Can psychotherapy extend Ketamine's pain relief? small study hopes to find out
NCT ID NCT05639322
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ketamine alone, therapy alone, or both together. The main goal was to see if the combined approach is feasible and safe, not yet to prove it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ketamine hydrochloride (an anesthetic drug) and cognitive behavioral therapy/mindfulness meditation
- What this could lead to
- If successful, this could point toward a longer-lasting treatment for chronic nerve pain without needing frequent repeat infusions.
- What could go wrong
- This is a very small pilot study (30 people) focused on feasibility, not proof of effectiveness. Results may not apply to everyone with neuropathic pain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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