NEUROPATHIC PAIN

This study tests a small cap placed on cut nerves during finger amputation surgery to prevent painful nerve growths (neuromas) and chronic pain. About 20 adults who recently lost a finger due to injury will receive the Tulavi Allay™ Nerve Cap and be followed for pain levels, cold…

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study aims to translate and test a questionnaire called PainPREDICT in Thai, and build a mobile app to help screen for painful diabetic neuropathy—a common nerve complication in diabetes. Researchers will enroll 277 adults with type 1 or type 2 diabetes to check if the tool …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. About 63 adults with spinal cord injury and chronic neuropathic pain will receive either real rT…

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. The goal is to see if the software is safe, easy to use, and provides some pain relief. Twenty-five adults with HIV and stable pain will use the VR pr…

This study compares three different NSAID painkillers (diclofenac, meloxicam, indomethacin) combined with home exercises for frozen shoulder. 120 adults with shoulder pain and stiffness will be randomly assigned to one of the drugs. The goal is to see which drug works best and wh…

This study tests whether playing a virtual reality walking game can reduce nerve pain in adults with chronic spinal cord injury. Researchers will enroll 250 people who have had a spinal cord injury for at least a year and experience daily pain of at least 4 out of 10. Participant…

This study compares three treatments—mirror therapy, brain stimulation (rTMS), and robotic hand therapy—added to standard rehab for stroke survivors. It aims to see which best improves arm movement, quality of life, and pain. About 120 adults aged 40-80 who had a stroke at least …

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with recent spinal cord injuries will receive either calcitonin or a placebo, and their pain levels will be tracked for up to a year. The g…

This study tests whether a capsaicin 8% skin patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 whose pain started after surgery or injury. About 46 teens will receive either the real patch or a placebo dressing. The main goal is to se…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Researchers will apply high-frequency magnetic pulses to a brain area involved in pain processing. Sixty adults with spinal cord injury and at …

This study tests whether a high-dose capsaicin patch (the stuff that makes chili peppers hot) can relieve chronic tailbone pain. About 188 adults with pain lasting over 3 months will receive either the active patch or a low-dose placebo patch. The main goal is to see if more peop…

This study is testing whether combining a non-invasive brain stimulation technique (rTMS) with virtual reality mirror therapy can better relieve chronic nerve pain that hasn't responded to standard drugs. Researchers will enroll 64 adults with moderate to severe nerve pain lastin…

This study tests whether cannabis compounds (THC, CBD, or both) can reduce chronic nerve pain better than a placebo. It involves 320 Veterans with persistent nerve pain and allodynia (pain from light touch). Participants will take one of four treatments for 6 weeks, and researche…

This study tests a newer way to give epidural steroid injections for people with long-term leg pain caused by nerve problems. It compares the new 'transgrade' method to the standard 'interlaminar' method. The goal is to see which approach provides better pain relief at 3 months. …

This study tests whether playing a virtual reality walking game can help reduce nerve pain in adults with incomplete spinal cord injury. Researchers will measure changes in pain intensity and quality. The study aims to enroll 48 participants who have had persistent pain for at le…

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce long-term nerve pain in the legs and improve daily function. Ten adults aged 18-60 with nerve pain lasting over 6 months will receive both treatments together. The goal is to see i…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat-related chest injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see…

This study tests whether combining body illusions (tricks that change how you perceive your body) with mild brain stimulation can reduce nerve pain and improve sensation in people with spinal cord injury. Researchers will enroll 30 adults with long-lasting neuropathic pain. The g…

This study tests a closed-loop spinal cord stimulator that automatically adjusts stimulation in real time to reduce nerve pain caused by chemotherapy. About 20 adults with persistent pain in their arms or legs will be followed for a year. The goal is to see if this smart device c…

This study tests whether training the leg's reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. The study lasts about 6.5 months and invol…

This study tests whether eye drops made from cord blood plasma can reduce pain and improve nerve health in people with neuropathic corneal pain—a chronic eye pain condition. Twenty adults with persistent eye pain and abnormal corneal nerves will use the drops and report their pai…

This study compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by combat injuries in Ukraine. Fifty adults with moderate to severe pain from neuromas will be randomly assigned to one treatment. The go…

