Unity Health Toronto

This study compares two surgeries for a broken thigh bone just above the knee in people aged 65 and older. One surgery uses metal plates and screws to hold the bone together while it heals, but often requires weeks of limited movement. The other is a knee replacement that lets pa…

This study tests whether setting a breathing machine based on each patient's lung stiffness and breathing effort can lower the chance of death within 60 days for people with acute respiratory distress syndrome (ARDS). About 740 adults with moderate to severe ARDS, including those…

This study tests whether giving vouchers for healthy foods can help people with type 2 diabetes or prediabetes who have low incomes lower their blood sugar. About 390 participants will receive vouchers or standard care. The main goal is to see if blood sugar levels improve over t…

This study looks at whether giving trauma patients whole blood before they reach the hospital works better than giving separate blood parts (red cells and plasma). About 60 adults with severe bleeding from injury will take part. The goal is to see if whole blood is easier to carr…

This study looks at two ways to treat a broken thigh bone near a knee replacement in people 65 and older. One option is to fix the bone with plates and screws. The other is to replace the knee joint with an artificial one. The goal is to see which surgery leads to less pain and b…

This study looks at whether giving a lower total amount of epinephrine during resuscitation from cardiac arrest helps more people survive to leave the hospital. About 3,790 adults whose heart stops due to a shockable rhythm will be randomly assigned to receive either a low or sta…

This study looks at two common surgeries for broken hips in people aged 60 and older: one uses plates and screws to fix the bone, and the other replaces the hip joint. The goal is to see which approach leads to less pain and better movement. About 104 participants will be followe…

This study is checking if a new finger-prick test for HIV and syphilis is easy and accurate enough for people to use on themselves at home. About 900 adults in Canada will try the test and compare results with standard lab tests. The study also looks at how peer support can help …

This study tests if Lemborexant, a sleep medication, can help adults with depression who still have insomnia despite treatment. About 30 participants will take either Lemborexant or a placebo daily for 6 weeks, tracking sleep and symptoms. The goal is to see if the drug improves …

This study tests whether giving a steroid injection to the knee that is not being operated on can reduce pain and improve function for people undergoing total knee replacement. About 60 adults with knee osteoarthritis will receive either the injection or a placebo before surgery.…

This study tests a non-invasive light therapy device (Neuro RX Gamma) for people with mild cognitive impairment (MCI) due to Alzheimer's disease. About 60 adults aged 50 and older will receive near-infrared light to specific brain areas. The goal is to see if it safely improves m…

This small pilot study is testing whether a single dose of MDMA (ecstasy), combined with talk therapy, can safely reduce severe chronic nerve pain. Forty adults with long-lasting nerve pain will receive either MDMA or a placebo during a therapy session, followed by more therapy s…

This study tests a new, one-session therapy called Brief Skills for Safer Living to see if it can reduce suicidal thoughts in adults. 150 people across Canada will take part, with half receiving the therapy right away and the other half after a 3-month wait. The study measures ch…

This study tests whether a virtual program with short video visits and online education can help adults with type 1 diabetes improve their blood sugar levels. Participants will have frequent, brief check-ins with diabetes educators from home, plus access to online classes and too…

This study tests a 12-week therapy program that combines coping skills with trauma-focused care to help adults who had traumatic childhoods and are currently thinking about suicide. The goal is to see if this approach reduces suicidal thoughts and is practical and acceptable for …

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study tests a program that provides job placement, housing help, food support, coaching, and community connections to young people aged 18-24 who are moving out of homelessness. The goal is to see if the program is practical and helpful. Researchers will track how many youth…

This study aims to understand why some people with depression do not get better with standard medications. Researchers will use brain scans to compare dopamine receptors in three groups: people with treatment-resistant depression, those whose depression responds to treatment, and…

This study looks at how a device called AbClo, which gently holds the belly together after surgery, affects breathing in patients whose abdomen is left open. Researchers will measure lung pressure and volume before and after adjusting the device, and again after the abdomen is cl…

This study tests a digital platform called the Genetics Navigator that helps patients and parents of children get genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults referred for genetic testing at two h…