Spinal Add-On may ease phantom pain after amputation

NCT ID NCT07565662

Completed Symptom relief Sponsor: Universidad Juárez Autónoma de Tabasco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placebo, the other got the standard anesthetic plus dexmedetomidine. The main focus was on pain relief and nerve block duration, with a secondary look at neuropathic pain using a screening tool at 48 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine
What this could lead to: If it works, this could offer a simple way to reduce phantom limb pain after amputation.
What could go wrong: This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The pain reduction may be modest or not significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuralgia Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOWER-LIMB AMPUTATION NEUROPATHIC PAIN PHANTOM LIMB PAIN

Contacts and locations

Locations

Hospital Regional de Alta Especialidad Dr. Juan Graham Casasus

Villahermosa, Tabasco, 86126, Mexico

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