Ecstasy pills tested as breakthrough treatment for untreatable pain

This small pilot study is testing whether MDMA (commonly known as ecstasy), combined with psychotherapy, can help people with severe, treatment-resistant nerve pain. Forty adults with long-term, debilitating pain will receive either MDMA or an active placebo during a guided therapy session, followed by several weeks of integration therapy. The main goal is to see if this approach is safe and feasible to study in a larger trial, while also checking if it meaningfully reduces pain and improves daily life after 16 weeks.