This study compares two treatments for long-lasting nerve pain after shingles (postherpetic neuralgia). Researchers will test an ultrasound-guided nerve block and a radiofrequency treatment to see which provides better pain relief. The study involves 50 adults aged 18 to 80 who s…

This study looks at a surgery called RPNI that may help reduce nerve pain and improve daily life for people who have had a leg amputated. The surgery takes the cut nerve end and wraps it in a small piece of the patient's own muscle to help it heal better. Researchers will follow …

This study tests a new way to stimulate the brain (called Burst-DBS) to see if it reduces chronic pain after a stroke or from nerve damage in the face. About 20 adults with severe, long-lasting pain will try both the new burst method and standard continuous stimulation to compare…

This study tests whether taking two dietary supplements (PEA and Scutellaria) along with a structured exercise program can reduce nerve pain and damage caused by chemotherapy. About 40 adults who have nerve pain after recent chemotherapy will be followed for 60 days. The goal is …

This study tests whether a non-invasive brain stimulation technique called TMS can reduce stubborn nerve pain in people with spinal cord injuries. Researchers will compare two brain areas—the motor cortex and the anterior cingulate cortex—to see which works better. The trial invo…

This study tests a safe, at-home brain stimulation device (tDCS) for people with chronic pain who only got short-term relief from hospital-based treatment. Over 3 months, 70 participants will use either the active device or a sham version for 20 minutes, 5 days a week. The goal i…

This early-stage study tests a new oral drug, EC5026, in 36 adults with spinal cord injury who have nerve pain. The main goal is to check safety and tolerability over 14 days, while also seeing if it reduces pain compared to a placebo. Participants take one pill daily and undergo…

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist group receiving usual care. The goal is to see if ex…

This study tests a non-invasive magnetic brain stimulation technique called deep rTMS for people with long-term nerve pain or fibromyalgia. About 70 adults will receive either real or fake (sham) treatment over 3 months to see if it safely reduces pain. The goal is to find a new …

This study looks at whether adding ultrasound-guided shoulder injections to a home exercise program can improve pain, movement, and daily function in people with chronic frozen shoulder. About 68 adults with shoulder pain lasting at least 3 months will receive either one type of …

This study compares two types of nerve blocks to prevent chronic pain after video-assisted lung surgery. Forty adults scheduled for elective lung surgery will be randomly assigned to receive either an ultrasound-guided nerve block or a surgeon-given block. The goal is to see whic…

This study is testing a new tool called CANoPy that predicts the risk of developing nerve pain in cancer patients before they begin treatment. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer to see if the tool can accurately identify thos…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain. Researchers will measure certain chemicals in the blood and spinal fluid of 30 adults before and after SCS treatment. The goal is to understand how SCS works and find ways to make it mor…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study looks at whether ginger supplements can change gut health and reduce pain in people with chronic sciatica. Eighty adults with leg pain from sciatica will take either ginger or a placebo daily for 8 weeks. Researchers will measure gut bacteria, inflammation, and brain s…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain after back surgery. Researchers will use brain scans to understand why some types of SCS work better than others. The goal is to find out which patients are most likely to benefit, so tre…

This study looks at people with shoulder pain lasting at least 3 months to understand how nerve-related pain and a condition called central sensitization (where the nervous system becomes overly sensitive) are connected. Researchers will use questionnaires to measure pain, nerve …

This study is collecting information from 4500 people who need brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find out what factors help predict how well someone will recover after surgery. By standardizing how outcomes are …

This study looks at 150 adults with muscle, joint, or sports-related pain to see how their PainDETECT questionnaire scores match up with where their pain is and what their doctor diagnosed. Researchers will review existing medical records without any extra tests or treatments. Th…

This study looks at how nerve pain (neuropathic pain) impacts the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain severity and quality of life in 128 adult volunteers using standard questionnaires. The goal is …

This study aims to find out how often nerve pain (neuropathic pain) occurs in people aged 80 and older. Researchers will also see how nerve pain relates to overall health in this age group. About 450 participants will answer pain questionnaires and undergo physical exams. The goa…

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…