Mental disorder

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This phase 3 trial tests whether a new formulation of dexmethylphenidate (CTx-1301) can improve attention and reduce ADHD symptoms in adults for up to 16 hours. Participants take an optimized dose (25, 37.5, or 50 mg) and complete math tests in a simulated classroom. The study co…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with mental health support to reduce stigma, violence, and depression. Researchers will enroll 400 participants to see if the program is feasible and…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This phase 1 trial tests a single injection of TV-44749, an extended-release form of olanzapine, in Chinese adults with stable schizophrenia. The study aims to check safety, tolerability, and how the drug moves through the body. Participants receive one of three doses of the inje…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study tested a long-acting injectable (LAI) form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. Participants received a single injection of one of several LAI formulations, along with oral capsules, to see how the drug behaves in…

This study tested a behavioral program called CAE-AYA to help teens and young adults with bipolar disorder take their medication more consistently. The program included up to five in-person sessions and a follow-up phone call over eight weeks. Researchers measured adherence using…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested the safety and tolerability of aripiprazole (Abilify) in 21 children and adolescents aged 10 to 17 with schizophrenia or mania. Participants took daily doses of 2 to 30 mg for 14 days. The main goals were to see how many could tolerate the highest dose without s…

This study tests an oral capsule called AK0901 (AZSTARYS) in children aged 6 to 12 with attention deficit hyperactivity disorder (ADHD). The trial compares the drug against a placebo to see if it reduces ADHD symptoms like inattention and hyperactivity. Researchers measure sympto…

This study tested the safety of a new drug called KarXT in 173 adults with schizophrenia. Researchers slowly increased the dose to see how well participants tolerated it and whether food affected the drug. The main goal was to track side effects, with secondary measures looking a…

This Phase 3 trial tested an investigational drug called SEP-363856 in 464 people with schizophrenia who were experiencing acute psychosis. Participants received either the drug or a placebo daily for up to 9 weeks. The study measured changes in symptoms like hallucinations and d…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This small study tested whether transcranial magnetic stimulation (TMS) can lower blood pressure and ease PTSD symptoms in women aged 18-44 who have both conditions. Four participants received 30 TMS sessions over 6 weeks. Researchers measured changes in 24-hour blood pressure an…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This Phase 3 study tested whether ecopipam can safely maintain tic control in 216 people with Tourette's disorder, ages 6 and up. Participants first received open-label ecopipam, then those who responded were randomly switched to placebo or continued ecopipam to see if benefits l…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This study tested whether a once-monthly injection of aripiprazole can help people with schizophrenia avoid a relapse of symptoms. Over 900 adults took part, first switching to oral aripiprazole, then receiving either the long-acting shot or another treatment for up to 38 weeks. …

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study tested a long-acting injectable form of risperidone (Risperdal Consta) in 31 people with schizophrenia or schizoaffective disorder who were already receiving home-care treatment. Participants switched from their usual antipsychotic medication to receive a shot every tw…

About half of people with bipolar disorder struggle to take their medication as prescribed, which can lead to severe consequences. This study tested a customized program called Customized Adherence Enhancement (CAE) that includes education, motivational interviewing, and help wit…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study tested an investigational drug called SEP-363856 in 463 people with schizophrenia who were having severe symptoms. Participants received either the drug or a placebo for 6 weeks. The main goal was to see if the drug reduced symptoms like hallucinations and emotional wi…

This study tested a behavioral activation program given as part of a freshman orientation course at the University of Kansas. The program helps students set personal goals and engage in rewarding activities to indirectly reduce alcohol misuse, stress, binge eating, and depression…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tested whether adding memantine, a drug used for Alzheimer's, to targeted cognitive training (brain exercises) could improve thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 participants took either memantine or a placebo while c…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This study tested a virtual reality application to help diagnose Attention Deficit Hyperactivity Disorder (ADHD) in children aged 8 to 12. The goal was to see if a 3D immersive environment could better measure attention and behavior compared to standard tests. Thirty children wit…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study tested whether prazosin, a drug normally used for high blood pressure, could prevent post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event like an accident or assault. Researchers gave the drug to 15 adults who showed signs of acute…

This study tested an online mentoring program for transgender and gender minority youth aged 14-18. The program paired each teen with an adult transgender mentor for seven 90-minute group sessions focused on building social and emotional skills. The goal was to prevent problems l…

This study tested whether mindfulness training can prevent relapse in people with psychosis. 152 participants who were in remission were randomly assigned to either mindfulness training or standard education. Researchers tracked them for 12 months to see who had a relapse.

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tests whether a non-invasive brain stimulation device, used at home, can safely and effectively ease symptoms of major depression in people who have not improved with medication. Participants use the device for 30 minutes a day, five days a week, for four weeks. The tr…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tests whether shining a specific type of near-infrared light on the front of the brain can safely help people with major depressive disorder. The light is thought to boost energy production in brain cells, which may improve mood. Researchers will measure changes in dep…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This trial explores whether a group-based psychomotor therapy—using breathing, relaxation, and body awareness exercises—can be a practical and acceptable way to help young adults (ages 18-35) with anxiety. The study focuses on whether people will join and stick with the program, …

This study tests whether a 6-week mindfulness program (MBSR) can reduce PTSD symptoms and improve quality of life in people who have been in a road traffic accident. About 110 adults aged 18-60 with PTSD will be randomly assigned to either MBSR or standard care. Researchers will …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tested whether giving teens with ADHD and their parents a question list or a short video before a doctor visit helps them talk more openly and get better care. About 126 English-speaking teens aged 11-17 with ADHD took part. The goal was to see if these tools improve s…

This study tests whether writing about imagined future scenarios (worst-case, best-case, or neutral) can reduce social anxiety symptoms. 270 adults with elevated social anxiety will complete three online writing sessions over three weeks. Researchers will measure changes in anxie…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This pilot study in Pakistan tests a culturally adapted psychological therapy (Y-CMAP) for autistic young people aged 14-24 who have a history of self-harm. The therapy is based on cognitive behavioral therapy and includes 8-10 sessions over three months. The study will check if …

