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Why Won't depression go away? scientists scan brains for answers

NCT ID NCT03537794

Recruiting now Knowledge-focused Sponsor: Unity Health Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and healthy volunteers. The goal is to find biological differences that could lead to better treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Unity Health Toronto

    RECRUITING

    Toronto, Ontario, M5B 1M4, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact