Could less epinephrine save more lives in cardiac arrest?

NCT ID NCT03826524

Recruiting now Disease control Sponsor: Unity Health Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to hospital discharge.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epinephrine (Adrenaline)
What this could lead to: If successful, this could show that using less epinephrine during cardiac arrest is just as effective, potentially reducing side effects and improving survival.
What could go wrong: This is a Phase 4 trial, but results may not apply to all cardiac arrest cases. Lower doses might be less effective in some patients, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Death, Sudden, Cardiac Out-of-Hospital Cardiac Arrest sudden cardiac arrest ventricular fibrillation ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST, OUT-OF-HOSPITAL SUDDEN CARDIAC ARREST VENTRICULAR FIBRILLATION VENTRICULAR TACHYCARDIA-PULSELESS

Contacts and locations

Locations

British Columbia Emergency Health Services (BCEHS)
RECRUITING

Victoria, British Columbia, V8W 9P1, Canada
Essex-Windsor Emergency Health Services
RECRUITING

Windsor, Ontario, N9A 1N6, Canada
Halton Region Paramedic Services
RECRUITING

Oakville, Ontario, L6M 3L1, Canada
Medavie Health Services West
RECRUITING

Saskatoon, Saskatchewan, S7J 4M2, Canada
Middlesex-London Paramedic Service
RECRUITING

London, Ontario, N6E 1R4, Canada
Ottawa Paramedic Services
RECRUITING

Ottawa, Ontario, K1H 1E2, Canada
Peel Regional Paramedic Services
RECRUITING

Brampton, Ontario, L6T 4B9, Canada
Superior North Emergency Medical Services
RECRUITING

Thunder Bay, Ontario, P7B 4X6, Canada

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