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This study tested whether using a stress ball during a routine fetal checkup (non-stress test) helps pregnant women feel less anxious and more comfortable. 70 pregnant women participated. The goal was to see if this simple, drug-free tool can improve the testing experience for mo…

This study tests whether a headset that delivers tiny electrical pulses to nerves behind the ear can reduce anxiety in teens aged 12-17 with Generalized Anxiety Disorder. Sixty participants will use either the active device or a sham (fake) device for 30 minutes a day, 5 days a w…

This study tests a non-invasive brain stimulation technique called tACS in 50 children and teens aged 6-18 with ADHD. The goal is to see if a mild electrical current applied to the scalp can improve attention and executive function. Participants will receive both real and sham st…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study tests whether watching short telenovela-style videos can reduce anxiety and boost confidence in African-American and Hispanic family caregivers of hospice patients. 62 caregivers will either watch the videos during telehealth visits or receive usual hospice care. The g…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This study looks at whether berberine, a natural compound, can improve cognitive problems like memory and attention in people with schizophrenia. One hundred adults aged 18-60 will take either berberine or a placebo pill for 12 weeks, in addition to their regular antipsychotic me…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This study tested whether using a virtual reality headset showing calming scenery for 20-30 minutes could lower anxiety in parents whose children were in the hospital. 485 parents participated, and their anxiety levels were measured and compared to standard care without any tech-…

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This completed study tested whether taking a daily whey protein drink rich in phospholipids for 6 to 12 weeks could improve memory, mood, and overall wellbeing in healthy adults aged 25 to 49. 119 participants were randomly assigned to receive either the active supplement or a pl…

This study tested an experimental drug called CLE-100 (oral esketamine) in 99 adults with major depression that didn't get better after trying at least two standard antidepressants. Participants took CLE-100 or a placebo pill alongside their usual antidepressant for several weeks…

This study tested whether adding group music therapy to standard speech therapy helps autistic children aged 3-5 improve their language and social skills. Forty children were split into two groups: one got music therapy plus usual speech therapy, the other only speech therapy. Af…

This study tested whether special light glasses could improve sleep, concentration, and mood in university students. 39 students with sleep problems wore the glasses for three weeks. The goal was to see if different light intensities made a difference. If successful, light therap…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether squeezing a stress ball or listening to music during coronary angiography (a heart imaging procedure) can lower pain and anxiety. 180 patients were randomly assigned to use a stress ball, listen to music, or receive standard care. Researchers measured an…

This study tested whether watching calming nature videos through virtual reality glasses or doing progressive muscle relaxation exercises could reduce anxiety in high-risk pregnant women during a non-stress test (NST). 126 women were randomly assigned to one of three groups: VR, …

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This study tested whether watching an animated educational video before a nail biopsy could reduce anxiety, improve understanding, and boost satisfaction. Thirty adults scheduled for a nail biopsy were shown the video. Researchers measured their anxiety, health literacy, and sati…

This pilot study tested a new type of brain stimulation, called accelerated intermittent theta burst stimulation (aiTBS), for people with anxiety disorders or PTSD. Fifteen participants received the non-invasive treatment targeting a novel brain area. The study measured changes i…

This study tested whether an intensive, center-based version of Pivotal Response Treatment (PRT) can improve social communication in preschoolers with autism. 75 children aged 2 to 4 years participated. The therapy combined weekly parent training with center-based sessions for a …

This study tested whether online counseling from a nurse, starting 24 hours before a colonoscopy, could help patients feel less pain and anxiety and be more comfortable. Sixty adults were split into two groups: one got standard care, the other got extra nurse support via face-to-…

This study tested an online version of Parent-Child Interaction Therapy for parents of children aged 2-7 with disruptive behaviors. Twenty-one parents received a 10-week online program with video coaching sessions. The goal was to see if this approach is feasible and acceptable, …

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tests whether watching virtual reality videos of mountains, beaches, and waterfalls before coronary angiography can lower anxiety, boost comfort, and improve patient satisfaction. Researchers will compare first-time angiography patients who use VR goggles to those who …

This pilot study tested a digital mental health program called TEPS for teens aged 12-18 with anxiety. Sixty-six participants were recruited from public libraries and randomly assigned to the digital program or usual library services. The study measured how acceptable, usable, an…

This study tested whether metformin, a drug used for diabetes, can improve cognitive problems in people with schizophrenia. 120 participants took either metformin or a placebo for 24 weeks. Researchers measured changes in thinking skills and brain scans to see if metformin helps.

This study looked at whether virtual reality exposure therapy can reduce anxiety in people with a fear of flying. 84 participants who were diagnosed with flight phobia and had a smartphone took part. The researchers measured changes in flight-related anxiety using questionnaires …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study compared two psychological treatments—cognitive behavioral therapy (CBT) and Ericksonian hypnosis—for reducing symptoms of depression and anxiety. 45 adults with symptoms but no formal diagnosis were randomly assigned to CBT, hypnosis, or a no-treatment control group. …

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This study tested a virtual reality program called Impact VR to help youth aged 10-17 with conduct disorder learn to recognize and regulate emotions. The program involved four weekly sessions in a private setting. Researchers measured changes in callous-unemotional traits, conduc…

This study tested a 22-minute online training program for parents of children aged 5-12 with long-term health conditions. The training taught simple skills based on Acceptance and Commitment Therapy (ACT) to help parents support their child's anxiety. Only 17 parents took part, a…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans.…

This small study tested whether a type of brain stimulation called iTBS could help people who have both hoarding disorder and depression. Fourteen adults received 20 sessions over 4 weeks. Researchers measured changes in hoarding and depression symptoms, as well as brain connecti…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study compared an online yoga program with an online behavioral therapy for adults with depression. Over 500 participants were randomly assigned to either yoga or therapy for 12 weeks. Researchers measured depression symptoms and well-being at several points to see which app…

This study tests whether immersive virtual reality (VR) can safely help people with schizophrenia improve their thinking skills, reduce symptoms, and function better in daily life. Forty adults with schizophrenia or schizoaffective disorder will either receive VR-based cognitive …

