Mental disorder

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This trial tests an experimental medicine called BI 1569912 in adults aged 18 to 65 with major depressive disorder whose current antidepressants aren't working well enough. Participants take a single dose of the drug or a placebo, in addition to their usual antidepressant, and ar…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This trial tests whether different intensities of breathing exercises (inspiratory muscle training) can improve diaphragm function, thinking, sleep, and mood in young adults aged 18-25 who have low muscle mass. Participants will be randomly assigned to high-intensity, moderate-in…

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This trial tests whether levetiracetam, a drug used for seizures, can reduce overactivity in the hippocampus—a brain area linked to memory—and improve cognitive function in people with schizophrenia or schizoaffective disorder. Participants receive either levetiracetam or a place…

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether adding Gottman couple therapy to usual depression treatment helps women with major depressive disorder who are in distressed relationships. The therapy focuses on improving communication and emotional connection between partners. Researchers will compare …

This study tests whether an AI-based decision support tool can help therapists deliver internet-based cognitive behavioural therapy (iCBT) for depression, panic disorder, and social anxiety. About 400 adults with these conditions will receive 12 weeks of iCBT, with therapists usi…

This trial tests whether a non-invasive technique called transcranial electrical stimulation (tES) can help reduce ADHD symptoms and improve thinking skills in children and teenagers aged 7 to 18. The approach uses low-intensity electrical currents applied to the scalp to gently …

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether aripiprazole, a medication already used for behavioral symptoms, remains safe and tolerable for children and adolescents with autistic disorder when taken daily for up to a year. Most participants will have already completed a short-term trial of the drug…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…

This trial tests whether a daily supplement called WeNatal For Him can improve markers of male fertility, including sperm quality, testosterone levels, energy, and libido. Forty men aged 30 and older who report low energy and low libido will take three capsules each morning for t…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial tests whether an experimental drug called KH607 can reduce symptoms of postpartum depression in adult women. Participants take the drug or a placebo once daily for two weeks. The study measures changes in depression scores to see if KH607 offers a safe and effective sh…

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in adults hospitalized with bipolar I disorder who are currently experiencing a manic or mixed episode. Participants will receive either lumateperone or a placebo daily for s…

This study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…

This study looks at whether taking two approved medicines together—escitalopram for depression and atorvastatin for high cholesterol—can improve both mood and blood fat levels in adults. Participants are adults diagnosed with both a depressive episode and mild-to-moderate dyslipi…

This study tests whether a type of talk therapy called cognitive behavioral therapy (CBT) can help teenagers with panic disorder. The therapy includes 11 weekly sessions designed to change how teens think about and react to panic symptoms. Participants track their anxiety daily. …

This study tests whether an intensive, 8-day form of cognitive behavioral therapy (CBT) can help adolescents with panic disorder and agoraphobia. The therapy includes 15-20 hours of one-on-one sessions focused on changing anxious thoughts and gradually facing feared situations. S…

This study explores whether eating fewer ultra-processed foods (like packaged snacks and fast food) can help lift mood in people with moderate-to-severe depression. Participants either receive meal kits with minimally processed foods or get nutritional guidance only. The study al…

This study compares two treatments for depression in children aged 7 to 13: a family-focused therapy that works with both the child and parents, versus individual therapy for the child alone. The family approach aims to improve parent-child interactions, communication, and coping…

This study tests a personalized cognitive remediation program for people with schizophrenia or schizoaffective disorder. Participants work on computer-based cognitive exercises and take part in group discussions to improve thinking skills like memory and attention. The goal is to…

This trial tests whether a 12-week exercise program can improve motor skills, aerobic capacity, and quality of life in children aged 5–13 with autism spectrum disorder. Participants do activities like walking, balancing, and ball games. Researchers compare them to a non-exercisin…

This study tests a new virtual reality (VR) software that delivers behavioral activation therapy for people with depression. Behavioral activation helps people re-engage in positive activities to improve mood. Participants use hand-tracking to interact with the VR environment, co…

This study tests whether a noninvasive brain stimulation technique called iTBS-TMS can reduce suicide risk in adults with major depression or borderline personality disorder who are experiencing suicidal thoughts. Participants receive either real or sham (placebo) stimulation to …

This study tests whether a new drug called AVP-786 can help people with major depressive disorder who have not gotten enough relief from standard antidepressants. Participants take AVP-786 or a placebo alongside their current antidepressant for 10 weeks. The main goal is to see i…

