NEUROPATHIC PAIN

This study tested whether the drug brivaracetam can reduce nerve pain in people with chronic spinal cord injury. 44 adults took either the drug or a placebo for 7 weeks. Researchers measured changes in pain intensity and how pain affected daily life, mood, and sleep.

This study tested if a special electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or fake stimulation alongside their usual care. The go…

This study looked at whether a single shot of numbing medicine near the ribs (called a rhomboid intercostal block) can lower the chance of long-term pain after breast cancer surgery. 254 women having mastectomy were split into two groups: one got the block, the other did not. Res…

This early-stage study tested a single dose of a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Half received the drug, half a placebo, and all were monitored for side effects and changes in blood, urine, and vital signs. The …

This study tested if a non-invasive brain stimulation technique called tDCS can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 people, including both healthy volunteers and patients with long-term nerve pain. The goal was to see if targeting a…

This study tested a non-invasive brain stimulation technique called rTMS to see if it could reduce chronic low back pain. Thirty adults with long-lasting pain received the treatment. The goal was to measure changes in pain levels and understand if this approach could be a helpful…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks, with all visits done by video call. The goal was to see if the device could safely reduce pain and improve quality of life.

This study looked at different rehabilitation programs for 90 adults who had back surgery for conditions like spinal stenosis or slipped vertebrae. The goal was to see which rehab approach best reduces nerve pain, helps patients return to daily activities, and improves quality of…

This study tested non-drug methods to reduce nerve pain in the feet and legs of people with HIV. 196 adults with HIV and long-term nerve pain took part. The goal was to see if these approaches could lower pain and improve daily life.

This study looked at whether a targeted drug delivery system (a pump that sends pain medicine directly to the spine) works better than standard pain pills for people with severe cancer pain. Researchers followed 30 adults whose pain was not controlled by strong opioids. They meas…

This study tested a combination of Nucleo CMP and Vitamin B complex against the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults participated to see if the new combo provides better pain control that lasts even after stop…

This study tested a therapy using special prism glasses (prism adaptation therapy) to see if it can reduce pain and improve movement in people with Complex Regional Pain Syndrome (CRPS) type I, a condition that causes severe, long-lasting pain often after an injury. The therapy a…

This study tested whether adding psychotherapy (a type of talk therapy) to ketamine treatment can help people with long-term nerve pain feel better for longer. Thirty adults with chronic neuropathic pain were split into three groups: ketamine alone, psychotherapy alone, or both t…

This small study looked at 7 adults with long-term nerve pain (neuropathic pain) who had already gotten relief from ketamine. Researchers wanted to see if taking memantine or dextromethorphan after ketamine could help maintain or improve pain control. The goal was to find a pract…

This study tested whether certain health and wellness products could help reduce pain in adults. Over 2,000 people took either the product or a placebo, and researchers measured changes in how much pain interfered with daily life. The goal was to see if these products offer real …

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part, and researchers measured changes in pain, tiredness, and sleep quality. The goal was to see if a simple, non-drug …

This study tested two types of non-invasive brain stimulation—iTBS and 10 Hz rTMS—against a fake treatment to see if they could reduce nerve pain in people with spinal cord injury. 26 adults with long-lasting pain despite medication took part. The goal was to measure changes in p…

This study looked at whether a mild, below-sensation level nerve stimulation (called sub-threshold DRG stimulation) can reduce chronic pain better than a sham (device turned off). Twenty adults who already have a nerve stimulator implant and had good pain relief from standard the…

This study tested whether adding dexmedetomidine to standard spinal anesthesia could reduce acute nerve pain after a leg amputation. Thirty adults having elective leg amputation took part. The experimental group received the extra drug, and researchers measured pain and block dur…

This study tested a one-time pain management class for youth ages 10 to 18 with chronic pain. The class taught kids about pain science and simple skills to help manage their pain. Researchers checked if the class was easy to use and liked by participants, and tracked pain levels …

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people living with HIV. 35 participants used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflammation. The goal was to see…

This study tested an online tool designed to help doctors decide which patients with chronic pain might benefit from spinal cord stimulation. Researchers compared the tool's recommendations with the doctors' own judgments in 80 patients. The goal was to see if the tool could impr…

This study looked at 151 people with shingles to find out who might develop long-lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information to see if certain immune cells could predict this pain. The goal was to create a model that hel…

This study looked at how spinal cord stimulation (SCS) affects the way chronic pain patients feel pain. 34 adults with long-term pain who already had SCS devices took part. Researchers tested different SCS settings to measure changes in pain perception, aiming to understand how t…

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation using brain scans and electrical recording…

This study followed over 2,300 adults from urban areas of Chile for one year to learn more about chronic pain and its effects. Researchers looked at how pain relates to depression, anxiety, sleep problems, and work stress. The goal was to better understand the burden of chronic p…

This study tested whether culturally tailored videos could help Black and Hispanic adults with long-term nerve pain better understand and feel more positive about a treatment called nerve stimulation. Researchers also looked at what factors influence interest in joining such stud…

This study looked at vitamin B12 and folic acid levels in 96 people before and after they took antiepileptic drugs for nerve pain. The goal was to see if these medications lower vitamin levels. The study did not test any new treatment—it only reviewed past lab results.

This study aimed to understand if people with neck-related headaches (cervicogenic headache) have more sensitive nervous systems and nerve pain compared to healthy people. Researchers compared 72 adults with these headaches to healthy volunteers. They used questionnaires to measu…