This study looked at whether holding powerful poses before exposure therapy can increase testosterone levels and make treatment for social anxiety more effective. 73 adults with social anxiety disorder participated. The goal was to see if this simple change could help people feel…

This study tested whether a 7-minute paced breathing exercise (6 breaths per minute) could reduce anxiety and stress in 30 adults before outpatient GI procedures like colonoscopy. Participants used a noninvasive vibratory device in the waiting room. Researchers measured changes i…

This study tested whether D-cycloserine, an antibiotic that helps the brain unlearn fear, can improve cognitive-behavioral therapy (CBT) for social anxiety. 152 adults with social anxiety took either D-cycloserine or a placebo before or after their therapy sessions. Researchers w…

This study tested whether Collaborative Problem Solving (CPS), a behavioral approach that teaches caregivers to address children's underlying thinking skill deficits, can improve executive function and reduce behavioral symptoms in 54 youth receiving home-based mental health care…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study tested if a social robot could help children aged 4-12 with chronic diseases feel less fear and pain during a blood draw. 90 children were split into three groups: one that played with a robot, one that played a digital game, and one that received standard care. The go…

This study tested whether watching telenovela-style educational videos can help family caregivers of hospice patients feel more confident and less anxious. 59 caregivers participated over 8 weeks. The approach used weekly video lessons during regular hospice visits.

This study tested whether giving oral probiotics to adolescents before non-cardiac, non-digestive surgeries could reduce anxiety and depression afterward. 150 teens aged 12-17 were randomly assigned to receive either probiotics or a placebo. Researchers measured anxiety and depre…

This study looked at whether art therapy can reduce anxiety and improve mental strength in people with chronic kidney disease who are on hemodialysis. Eighty adults who had been on dialysis for at least six months took part. The results measured changes in anxiety and psychologic…

This study tested whether low-intensity ultrasound waves aimed at a specific brain area could help reduce negative symptoms of schizophrenia, such as lack of motivation and social withdrawal. 78 adults with stable schizophrenia received either real or fake ultrasound over 20 days…

This study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…

This study looked at whether a web-based program called webSTAIR, which teaches skills to manage emotions and relationships, is feasible and helpful for people with PTSD who are on a waitlist for behavioral health treatment. Seventy adults from a hospital clinic in Boston took pa…

This completed trial tested whether a 4-week mindfulness program delivered via smartphone app could reduce anxiety and stress in college students. 289 students participated, practicing daily mindfulness exercises. The study measured changes in anxiety levels and perceived stress …

This study tested a structured online program for parents of children with autism or ADHD. 90 families took part to see if the program could lower parental stress, improve coping skills, and boost social support. Researchers compared parents who received the program to those who …

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested whether a gentle ear stimulation technique could reduce stress and anxiety in healthcare workers during the COVID-19 pandemic. 62 workers were randomly assigned to receive the stimulation or be placed on a waiting list. The goal was to see if this simple, non-dr…

This study tested a virtual reality app called StoryTelling Medicine (STM) to see if it could reduce anxiety in children aged 8–13 before elective surgery. The app guides kids through hospital settings in a fun, interactive way. Researchers measured anxiety, heart rate, and stres…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether wearing virtual reality glasses during a common kidney stone treatment (ESWL) can lower patients' pain, anxiety, and improve comfort. Seventy adults undergoing the procedure for the first time took part. Researchers measured pain, anxiety, and comfort le…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested a shorter version of Cognitive Processing Therapy (CPT) for Veterans with PTSD. Many Veterans drop out of the standard 12-session therapy, missing the most helpful parts. The goal was to find which therapy components work best and deliver them in fewer sessions …

This study tested whether listening to Baroque music for 30 minutes could reduce anxiety in 18 adults with major depressive disorder. Participants listened to a specially chosen set of Baroque pieces, and their anxiety levels were measured before and after. The idea is that the m…

This study tested two smartphone-based digital treatments alongside standard medication for people with schizophrenia who struggle with low motivation and lack of pleasure. Over 460 adults and teens took part for 16 weeks. The goal was to see if these apps could ease these tough …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This small pilot study tested whether a daily probiotic (Lactobacillus rhamnosus) could reduce abdominal pain and anxiety in children aged 9 to 13. Nine children who had both anxiety and stomach pain took the probiotic for 30 days. Researchers measured changes in pain and anxiety…

This study tested a program based on Acceptance and Commitment Therapy (ACT) for 64 caregivers of people with mental disorders. The program aimed to help caregivers build psychological resilience, manage stress better, and feel less burdened. Results showed that those who took pa…

This study tested a short therapy called Painhunting for adults in Kazakhstan who felt depressed after a stressful life event, like losing a loved one. 84 people were randomly assigned to get the therapy right away or join a waitlist. The therapy involves up to six one-on-one ses…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study looked at whether motivational interviewing, a type of counseling that boosts inner motivation, can help nursing students feel less anxious and more confident about their clinical practice. 66 first-year nursing students took part in a randomized trial. The goal was to…

This study tested whether a treatment called radiofrequency, combined with a special massage, can reduce pain during sex that starts after having a baby. 80 women who had pain 4 to 12 months after giving birth took part. The goal was to see if this approach could lower pain and i…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study tested a program called ASPEN, which coaches parents of young children with autism in low-resource communities. The program includes 12 sessions teaching parents strategies to improve their child's social communication and play skills, while also reducing parenting str…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This study tested a device called Reacor that uses biofeedback to teach mindfulness by showing your heart rate and brain waves in real time. 188 adults with anxiety disorders were split into three groups: biofeedback alone, the medication escitalopram alone, or both together. The…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study looked at whether adding game elements to tai chi can improve thinking skills and reduce challenging behaviors in children with autism. About 100 children aged 9 to 12 took part. They were split into three groups: one did gamified tai chi, one did regular tai chi, and …

