Laughing gas shows promise for depression in tiny brain scan study
NCT ID NCT05528718
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small pilot study tested whether laughing gas (nitrous oxide) can improve mood in people with major depressive disorder. Eleven participants received either laughing gas or a sedative (midazolam), and researchers used brain scans to look for changes in brain activity. The goal was to see if laughing gas might help ease depression symptoms and understand how it affects the brain.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MAJOR DEPRESSIVE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
St. Michael's Hospital
Toronto, Ontario, M5B 1M8, Canada