This study looks at switching from risperidone to aripiprazole (Abilify) in people with schizophrenia who are not getting enough symptom relief or are having side effects from risperidone. Participants are randomly assigned to one of two ways to switch medications over 12 weeks. …

Autistic children drown at 160 times the rate of their peers, yet standard swim lessons often fail them. This study tests a new approach that adapts instruction based on a child's sensory profile—whether they seek, avoid, or have mixed reactions to sensory input. Researchers will…

This phase 3 trial investigates whether adding aripiprazole (Abilify) to an antidepressant improves symptoms in adults with major depressive disorder who have not responded adequately to antidepressants alone. Participants take either aripiprazole or a placebo alongside their usu…

This study tests whether a group-based behavioral program, where caregivers are actively involved, can help autistic preschoolers improve social communication, play skills, and daily adaptation. The program is compared to one-on-one therapy. Researchers will measure changes in au…

This study tests whether a behavior therapy program called Partnering to Achieve School Success (PASS) can improve outcomes for children aged 5-11 with ADHD from low-income families. Children are randomly assigned to receive PASS integrated into their primary care visits or to re…

This trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…

This trial compares a generic form of cariprazine (a drug used for schizophrenia) to the brand-name version Reagila®. Healthy adults aged 18 to 55 receive a single dose of either the generic or brand drug under fasting conditions. The main goal is to see if the generic version is…

This study tests whether regular video or phone calls with a nurse (tele-nursing) can help teenagers with type 1 diabetes improve their blood sugar control, feel more confident managing their condition, and reduce anxiety. Participants aged 12–18 receive diabetes education both i…

This study tests a computer-based practice method to help people with aphasia—a language disorder often caused by stroke—retrieve words they know but struggle to say or understand. Participants practice naming pictures with or without cues, repeating items until they reach a set …

This study tests whether deep brain stimulation (DBS) — a device that sends electrical pulses to specific brain areas — can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive a DBS implant targeting two …

This study tests whether structured physical games can improve memory, attention, gross motor skills, and social adaptability in children aged 4 to 6. Over 8 weeks, preschoolers play specially designed games like 'Eagle Catching Chicks' and 'Puppy Seeking Bones' during class. Res…

This phase 3 trial tests whether a new formulation of dexmethylphenidate (CTx-1301) can improve attention and reduce ADHD symptoms in adults for up to 16 hours. Participants take an optimized dose (25, 37.5, or 50 mg) and complete math tests in a simulated classroom. The study co…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This phase 1 trial tests a single injection of TV-44749, an extended-release form of olanzapine, in Chinese adults with stable schizophrenia. The study aims to check safety, tolerability, and how the drug moves through the body. Participants receive one of three doses of the inje…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested the safety and tolerability of aripiprazole (Abilify) in 21 children and adolescents aged 10 to 17 with schizophrenia or mania. Participants took daily doses of 2 to 30 mg for 14 days. The main goals were to see how many could tolerate the highest dose without s…

This study tests an oral capsule called AK0901 (AZSTARYS) in children aged 6 to 12 with attention deficit hyperactivity disorder (ADHD). The trial compares the drug against a placebo to see if it reduces ADHD symptoms like inattention and hyperactivity. Researchers measure sympto…

This study tested the safety of a new drug called KarXT in 173 adults with schizophrenia. Researchers slowly increased the dose to see how well participants tolerated it and whether food affected the drug. The main goal was to track side effects, with secondary measures looking a…

This Phase 3 trial tested an investigational drug called SEP-363856 in 464 people with schizophrenia who were experiencing acute psychosis. Participants received either the drug or a placebo daily for up to 9 weeks. The study measured changes in symptoms like hallucinations and d…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression. Adults aged 22 and older will record their voice, and the device's assessment will be compared to a standard clinical interview. The goal is to see if the device can acc…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression in adults. About 1,600 English-speaking adults aged 22 and older will record their voices, and the device's screening results will be compared with a standard clinical in…

This study tests a telemedicine tool called the TAP, designed to assess autism symptoms in toddlers aged 18-42 months. Researchers will compare diagnoses made via video call with traditional in-person evaluations to see how accurate the tool is. The goal is to make autism diagnos…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. 27 children aged 14-72 months watched pictures and videos while the device measured their eye movements. The goal was to see if these eye-tracking patterns match a clinic…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This trial tests whether a one-day online workshop based on cognitive behavioural therapy (CBT) can reduce the risk of postpartum depression and anxiety. Pregnant women in their third trimester who have a history of depression but are not currently depressed will be randomly assi…