This study tests whether a smartphone app can help reduce negative symptoms of schizophrenia, such as lack of motivation and pleasure. It includes 73 adults and older teens who already completed a previous trial with the same app. Participants use the app for 16 weeks alongside t…

This study looked at whether a 10-week supervised physical activity program is practical and well-liked by mothers of children with developmental disabilities. Nineteen mothers were enrolled to attend three 60-minute group exercise sessions per week. The goal was to see if the pr…

This study tested a 4-week music program called 'Tuned In' for 133 Hong Kong teens struggling with low mood, anxiety, or loneliness. Participants were randomly assigned to start the program right away or wait 4 weeks. The program, led by a psychologist and music therapist, aimed …

This study tested a virtual support group called the Sister Circle for Black women aged 40 and older who have depressive symptoms. The program ran for 8 weeks and aimed to see if it was feasible and acceptable. Thirty women participated, and researchers measured how many complete…

This study tested a program called the Westmead Feelings Program 2 for Chinese children with autism in Hong Kong primary schools. The goal was to help them better understand and manage emotions. 85 children took part, and researchers measured changes in emotional skills and behav…

This study tested a smartphone app that uses cognitive behavioral therapy (CBT) to help treat depression. 146 adults with depression used the app for 8 weeks, completing weekly AI-guided lessons and homework. The goal was to see if the app could reduce depression symptoms, as mea…

This study tested an accelerated form of transcranial magnetic stimulation (TMS) in 50 adults with treatment-resistant depression. Participants received 50 sessions over two weeks, comparing a bilateral approach (stimulating both sides of the brain) with a unilateral one (stimula…

This study tested whether a nasal spray containing vasopressin, a natural hormone, can improve social functioning in children with autism. 157 children aged 6 to 17 took part. Researchers measured changes in social responsiveness and overall symptoms over 8 weeks.

This study looked at whether using a virtual reality hypnosis headset during a frozen embryo transfer is practical and can help lower anxiety. Fifty women undergoing IVF used the headset during the procedure. The main goal was to see if the headset could be used without technical…

This study tested three short, one-time digital sessions (called Project YES) designed to help teens and young adults ages 13-25 who have depression, anxiety, or eating disorder symptoms. Participants completed questionnaires before the session, right after, and again 3 months la…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested whether playing virtual reality games (like Nintendo Switch Sports) could improve balance and walking in young people with autism, compared to standard physical therapy exercises. Thirteen participants aged 7-22 did six sessions over two weeks at home via Zoom. …

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested whether cannabigerol (CBG), a compound from hemp, can improve mood, reduce anxiety, and ease stress. 38 adults who had used cannabis before took CBG or a placebo in a double-blind crossover design. Researchers also tracked side effects like sleepiness and dry mo…

This study compared two types of nerve blocks for pain control after breast surgery: the serratus posterior superior intercostal plane block and the PECS II block. One hundred adults aged 21 to 70 were enrolled. Researchers measured how much morphine patients needed in the first …

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study looked at whether having dim light (50-80 lux) in the delivery room can help reduce pain and anxiety during labor. 120 pregnant women in active labor were randomly assigned to either a dimly lit room or standard lighting. Researchers measured pain and anxiety levels at…

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This study tested whether Eye Movement Desensitization and Reprocessing (EMDR) therapy can help adults with post-traumatic stress disorder (PTSD) in Jordan. 70 people with moderate to severe PTSD symptoms were randomly assigned to receive EMDR from a psychiatric nurse or to a wai…

This study tested a personalized brain-training method called neurofeedback for children with ADHD. 51 children participated, and the training was tailored to each child's unique brain patterns. The goal was to see if this approach could improve attention and reduce ADHD symptoms…

This study looked at whether painting mandalas during chemotherapy can help reduce anxiety, nausea, and improve comfort. 73 first-time chemotherapy patients took part. One group colored mandalas for at least 30 minutes during treatment, while the other group received standard car…

This study tested whether transcranial magnetic stimulation (TMS), a noninvasive treatment that uses magnetic fields to stimulate brain regions, can improve PTSD symptoms and related brain activity. Fifty adults with partial PTSD received either active TMS or a sham procedure ove…

This study tested whether internet-delivered cognitive behavior therapy (ICBT) can help teens aged 13-17 with mild to moderate depression. 219 participants were randomly assigned to guided ICBT (with therapist support), self-guided ICBT (without support), or usual care. The goal …

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study tested a program called RESET, led by community health workers, to improve physical and mental well-being in older adults. Over 450 African American adults aged 50+ with symptoms like depression, anxiety, or chronic pain took part. The program included weekly group pho…

This study looked at whether hemp-derived cannabinoids can reduce menopause and perimenopause symptoms like hot flashes, anxiety, and mood swings. 104 women aged 40-60 who were not regular cannabis users took part. Researchers tracked their symptoms daily and monthly to see if th…

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This study tested a virtual peer agent—a friendly AI that talks with teens—to see if it can help them handle stressful life events. Fifty-five teens aged 14 to 25 used the agent for 4 weeks, having conversations about emotions, coping strategies, and support. Researchers checked …

This study looked at two simple ways to help adults feel less pain and anxiety during a blood draw: doing breathing exercises or squeezing a stress ball. 90 people took part, split into three groups: one did breathing exercises, one used a stress ball, and one had no special tech…

This study tested an 8-week program called STAIRS for people recovering from depression. The program combines group meetings with homework exercises to help improve personal recovery and daily functioning. 36 adults in the final phase of depression treatment took part. The goal w…

This study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with recurrent depression. Sixteen people aged 60 and older took part. The goal was to see if this combination improved memor…

This study tested three ways to deliver Acceptance and Commitment Therapy (ACT) for adults aged 20-40 with mild to moderate PTSD in Pakistan. Participants were split into three groups: standard clinic therapy, clinic therapy with a supporting web app, and fully online therapy wit…

This study tested whether a 10-week virtual reality program could help people with schizophrenia stop smoking. 160 participants were split into a VR group or a no-treatment group. Researchers measured nicotine dependence, smoking behavior, and quality of life before and after the…

