NEUROPATHIC PAIN

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study looked at whether hypnosis or a placebo pill (given honestly, without deception) can reduce chronic nerve pain and improve how the brain handles pain. Seventy-two adults with long-term nerve pain were randomly assigned to hypnosis, open-label placebo, or usual care. Th…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placeb…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ket…

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This completed study tested whether certain dietary supplements can reduce pain and improve daily life. Over 2,000 adults in the U.S. who wanted less pain took either an active supplement or a placebo for 6 weeks. Researchers measured changes in pain interference and types of pai…

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study looked at whether a single injection of numbing medicine between the ribs (rhomboid intercostal block) can lower the chance of chronic pain after mastectomy. 254 women having breast cancer surgery were split into two groups: one got the block, the other did not. Resear…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This completed study compared 72 adults with cervicogenic headache (headache from the neck) to healthy volunteers. Researchers used questionnaires to measure central sensitization (overactive pain signaling) and neuropathic pain (nerve pain). The goal was to see if these pain mec…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation to see if these changes relate to pain rel…

This study looked at whether showing Black and Hispanic adults with long-term nerve pain a short, culturally sensitive video about nerve stimulation techniques could improve their understanding and expectations. Twenty-eight participants watched a video and reviewed educational m…

This study looked at vitamin B12 and folic acid levels in 96 people with nerve pain before and after they started taking antiepileptic drugs. The goal was to see if these medications lower important vitamin levels. No new treatment was tested; the researchers simply reviewed past…