Can psychotherapy extend Ketamine's pain relief? small study hopes to find out

NCT ID NCT05639322

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ketamine alone, therapy alone, or both together. The main goal was to see if the combined approach is feasible and safe, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Ketamine hydrochloride (an anesthetic drug) and cognitive behavioral therapy/mindfulness meditation
What this could lead to
If successful, this could point toward a longer-lasting treatment for chronic nerve pain without needing frequent repeat infusions.
What could go wrong
This is a very small pilot study (30 people) focused on feasibility, not proof of effectiveness. Results may not apply to everyone with neuropathic pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NEUROPATHIC PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.