This study tested whether adding levetiracetam (a seizure medication) to standard antipsychotics helps people with early psychosis who still have symptoms. 65 participants took either the drug or a placebo for 12 weeks. The goal was to see if it reduces psychotic symptoms and pro…

This pilot study tested a 6-session therapy called Goal-Focused Emotion Regulation Therapy (GET) in 35 young Latino testicular cancer survivors aged 18-39. The therapy helps participants set goals, manage emotions, and find meaning after cancer. Researchers measured anxiety, depr…

This study tested whether squeezing a stress ball during an ultrasound-guided biopsy can reduce pain and anxiety. 79 adults were randomly assigned to either use a stress ball or receive standard care alone. Researchers measured pain, anxiety levels, and vital signs before and aft…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS could help cancer survivors who smoke feel less distressed and smoke fewer cigarettes. 43 participants used the device at home via telehealth. The main goal was to see if people found the dev…

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This study tested whether a short, daily Loving-Kindness Meditation (LKM) could help reduce symptoms of depression and anxiety and improve relationships. 240 women college students were randomly assigned to listen to a 5-minute LKM or a visualization meditation each day for one w…

This study tested a brief, community-based psychological program called Problem Management Plus to see if it can reduce depression, anxiety, and distress. Over 1,200 adults with mild to moderate symptoms took part. The program focuses on practical problem-solving skills in just f…

This study tested whether an AI chatbot called Emohaa can reduce symptoms of depression, anxiety, and loneliness in young adults aged 15 to 30. 222 participants with emotional distress were randomly assigned to use the chatbot, receive traditional counseling, or join a waitlist. …

This study tested whether a combination of two brain stimulation techniques—repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS)—could improve cognitive function in people with bipolar disorder who are in remission. 116 parti…

This study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…

This study looked at whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could improve cognitive function in 42 adults with stable schizophrenia. Participants either received risperidone alone or risperidone plus 10 weekly CBT sessions. Research…

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This study tested a new way to use repetitive transcranial magnetic stimulation (rTMS) to treat depressive episodes in 40 adolescents with bipolar disorder. Instead of the usual front-brain target, researchers stimulated the visual cortex at the back of the brain, aiming to affec…

This study tested two ways to help adults with anxiety and depression become more aware of their emotions and learn to rethink them. One group used a smartwatch to track emotions in real time, while the other reflected on their day each evening. Over six weeks, both groups showed…

This study looked at whether pairing first-year nursing students with older student mentors can lower their stress. Starting nursing school can be tough, and the program offered guidance on time management, studying, and coping. 120 students took part, with some getting a mentor …

This study tested a brief, two-session therapy program for young adults (ages 18-35) who had recently started early psychosis services. The program, adapted from a US-based intervention called 'Just Do You,' aimed to improve treatment engagement and recovery by addressing barrier…

This study tested a non-invasive brain stimulation technique called temporal interference stimulation (TI) to improve depression in people with bipolar disorder. Thirty-six participants received 10 sessions over two weeks, targeting a deep brain area linked to pleasure and reward…

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This completed study tested whether an ultrasound-guided nerve block (TAP block) provides better pain relief after C-section than standard pain medicine. 100 women aged 20-50 who had a C-section took part. Researchers measured pain scores to see which method worked better.

This small study tested whether adding whole-body hyperthermia (like a sauna session) to cognitive behavioral therapy (CBT) is feasible for adults with major depression. Sixteen participants received up to 8 weekly or 4 bi-weekly sauna sessions along with 8 weekly CBT sessions. T…

This study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…

This study tested whether a short digital task could help NHS staff who kept having unwanted, intrusive memories of traumatic events from working during the COVID-19 pandemic. About 122 healthcare workers took part, using either a memory-competing computer game, a music-listening…

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive function in 82 people with stable bipolar disorder. Participants received task-activated rTMS while doing cognitive training. Th…

This study tested whether adding whole-body hyperthermia (mild heat sessions) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly therapy. The main goal was to see …

This study tested whether an 8-day creativity camp could help 160 teens aged 12-17 with depression symptoms think more flexibly and feel more positive. The camp included various creative arts activities. Researchers measured changes in depression and anxiety scores using question…

This study tested a computer-assisted cognitive behavioral therapy program called Raising Our Spirits Together (ROST) for rural adults with depressive symptoms. The program was delivered in small groups by local pastors, either online or in person at churches. Researchers compare…

This study tested a program called MOSAIC Plus for pregnant women and mothers of children under 5 who have experienced intimate partner violence and have symptoms of depression or PTSD. The program pairs women with community advocates who provide support and teach skills to impro…

This study tested whether taking buprenorphine (a low-dose opioid) after a ketamine infusion can reduce suicidal thoughts more quickly and effectively than ketamine alone in people with major depression. Fifty adults participated, and researchers measured changes in suicidal idea…

This study looked at whether different intensities of exercise can reduce anxiety in adults with anxiety disorders. 110 sedentary adults with high anxiety sensitivity were assigned to either low-intensity exercise or a program that gradually increased to high-intensity exercise o…

This Phase 3 trial tested whether adding troriluzole to standard OCD medications could reduce symptoms better than a placebo. The study enrolled 589 adults with OCD who had not responded well enough to their current treatment. After 8 weeks, troriluzole did not lead to significan…

This study tested whether aromatherapy with essential oils can reduce anxiety in adults before elective upper limb surgery. 289 participants were randomly assigned to either receive aromatherapy or not. The goal was to see if the scent helped people feel calmer in the operating r…

This study tested whether a humanoid robot named HUMANE could help older adults living at home feel less lonely and more connected. Sixty people aged 50 and older used the robot for 6 weeks, interacting with it through music, news, games, and conversation. Researchers measured lo…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This study tested a drug called ecopipam in 40 children aged 7 to 17 with Tourette's syndrome. The goal was to see if it could reduce the frequency and severity of their motor and vocal tics. The drug works by blocking certain dopamine receptors in the brain. The main measure was…