This trial tests whether short, equipment-free exercise sessions in the classroom can ease anxiety, depression, and stress while boosting physical activity in medical students. Around 105 students will be split into groups receiving either two, one, or no exercise sessions per we…

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests whether a parenting program can help expectant couples learn to co-parent as a team and reduce heavy drinking in fathers. 368 couples are enrolled during pregnancy and followed for a year after birth. The program includes group classes and individual sessions foc…

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study tests whether low-cost virtual reality (VR) tools, like 360° video and a new VR Photoscan process, can help people with post-traumatic stress disorder (PTSD) engage more easily with trauma-focused therapy. Participants will receive standard therapy (TF-CBT) either alon…

This trial tests whether an online psychiatric nursing program based on the Tidal Model can improve psychological resilience and self-compassion in adults diagnosed with anxiety disorder. Participants are randomly assigned to either receive eight one-on-one online nursing session…

This trial tests three different approaches to help people with bipolar disorder become more physically active. Participants are randomly assigned to receive brief advice alone, or brief advice plus supervised and home-based exercise with either health education or cognitive-beha…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested a daily dietary supplement (DITTO Cycle Supplement) in 40 women aged 18-45 who regularly experience period symptoms like cramps, bloating, fatigue, and mood swings. Over three menstrual cycles, researchers tracked changes in symptom severity and quality of life …

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study looks at whether adding sensory and cognitive activities—like listening to music, gentle touch, or brain exercises—to standard ICU care can help adults recover faster after heart surgery. About 125 patients will be randomly assigned to one of four groups to see which a…

This study tests whether a 15mg dose of the painkiller ketorolac works as well as a 30mg dose for relieving kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over several hours.…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This study explores whether sleep problems in children with ADHD are linked to being overly sensitive to everyday sensations, like touch or sound. It tests a bedtime routine called 'Power Down' that uses gentle massage and calming cues to help children relax before sleep. The stu…

This six-week study tests whether two liquid supplements, BrainJuice Peach Mango and BrainJuice ACTIVE Pomegranate Acai, can improve cognitive function, performance, and mood in healthy adults aged 18-57 who have concerns in these areas. Participants drink one supplement daily fo…

This study tests an 8-week hybrid physiotherapy program for adults aged 45-75 who live with both chronic pain and depression. The program combines weekly face-to-face sessions on pain science with guided exercises and online videos. Researchers will measure changes in pain intens…

This study tests a program called I2-ART, where trained family navigators support caregivers of minority children with ADHD. The goal is to help families follow through with recommended treatments like medication or behavior therapy. The study involves about 108 participants and …

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests a 12-week supervised exercise program for adults with severe mental illness, such as schizophrenia, bipolar disorder, or major depression. The program combines cycling, strength training, and breathing exercises in twice-weekly sessions. Researchers will measure …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study tests whether adding a sensor-based exergame to regular table tennis practice can help adolescent boys with mild autism react faster and move more quickly during play. Half of the 24 participants will do 20 minutes of light-based reaction training twice a week for 8 we…

This study tested whether a natural compound called palmitoylethanolamide (PEA) can help reduce depression in people with bipolar disorder. 34 adults who were already taking a mood stabilizer took PEA or a placebo. Researchers measured changes in depression scores and looked at h…

This study tests an 8-week online group program that teaches parents of young autistic children (ages 2-6) strategies to support their child's social communication and development. Parents attend weekly sessions and practice techniques at home. Researchers will measure changes in…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This phase 2a trial tests CYB004, a synthetic version of the psychedelic DMT, combined with talk therapy in 36 adults with moderate-to-severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms compared to an active …

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests a new psychoeducation program that teaches military veterans with PTSD how sensory processing affects their stress, emotions, and daily life. Participants learn strategies to better regulate overwhelming situations, improve sleep, and engage socially. The study a…

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This trial tests whether watching a 30-40 minute augmented-reality animation that shows a child's journey through surgery can reduce anxiety in children aged 3-12 before adenotonsillectomy. Half the children will watch the animation before surgery, while the other half receives s…

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This study tested whether adding a long-acting stimulant (methylphenidate) to regular antipsychotic medication can improve thinking and daily function in people with schizophrenia or schizoaffective disorder. Thirty-five adults who were stable on their current treatment took the …

