Could a facial zapping device treat depression at home?

NCT ID NCT06261177

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, with a secondary look at whether it improves mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Functional Electrical Stimulation (FES) device

What this could lead to

If it works, this could point toward a new, non-drug treatment option for depression that people can use at home.

What could go wrong

This is a very small, early feasibility study with only 20 people. It is designed to test if the approach is practical and safe, not yet to prove it works for depression.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MDD are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

endogenous depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St. Michael's Hospital

    Toronto, Ontario, Canada