This study tested a psycho-educational program designed to help family caregivers of children with autism become more aware of their own needs and better at seeking support. Fifty caregivers of children aged 6 to 12 took part. The program involved teaching coping strategies and w…

This study tested two simple, drug-free methods — squeezing a stress ball or practicing the 4-7-8 breathing technique — to help elderly patients feel less fearful and anxious before an upper GI endoscopy. 75 first-time patients were randomly assigned to one of the techniques, and…

This small pilot study tested whether a single 25mg dose of psilocybin, given with psychological support, could help people with treatment-resistant depression who still struggle with anhedonia—the inability to feel pleasure or interest. Twenty adults took either the full dose or…

This study tested whether a new oral medicine, BI 1569912, can help adults aged 18 to 65 with major depressive disorder. 225 participants were randomly assigned to one of three doses of the drug or a placebo, taken daily for 6 weeks. Researchers measured changes in depression sym…

This pilot study tested whether adding cognitive behavioral therapy (CBT) to usual care helps reduce irritability and suicidal thoughts in children aged 8 to 12 with anger and aggression issues. 46 children were assigned to either CBT plus usual care or usual care alone. The ther…

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

This study looked at whether bright light therapy helps depression equally well in spring/summer compared to autumn/winter. Over 200 adults with depression received daily 30-minute light sessions for at least a week. Researchers measured symptom changes and followed up for three …

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study compared two well-known talk therapies for depression: cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both were delivered in online group sessions over 8 weeks. A total of 116 adults with major depressive disorder took part. The goal wa…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve core symptoms in 200 children with autism spectrum disorder. Children received either real or sham stimulation over five days, with multiple…

This study tested whether a single dose of BNC210 can quickly reduce anxiety in people with social anxiety disorder. 370 adults took either the drug or a placebo before a public speaking challenge and rated their distress. The goal is to see if BNC210 works as an as-needed treatm…

This study looked at whether multi-family therapy (therapy with several families together) can help teenagers who refuse to go to school because of anxiety. 74 teens aged 12-18 who had been out of school for at least 2 weeks took part. The researchers measured anxiety and school …

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce auditory hallucinations in people with psychotic disorders. Twenty-four participants received the stimulation while researchers measured changes in hallucination severity and brain activit…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This Phase 2 trial tested a new drug called EB-1020 SR (centanafadine) in 45 adult men with ADHD. The goal was to see if it could reduce symptoms like inattention and hyperactivity. Participants took the drug or a placebo for a few weeks, and researchers measured changes using a …

This study tested an online psychological service called eClinic for young adults aged 15 to 35 in Hong Kong who have moderate to severe anxiety or depression. The eClinic offers a private, flexible online platform with therapist-guided self-learning modules. Researchers measured…

This study compared two types of nerve blocks (serratus posterior superior intercostal plane block and deep serratus anterior plane block) to see which provides better pain relief after breast surgery. Sixty-two adults having a mastectomy received one of the two blocks with bupiv…

This study tested an experimental drug called ML-004 in 168 adolescents and adults with autism spectrum disorder to see if it could improve social communication skills. Participants were randomly assigned to receive either the drug or a placebo for several weeks. The main goal wa…

This early-phase study tested whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy is a feasible and acceptable treatment for major depression. Sixteen adults with moderate to severe depression received two doses of psilocybin …

This study tested a 6-week program called BUILT for families with children aged 6 to 12 who have ADHD. The program teaches healthy habits around sleep, nutrition, and exercise to help improve focus and behavior. Researchers measured changes in physical activity, sleep, diet, and …

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in patients undergoing a procedure called ERCP. Seventy adults were randomly assigned to either learn the breathing technique or receive standard care. The techni…

This study tested whether teaching children aged 9-12 how to manage their time during haemodialysis can reduce their anxiety and fear. Twenty children were split into two groups: one received the training, the other got usual care. Researchers measured anxiety and fear levels bef…

This study tested whether a smartphone app could help people with PTSD quit smoking and avoid starting again. Participants received counseling, stop-smoking medications, and rewards for not smoking, plus the app. The goal was to see if the app made it easier to stay smoke-free co…

This study tested two relaxation methods—laughter yoga and emotional freedom technique (EFT, a type of tapping)—to see if they could lower anxiety in pregnant women. 120 pregnant women with high anxiety scores took part. The goal was to find simple, drug-free ways to help moms-to…

This study tested whether using a virtual reality clinic (Doxy.me VR) is as good as standard online therapy for treating intense fear of dogs, snakes, or spiders. Fifty-four adults participated, and researchers measured how much their phobia symptoms improved. The goal was to see…

This study tested whether a virtual reality (VR) social skills program works as well as an in-person group program for preschool children with autism. Thirty-two children aged 4 to 6 were randomly assigned to either VR or in-person sessions over 8 weeks. Researchers measured soci…

This study tested whether adding a virtual reality (VR) module that helps children imagine future events could improve standard brain-training exercises for kids with ADHD. Eighty children aged 5 to 12 took part, with half doing only the standard training and half also using VR h…

This study tested whether wearing virtual reality goggles during dental sealant placement helps children ages 6-18 feel less anxious and behave better. Each child served as their own control, receiving VR on one side of the mouth and standard care on the other. The researchers me…

This study tested whether using a stress ball and listening to relaxing music during a colonoscopy can reduce pain and anxiety. 100 adults undergoing the procedure without sedation were split into two groups: one used the stress ball and music, the other received standard care. T…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will analyze medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their mood…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study looked at how schizophrenia affects physical activity, balance, muscle strength, and thinking skills. Researchers measured these abilities in 35 adults diagnosed with schizophrenia. The goal was to better understand the challenges patients face, which could help improv…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This trial compares two high-intensity training programs—CrossFit and running-based HIIT—in elite male distance runners who live and train at moderate altitude. Over six weeks, participants train five days per week and undergo tests for aerobic fitness, strength, and blood marker…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This study looked at two specific proteins in the blood of people with bipolar disorder during a manic episode and compared them to healthy volunteers. The goal was to see if these proteins, which are linked to inflammation and brain cell communication, could help explain the con…

