Could a botox shot in the mouth silence stubborn nerve pain?

NCT ID NCT03848143

Completed Symptom relief Sponsor: Isabel Moreno Hay Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This pilot study is testing whether injecting Botox directly into the painful area inside the mouth can reduce continuous nerve pain in the teeth or jaw. Eight adults with long-lasting dentoalveolar pain that hasn't responded to standard treatments will receive two rounds of injections three months apart. They will track their pain daily using a simple 0-to-10 scale to see if the treatment brings relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: onabotulinum toxin A (Botox) injected into the painful area inside the mouth
What this could lead to: If it works, this could offer a new treatment option for people with hard-to-treat nerve pain in the mouth or jaw.
What could go wrong: This is a very small pilot study with only 8 participants, so results may not apply widely. Botox injections can cause temporary weakness or swelling in nearby muscles.

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Conditions

The condition(s) this trial relates to.

neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROPATHIC PAIN

Contacts and locations

Locations

Orofacial Pain Center

Lexington, Kentucky, 40536, United States

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