Gene therapy targets chronic nerve pain in new trial

NCT ID NCT06980948

Recruiting now Disease control Sponsor: Sangamo Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a one-time gene therapy called ST-503 for people with chronic pain from small fiber neuropathy that hasn't improved with standard treatments. The therapy aims to block pain signals before they reach the brain. The trial involves 27 adults and compares the gene therapy to a sham procedure to check safety and pain relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ST-503 gene therapy
What this could lead to: If it works, this could provide a new way to manage chronic pain that hasn't responded to other treatments.
What could go wrong: This is an early-phase trial with only 27 people, so it's too soon to know if it's safe or effective. Gene therapies can have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuropathy, small fiber primary erythermalgia Small Fiber Neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC NEUROPATHIC PAIN

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Columbia University Irving Medical Center (CUIMC) and New York-Presbyterian Hospital (NYPH)
RECRUITING

New York, New York, 10027, United States
Dartmouth Hitchcock Medical Center
NOT_YET_RECRUITING

Lebanon, New Hampshire, 03766, United States
HonorHealth
RECRUITING

Scottsdale, Arizona, 85260, United States

Contact Email: •••••@•••••
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21218, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
The University of California, San Diego
NOT_YET_RECRUITING

La Jolla, California, 92093, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of North Carolina Medical Center
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Utah
NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
Vanderbilt University
NOT_YET_RECRUITING

Nashville, Tennessee, 37235, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23284, United States

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