Can a skin injection of ketamine and lidocaine tame CRPS pain?
NCT ID NCT04650074
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether injecting a mix of ketamine and lidocaine into the skin, a technique called mesotherapy, can reduce neuropathic pain in people with complex regional pain syndrome type 1 (CRPS1). Participants receive four sessions of either the drug mixture or lidocaine alone. The study measures pain levels and other symptoms to see if this approach offers a new way to manage this difficult condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A mixture of ketamine and lidocaine injected into the skin via mesotherapy
- What this could lead to
- If effective, this approach could offer a new, well-tolerated way to manage chronic neuropathic pain in CRPS1, potentially reducing reliance on systemic medications.
- What could go wrong
- This is a small pilot study, and results may not be conclusive or generalizable. The treatment's effectiveness and safety are not yet established, and mesotherapy carries risks like injection-site reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of orthopedic surgery and trauma emergencies of the lower limb, Edouard Herriot Hospital, Hospices Civils de Lyon
Lyon, 69437, France
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