This study looked at levels of a specific enzyme, α-N-acetylgalactosaminidase, in the blood of people with panic disorder who had never taken medication. Researchers compared these levels to healthy individuals and checked for connections with symptom severity and inflammation. T…

This study examines whether levels of a blood enzyme called α-N-acetylgalactosaminidase differ between people with schizoaffective disorder during acute episodes and those in remission, compared to healthy individuals. The goal is to better understand the biological processes beh…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This completed study looked at how the brain processes reward signals to improve mood in people with depression. Researchers used brain scans, a mild magnetic stimulation technique (TMS), and a single injection of buprenorphine (a painkiller) to see how these affect brain activit…

This study looks at whether children with ADHD are more likely to have very flexible joints (benign joint hypermobility) and if a certain blood marker differs. Researchers will compare 171 children aged 6 to 12—some with ADHD and some without—using physical exams and blood tests.…

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This completed study looked for genetic changes linked to autism spectrum disorder in over 1,600 participants. Researchers focused on genes involved in brain cell communication, hoping to understand which biological pathways are involved. The goal was to gather knowledge that cou…

This study tested a two-day training program designed to help newly graduated nurses speak up about patient safety concerns. 76 nurses from a hospital in Ankara, Turkey, were split into two groups: one received the training, the other did not. Researchers measured changes in comm…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study developed and tested a new questionnaire called the Excessive Emotional Behaviors Scale (EEBS) for Chinese adults experiencing anxiety or depression. Researchers interviewed 18 people and surveyed 637 participants to refine the scale, which measures behaviors like avoi…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This study looked at whether brain activity patterns can predict how well people with major depression or social anxiety respond to cognitive behavioral therapy (CBT). Over 200 participants were randomly assigned to 12 weeks of CBT or supportive therapy. Researchers measured brai…

This study tested a 10-week emotional intelligence program for first-year college students aged 18-25. The program aimed to improve how students identify, understand, use, and manage emotions. Researchers measured changes in emotional attention, clarity, and regulation, as well a…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study tested whether a role model-based ethics course could reduce moral injury and stress in 101 second-year medical students in Taiwan. Students chose between a standard version with stories and handouts, or an enhanced version with extra writing and guest speakers. Resear…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at 6 children with past PTSD to see if changes in attention and memory could predict a relapse. Researchers used computer tasks and standard tests to measure brain function. The goal is to find early warning signs so families can get help sooner.

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

This study compared two types of orthodontic appliances—removable braces and clear aligners—in 24 children aged 6 to 12 with crossbite. Researchers measured changes in speech, oral hygiene, pain, anxiety, and quality of life over two weeks. The goal was to understand how each app…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study surveys anesthesiologists to explore whether feelings of being a fraud (impostor phenomenon) are linked to everyday memory and attention lapses. Participants complete online questionnaires about impostor feelings, cognitive failures, anxiety, depression, sleep quality,…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study tested whether using augmented reality (AR) or a 3D hip model helps first-year nursing students learn how to give intramuscular injections better than traditional methods. 146 students were randomly assigned to practice with AR, a 3D model, or a standard model. Researc…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study looked at 15 people with depression who experienced temporary dissociative states (feeling disconnected from reality) while taking Esketamine. Researchers used interviews to understand these experiences better. The goal is to learn more about this side effect to improv…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study looked at what makes it hard for new moms with postpartum depression to get mental health care, especially online. Researchers interviewed 10 women and then tested a virtual patient navigation program with 26 moms over 2 months. The goal was to see if the program was e…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This completed study looked at how adults with autism spectrum disorder (ASD) process emotions in moral situations, compared to people without autism. Researchers used stories about harm and accidents, then asked participants to quickly identify faces or judge if facial expressio…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looked at how people with schizophrenia process sounds and remember where information comes from. Researchers tested 50 participants (patients and healthy controls) using computer tasks. The goal was to understand if trouble telling sounds apart relates to difficulty d…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study tested whether oxytocin nasal spray helps people with social anxiety disorder learn safety from watching others. About 120 adults received either oxytocin or a placebo and underwent brain scans. The goal was to see if oxytocin improves the brain's ability to tell threa…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study surveyed 186 adults with sickle cell disease in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, and healthcare use. Participants completed online questionnaires about their medical history, mental health, and experiences during the pan…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether listening to upbeat music can change how people with depression perceive emotions in faces and voices. Researchers compared the effects of positive and neutral music in 39 adults with and without depression. The goal was to see if positive music could…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study compared two types of radiation for people with 11 to 20 brain tumors that spread from other cancers. One group got Gamma Knife radiosurgery, which targets each tumor precisely. The other got whole brain radiation, which treats the entire brain. The goal was to see whi…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

This study looked at two ways to assess ADHD in children aged 8-17: a brief protocol (medical history, interview, rating scales) and a comprehensive one that also includes neuropsychological testing. Researchers wanted to see if the shorter method is as reliable, valid, and cost-…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study tested whether a 6-session online class called HEARTS helps autistic adults feel more satisfied with their friendships and dating relationships, compared to a 6-week online discussion group. Ninety-two autistic adults took part over three months, completing surveys abo…

This study tested a family navigator program and a smartphone app to help low-resourced families of young children (ages 3-5) with autism find and access services. 52 families took part. The program aimed to improve parents' knowledge, skills, and confidence in getting support fo…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at whether an adaptive e-learning course on urgent medical conditions could reduce anxiety and improve skills in junior doctors starting work in emergency departments. 233 new doctors were randomly assigned to either take the course in their first six weeks or r…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study tested a coaching program for doctors to improve communication with Black and Latinx families during hospital rounds. The program taught doctors to be more respectful, collaborative, and trauma-aware. Researchers measured whether families felt more trust and satisfacti…

