Gene therapy targets chronic nerve pain in new trial
NCT ID NCT06980948
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a one-time gene therapy called ST-503 for people with chronic pain from small fiber neuropathy that hasn't improved with standard treatments. The therapy aims to block pain signals before they reach the brain. The trial involves 27 adults and compares the gene therapy to a sham procedure to check safety and pain relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ST-503 gene therapy
What this could lead to
If it works, this could provide a new way to manage chronic pain that hasn't responded to other treatments.
What could go wrong
This is an early-phase trial with only 27 people, so it's too soon to know if it's safe or effective. Gene therapies can have unexpected side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Columbia University Irving Medical Center (CUIMC) and New York-Presbyterian Hospital (NYPH)
RECRUITINGNew York, New York, 10027, United States
Contact Email: •••••@•••••
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Dartmouth Hitchcock Medical Center
NOT_YET_RECRUITINGLebanon, New Hampshire, 03766, United States
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HonorHealth
RECRUITINGScottsdale, Arizona, 85260, United States
Contact Email: •••••@•••••
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21218, United States
Contact Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Email: •••••@•••••
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The University of California, San Diego
NOT_YET_RECRUITINGLa Jolla, California, 92093, United States
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University of Arkansas for Medical Sciences
RECRUITINGLittle Rock, Arkansas, 72205, United States
Contact Email: •••••@•••••
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University of North Carolina Medical Center
NOT_YET_RECRUITINGChapel Hill, North Carolina, 27514, United States
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University of Utah
NOT_YET_RECRUITINGSalt Lake City, Utah, 84112, United States
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Vanderbilt University
NOT_YET_RECRUITINGNashville, Tennessee, 37235, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
Contact Email: •••••@•••••