. About 250 participants will receive either RAP-219 or a placebo daily for 21 days. Researchers will measure changes in manic symptoms using a standard rating scale to see if the drug is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RAP-219 (oral tablet)
What this could lead to
If it works, this could provide a new short-term treatment option to quickly reduce manic symptoms in people with bipolar I disorder.
What could go wrong
This is an early Phase 2 trial with only 250 participants, so results may not apply to everyone. The drug may prove no better than placebo, and side effects are still being studied.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arch Clinical Trials
RECRUITINGSt Louis, Missouri, 63125, United States
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CNRI - San Diego, LLC
WITHDRAWNSan Diego, California, 92123, United States
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CenExel - Decatur
RECRUITINGDecatur, Georgia, 30030, United States
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CenExel - Gaithersburg
ACTIVE_NOT_RECRUITINGGaithersburg, Maryland, 20877, United States
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CenExel - Hollywood
RECRUITINGHollywood, Florida, 33024, United States
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Collaborative Neuroscience Research - Los Alamitos
RECRUITINGLos Alamitos, California, 90720, United States
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Community Clinical Research, Inc.
RECRUITINGAustin, Texas, 78754, United States
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HD Research - Memorial Hermann Village
ACTIVE_NOT_RECRUITINGHouston, Texas, 77043, United States
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Inland Psychiatric Medical Group - Chino
ACTIVE_NOT_RECRUITINGChino, California, 91710, United States
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NRC Research Institute - Orange
RECRUITINGOrange, California, 92868, United States
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NeuroBehavioral Hospitals of the Palm Beaches - South
RECRUITINGBoynton Beach, Florida, 33426, United States
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Neuroscience Research Institute at Ambrosia
RECRUITINGWest Palm Beach, Florida, 33407, United States
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New Hope Clinical Research
RECRUITINGCharlotte, North Carolina, 28211, United States
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Pillar Clinical Research - Chicago
RECRUITINGChicago, Illinois, 60641, United States
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Pillar Clinical Research - Little Rock
RECRUITINGLittle Rock, Arkansas, 72204, United States
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Pillar Clinical Research - Richardson
ACTIVE_NOT_RECRUITINGRichardson, Texas, 75080, United States
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Richmond Behavioral Associates
RECRUITINGStaten Island, New York, 10314, United States
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Segal Trials - Miami Lakes Medical Research Early Phase, Inpatient & Outpatient Site
RECRUITINGMiami Lakes, Florida, 33016, United States
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Synergy Clinical Research Center - San Diego
RECRUITINGLemon Grove, California, 91945, United States
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United Research Institute
RECRUITINGHialeah, Florida, 33012, United States
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Woodland International Research Group
WITHDRAWNLittle Rock, Arkansas, 72211, United States
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Woodland Research Northwest
RECRUITINGRogers, Arkansas, 72758, United States
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