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study tested a digital suicide prevention program for teens in pediatric primary care. Thirty at-risk youth aged 12-17 and their parents used the tool, which helps doctors identify and address suicidal thoughts and behaviors. The goal was to see if the program is practical a…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study gave 100 healthy adults either 50 mg of CBG or a placebo to see how it affects anxiety, stress, mood, memory, and physical signs like heart rate and blood pressure. Researchers also tracked side effects like sleepiness or dry mouth. The goal is to better understand bot…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This completed study tested an oral form of the painkiller nalbuphine, called PHN131, in 16 healthy adults. The goal was to see how the body absorbs and processes the pill compared to the injected version. Researchers also monitored safety by checking vital signs like blood press…

This study followed nearly 10,000 Stanford undergraduates over their college years to understand how social ties, loneliness, and stress relate to anxiety and depression. Researchers used surveys and social network analysis to track changes in mental health. The goal is to create…

This study looked at whether a therapy called FAST (Forensic Outpatient Systemic Therapy) helps teens aged 12-21 with conduct disorder or aggressive behavior. The therapy involves weekly sessions with the teen and their caregivers for several months. Researchers measured changes …

This study tested a program called Multi-Family Healing Spaces for families affected by the Rwandan genocide. 319 family members aged 12 and older from five districts took part. The program aimed to improve family communication, resilience, and mental health. Results will show if…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study looked at how low doses of LSD change the way healthy adults make decisions based on what they see. Thirty participants completed computer tasks that tested their ability to predict and respond to visual patterns. The goal was to understand how LSD influences brain sig…

This study looked at whether signals from the heart and brain during transcranial magnetic stimulation (TMS) can predict which people with major depression will get better. Thirty-two adults received an accelerated TMS treatment over 5-8 days while their heart rate was monitored …

This study looked at how children with autism (without intellectual disability) form and recall paired memories, like linking a face to a name. Researchers used EEG brain scans and memory tests to compare 74 right-handed children aged 10-18, half with autism and half without. The…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a 4-session education program for people with early schizophrenia. The goal was to see if it helps patients feel more connected to their therapist, which is important for ongoing care. 21 hospitalized patients took part, and researchers measured changes in the p…

This completed Phase 1 trial tested whether the experimental drug SP-624 affects brain electrical activity in 26 people — some healthy, some with major depression. Participants took SP-624 or a placebo daily for two weeks. Researchers used EEG and AI to look for changes in brain …

This study looked at how the brain and heart respond to stressful images and sounds in women who have had multiple pregnancy losses and also have anxiety. Researchers used special head sensors and heart monitors to measure these reactions in 70 women. The goal was to find pattern…

This study tested whether a single 15-minute session of Butterfly Tapping, a self-administered EMDR technique, could change brain activity in 46 young adults with PTSD. Participants either did the tapping or sat still while their brain waves were recorded. The tapping group showe…

This study looked at how the brain uses 'noise'—random variations in brain cell activity—to help people learn. Researchers tested 47 healthy adults using brain scans and computer models to see if this noise makes learning faster or more efficient. The goal was to understand a bas…

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study looked at how people with schizophrenia perceive familiarity when looking at faces. Researchers showed 30 participants blended images of familiar and unfamiliar faces and asked them to press a button when they felt a sense of familiarity. The goal was to understand how…

This study tested a program called Naungan Kasih-Hybrid that combines a single in-person session, teacher-led WhatsApp groups, and a chatbot to help parents of preschoolers in low-income families in Malaysia. Over 770 parents and 750 children from 50 preschools took part. The goa…

This study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…

This study tested an 8-week parenting program called Circle of Security-Parenting for mothers with depression and infants showing signs of social withdrawal. Researchers compared it to standard care to see if it improves how mothers interact with their babies and helps the child'…

This completed Stanford study looked at whether video-recorded facial expressions and speech patterns can reflect a person's mood. Eleven adults with depression or epilepsy had electrodes temporarily placed in their brains to record brain activity. Researchers stimulated certain …

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study tested a smartphone app called A4i designed to help people with schizophrenia manage their illness and stay connected with their care providers. 91 adults with schizophrenia or related disorders used the app for 6 months. The goal was to see if the app was practical an…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study looked at whether a virtual reality (VR) education program could help first-time radiation therapy patients understand their treatment better and reduce anxiety and depression. 84 cancer patients were split into two groups: one received VR education, the other standard…

This study tested a Portuguese version of the DIVA questionnaire to see if it reliably measures how vaginal aging symptoms (like dryness, itching, or pain) affect daily activities, sex life, emotions, and body image. 300 women with at least one symptom of vulvovaginal atrophy too…

This study compared how 59 children with and without autism look at videos of people interacting. Researchers measured where children focused their eyes—on faces, objects, or the background—to understand differences in social attention. The goal was to learn more about how autism…

This study looked at 202 Polish adults with chronic low back pain to find out how severe their anxiety symptoms are. Participants filled out a questionnaire called GAD-7, which scores anxiety from none to severe. The goal was simply to measure the problem, not to test any treatme…

This study used eye-tracking to see how emotional expressions (low, medium, or high intensity) influence how children with autism understand intentions. Researchers watched where 80 children looked during a puzzle task. The goal was to learn more about attention patterns, not to …

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This completed study used eye-tracking technology to understand how children with autism spectrum disorder (ASD), intellectual disability (ID), and typically developing children process visual cues. Researchers showed 80 children videos of a model choosing objects and recorded th…

This study compared virtual reality (VR) training to standard classroom teaching for nursing students learning how to triage in a mass casualty incident. 100 nursing students took part. The goal was to see if VR helps them triage more accurately and quickly.

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study tested whether offering tai chi classes online is a practical way to help veterans with PTSD and chronic pain. Researchers worked with 42 veterans to see if they would attend sessions and find the program satisfactory. The goal was to gather information needed to desig…

This study looked at how often older adults feel anxious or depressed after breaking a bone from a fall and having surgery. Researchers used a simple questionnaire to check symptoms in 40 patients aged 65 and older, both those who had surgery and those who did not. The goal was t…

This study looked at 56 adults with fully remitted depression who wanted to stop their antidepressant. Researchers wanted to see how much of the withdrawal symptoms are caused by the drug itself versus the person's expectations. Participants were randomly assigned to either stop …

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…