Unity Health Toronto

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study looks at two common surgeries for hip fractures in people aged 60 and older: one uses plates and screws to fix the bone, and the other replaces the hip joint. The goal is to see which approach leads to less pain and better movement. About 104 participants will be follo…

This study tests whether tranexamic acid (TXA), a cheap drug that prevents blood clots from breaking down, can help people recover from a subdural hematoma—a collection of blood on the brain after a head injury. About 130 adults aged 45 and older with symptoms like headache or co…

This study compares two surgeries for a broken thigh bone near the knee in people aged 65 and older: replacing the damaged knee with an artificial joint (distal femoral replacement) or fixing the bone with plates and screws (ORIF). The goal is to see which approach leads to bette…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study tests whether frequent, short virtual visits with diabetes educators can help adults with type 1 diabetes improve their blood sugar control. 580 participants will receive video check-ins every 1-3 weeks for 6 months, plus access to online education tools. The goal is t…

This study tests whether giving a healthy food voucher to people with type 2 diabetes or prediabetes who have low income can improve their blood sugar control. About 390 participants will be randomly assigned to receive the voucher or not. The main goal is to see if hemoglobin A1…

This study tests whether setting a breathing machine based on each patient's lung mechanics can lower the chance of death within 60 days for people with acute respiratory distress syndrome (ARDS). It includes both COVID-19 and non-COVID-19 patients. The approach is compared to st…

This study looks at two ways to treat a broken thigh bone near a knee replacement in people 65 and older. One option is to fix the bone with plates and screws. The other is to replace the whole knee joint with an artificial one. The goal is to see which surgery leads to less pain…

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to…

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with intensive therapy can help people with chronic posttraumatic stress disorder (PTSD). Fifteen adults with moderate to severe PTSD will receive the treatment over a week. T…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee…

This pilot study tests whether a single dose of MDMA (ecstasy) combined with psychological support can help people with severe chronic neuropathic pain. Forty adults with moderate-to-severe nerve pain will receive either MDMA or a placebo (methylphenidate) along with psychotherap…

This study tests a single 90-minute therapy session called Brief Skills for Safer Living (Brief-SfSL) to see if it can reduce suicidal thoughts in adults. Researchers will enroll 150 participants across Canada, with half receiving the therapy immediately and the other half after …

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study tests a safe, non-invasive light therapy device (Neuro RX Gamma) in 60 adults aged 50+ with mild cognitive impairment due to Alzheimer's. The treatment uses near-infrared light to stimulate brain areas linked to memory. Researchers will check if it improves thinking, d…

This study tests a digital app called the Genetics Adviser for Mainstream Care (GA-Mainstream) that educates cancer patients about genetic testing and delivers their results. Researchers want to see if using the app reduces distress and improves the patient experience compared to…

This study is testing a digital platform called the Genetics Navigator to see if it can reduce distress for people undergoing genetic testing. The platform provides education, counseling, and management recommendations. Researchers will compare it to standard care in 170 adults a…

This pilot study is testing a comprehensive 18-month support program for young people aged 18-24 who are transitioning out of homelessness in Ontario, Canada. The program includes job placement, housing funds, grocery help, a community connections worker, coaching, and group sess…

This study looks at how the AbClo device, a non-invasive abdominal binder used to keep the abdomen closed after surgery, affects lung function in 18 intensive care patients on ventilators. Researchers will measure lung pressure and volume before and after adjusting the device to …

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and heal…