VA launches major trial of THC and CBD for Veterans' nerve pain

NCT ID NCT05351801

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether cannabis-based medicines—THC, CBD, or a combination—can safely reduce chronic nerve pain in Veterans. 320 participants will receive one of these treatments or a placebo for six weeks. The goal is to see if these options offer better pain relief than current treatments, which often fall short.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: THC (Syndros), CBD (Epidiolex), and THC+CBD (Nabiximols)
What this could lead to: If successful, this trial could provide evidence that cannabis-based medicines are a safe and effective option for managing chronic neuropathic pain, especially for Veterans.
What could go wrong: This is a mid-stage trial with 320 participants, so results are not definitive. The effects may be modest, and side effects like dizziness or drowsiness are possible. It also focuses on Veterans, so findings may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROPATHIC PAIN PERIPHERAL NEUROPATHIC PAIN

Contacts and locations

Locations

Providence VA Medical Center, Providence, RI
RECRUITING

Providence, Rhode Island, 02908-4734, United States
South Texas Health Care System, San Antonio, TX
RECRUITING

San Antonio, Texas, 78229-4404, United States
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
RECRUITING

West Haven, Connecticut, 06516-2770, United States
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
ACTIVE_NOT_RECRUITING

West Los Angeles, California, 90073-1003, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
TERMINATED

Seattle, Washington, 98108-1532, United States
VA San Diego Healthcare System, San Diego, CA
RECRUITING

San Diego, California, 92161-0002, United States

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