Unity Health Toronto
Clinical trials sponsored by Unity Health Toronto, explained in plain language.
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Can psychotherapy boost Ketamine's pain relief? new pilot study aims to find out
Symptom relief CompletedThis study tested whether adding psychotherapy (a type of talk therapy) to ketamine treatment can help people with long-term nerve pain feel better for longer. Thirty adults with chronic neuropathic pain were split into three groups: ketamine alone, psychotherapy alone, or both t…
Phase: PHASE4 • Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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Laughing gas shows promise for depression in tiny brain scan study
Symptom relief CompletedThis small pilot study tested whether laughing gas (nitrous oxide) can improve mood in people with major depression. 11 participants received either laughing gas or a comparison drug, and had brain scans to look for changes in brain activity. The goal was to see if laughing gas c…
Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 11, 2026 20:41 UTC
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Nerve block may cut opioid use after heart surgery
Symptom relief CompletedThis study tested whether a numbing medicine injected near the chest wall could reduce the need for strong painkillers after heart surgery. 340 adults having open-heart surgery through a breastbone incision took part. Half received the nerve block with a local anesthetic, and the…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 11, 2026 20:38 UTC
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Can rent help and life coaching keep homeless youth housed?
Knowledge-focused CompletedThis study tested whether giving rent subsidies plus a special coaching program helps young people (ages 16-24) who recently left homelessness stay stable. 40 youth in Ontario, Canada, all got rent help; half also got a coach and a guide to build confidence and life skills. The g…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 17, 2026 02:02 UTC
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Brain scans may reveal hidden suicide risk in depressed patients
Knowledge-focused CompletedThis study looked for brain-based signs (biomarkers) that could help predict suicide risk in people with major depression. Researchers used brain scans to measure how participants process pain, reward, and attention. The goal was to find markers that could identify those at highe…
Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Personal navigators boost wellness for care home staff
Knowledge-focused CompletedThis study tested whether giving long-term care and retirement home staff a personal "resource navigator" could improve their overall wellness, reduce burnout, and increase COVID-19 vaccination. 123 staff members took part, with some getting one-on-one support and others not. The…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 13, 2026 15:59 UTC
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Large study aims to predict brain bleeds in rare HHT disease
Knowledge-focused CompletedThis study looked at over 2,200 people with hereditary hemorrhagic telangiectasia (HHT), a rare condition that causes abnormal blood vessels. The goal was to find out what makes some people with HHT more likely to have a brain bleed. Researchers collected health information, bloo…
Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 12, 2026 13:40 UTC
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New program aims to boost confidence for youth leaving homelessness
Knowledge-focused CompletedThis study tested a 4-week in-person leadership program for young people aged 16-24 who have recently left homelessness. The main goal was to see if participants liked the program and found it helpful. Researchers also checked if the program improved feelings of purpose and confi…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 11, 2026 20:40 UTC
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Navigator program aims to keep homeless patients out of the hospital
Knowledge-focused CompletedThis study tested whether a case management program (the Navigator program) helps homeless adults get follow-up care with a primary care provider after being hospitalized. Over 650 homeless adults participated, and researchers tracked their outcomes for 180 days after discharge. …
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 08, 2026 12:01 UTC
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Reaching the unreachable: new approach to collect patient social data tested
Knowledge-focused CompletedThis study tested whether having a community health surveyor reach out to patients makes them more likely to complete a questionnaire about their social needs, like income or housing. About 760 adult patients from a family health team who were considered hard-to-reach took part. …
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 07, 2026 18:39 UTC