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New depression pill CYB003 enters final testing phase

NCT ID NCT06564818

Ongoing Symptom relief Sponsor: Cybin IRL Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • Adams Clinical

    Boston, Massachusetts, 02472, United States

  • Adams Clinical Boston

    Boston, Massachusetts, 02116, United States

  • Adams Clinical Bronx

    The Bronx, New York, 10461, United States

  • Adams Clinical Harlem

    New York, New York, 100029, United States

  • Adams Clinical Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Atlanta Center for Medical Research, CenExel

    Atlanta, Georgia, 30331, United States

  • Bespoke Treatment/Lipov Medical Group

    Los Angeles, California, 90025, United States

  • Catalina Research Institute

    Montclair, California, 91763, United States

  • Cedar Clinical Research

    Murray, Utah, 84107, United States

  • CenExel CIT (Clinical Innovations, Inc)

    Bellflower, California, 90706, United States

  • CenExel iResearch Atlanta

    Decatur, Georgia, 30330, United States

  • CenExel iResearch Savannah

    Savannah, Georgia, 31405, United States

  • Charter Research

    Orlando, Florida, 32803, United States

  • Clinical Neuroscience Solutions, CNS Healthcare

    Memphis, Tennessee, 38119, United States

  • Clinical Neuroscience Solutions, Inc

    Orlando, Florida, 32801, United States

  • Combined Research Orlando Phase I-IV

    Orlando, Florida, 32807, United States

  • Del Sol Research Management

    Tucson, Arizona, 85715, United States

  • DelRicht Research

    New Orleans, Louisiana, 70115, United States

  • Elixia Health

    Springfield, Massachusetts, 01103, United States

  • Excell Research, Inc

    Oceanside, California, 92056, United States

  • Floridian Neuroscience Institute

    Miami, Florida, 33135, United States

  • Global Medical Institutes, Princeton Medical Institute

    Princeton, New Jersey, 08540, United States

  • Great Lakes Clinical Trials, DBA Flourish Research

    Chicago, Illinois, 60640, United States

  • InSite Clinical Research, LLC

    DeSota, Texas, 75115, United States

  • Inland Psychiatric Medical Group Inc

    San Juan Capistrano, California, 92675, United States

  • Inner Space Research, LLC

    Orem, Utah, 84058, United States

  • K2 Medical Research - Tampa

    Tampa, Florida, 33634, United States

  • K2 Medical Research-Maitland

    Maitland, Florida, 32751, United States

  • Kadima Neuropsychiatry Institute

    La Jolla, California, 92037, United States

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • Mountain Clinical Trials

    Phoenix, Arizona, 85050, United States

  • Mountain View Clinical Research

    Denver, Colorado, 80209, United States

  • Neurobehavioral Clinical Research

    North Canton, Ohio, 44720, United States

  • Noble Clinical Research

    Tucson, Arizona, 85704, United States

  • Oasis Clinical Trials

    Las Vegas, Nevada, 89121, United States

  • Open Mind Therapeutics

    San Francisco, California, 94114, United States

  • Psychiatric Medicine Associates, LLC

    Skokie, Illinois, 60076, United States

  • Redbird Research, LLC

    Las Vegas, Nevada, 89119, United States

  • Research Centers of America

    Hollywood, Florida, 33024, United States

  • Scottsdale Research Institute

    Phoenix, Arizona, 85022, United States

  • Segal Trials West Broward

    North Miami, Florida, 33161, United States

  • Starlight Clinical Research

    Evergreen, Colorado, 80439, United States

  • Sunstone Medical, PC

    Rockville, Maryland, 20850, United States

  • Uptown Research Institute

    Chicago, Illinois, 60640, United States

  • Zillan Clinical Research

    Houston, Texas, 77433, United States

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