Could less epinephrine save more lives in cardiac arrest?
NCT ID NCT03826524
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to hospital discharge.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Epinephrine (Adrenaline)
What this could lead to
If successful, this could show that using less epinephrine during cardiac arrest is just as effective, potentially reducing side effects and improving survival.
What could go wrong
This is a Phase 4 trial, but results may not apply to all cardiac arrest cases. Lower doses might be less effective in some patients, and the study is still recruiting.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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British Columbia Emergency Health Services (BCEHS)
RECRUITINGVictoria, British Columbia, V8W 9P1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essex-Windsor Emergency Health Services
RECRUITINGWindsor, Ontario, N9A 1N6, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Halton Region Paramedic Services
RECRUITINGOakville, Ontario, L6M 3L1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medavie Health Services West
RECRUITINGSaskatoon, Saskatchewan, S7J 4M2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Middlesex-London Paramedic Service
RECRUITINGLondon, Ontario, N6E 1R4, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ottawa Paramedic Services
RECRUITINGOttawa, Ontario, K1H 1E2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peel Regional Paramedic Services
RECRUITINGBrampton, Ontario, L6T 4B9, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Superior North Emergency Medical Services
RECRUITINGThunder Bay, Ontario, P7B 4X6, Canada
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••