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tested whether a specialized swim program (Sensory Enhanced Aquatics) helps autistic children aged 5-9 learn swimming and water safety better than standard lessons. Fifty-one children participated in 16 half-hour lessons. Researchers measured swimming skills before and…

This trial tests whether a daily synbiotic supplement, combining probiotics and a prebiotic fiber, can ease common perimenopause and menopause symptoms like poor sleep, anxiety, and brain fog. Women aged 44–55 experiencing these symptoms will take either the active supplement or …

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This trial tests whether playing with a rainbow parachute can improve upper arm strength and social-emotional skills in children aged 5 to 8 with developmental delays. Half the children will do parachute games for 8 weeks, while the other half does rhyming activities. Researchers…

This study tested whether repeated doses of ketamine, an FDA-approved anesthetic, could speed up the effects of talk therapy (Prolonged Exposure) for PTSD in 75 veterans. Participants received either ketamine or a placebo alongside therapy. The goal was to see if ketamine could r…

This study tests an online psychological support program based on Acceptance and Commitment Therapy (ACT) for mothers of children with autism. The program aims to reduce parenting stress and improve mothers' mental health, which may also benefit their children's behavior. Mothers…

This trial tests a 12-week guided self-help program for parents of young children (ages 2-6) with neurodevelopmental disorders like autism or ADHD. The program combines a workbook, online modules, and group sessions to teach acceptance and mindfulness skills. The goal is to see i…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This trial tests whether a dissolvable film placed under the tongue, containing the drug dexmedetomidine (BXCL501), can reduce agitation in people with schizophrenia. Participants are adults aged 18 to 65 who are clinically agitated. The study compares different doses of the film…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

This trial tests whether low-frequency whole body vibration—standing on a gently vibrating platform—can improve motor skills and sensory integration in children aged 5 to 9 with mild to moderate autism. Participants receive vibration sessions alongside routine physical therapy, a…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tests whether haptotherapy, a gentle touch-based therapy, can reduce anxiety and improve bonding in pregnant women who have had a previous abortion. Eighty women between 28 and 32 weeks of pregnancy will receive five 45-minute group sessions. Researchers will measure a…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This trial tests whether an 8-week mindfulness-based stress reduction program can help first-time pregnant women feel less depressed, improve their psychological well-being, and strengthen their attachment to their unborn baby. About 108 women in their first pregnancy, between 13…

This study explores whether listening to music after a cesarean section can help first-time mothers feel less pain and anxiety, and improve their breastfeeding success. Participants will be divided into groups, with one group listening to music and the other receiving standard ca…

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study tests whether a precise type of radiation, called stereotactic radiotherapy, can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18 to 50 who have not improved after at least two antidepressant trials will receive the treatment. R…

This trial asks whether wearing a virtual reality (VR) headset before and during short hand surgeries can help reduce pain and anxiety. Adults undergoing elective hand surgery with local anesthesia and sedation will use the VR headset as a distraction. Researchers will measure se…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This study tested an investigational medication called BXCL501 (dexmedetomidine) given as a film under the tongue for episodes of agitation in people with schizophrenia, schizoaffective disorder, or bipolar disorder. The trial included 452 adults aged 18-75 and compared the drug …

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

This study tests a smartphone app called Orbi, which uses cognitive behavioural therapy (CBT) to help people with long-term physical conditions cope with depression and anxiety. 60 participants will either use the app plus usual charity support, or charity support alone, then swi…

This study tested a short, skills-based anxiety treatment for veterans in primary care. 177 veterans with anxiety symptoms were randomly assigned to either the new treatment or usual care. The goal was to see if the brief therapy reduces anxiety and improves daily functioning bet…

This study tests a mobile app-based training designed to help people with social anxiety disorder interpret ambiguous social situations in a more positive, less threatening way. Adults aged 18-60 with moderate to severe social anxiety will use the app over several sessions, and r…

This study looks at whether coloring mandalas can lower stress, anxiety, and pain in women who have a missed abortion (a pregnancy loss before 10 weeks). About 126 women will be randomly assigned to either color mandalas or receive standard care. Researchers will measure changes …

This study looked at whether a web-based program called webSTAIR, which teaches skills to manage emotions and relationships, is feasible and helpful for people with PTSD who are on a waitlist for behavioral health treatment. Seventy adults from a hospital clinic in Boston took pa…

This study compares online parent coaching to in-person coaching for improving social communication in toddlers with autism or social communication delays. About 188 children aged 18-33 months will take part. Parents learn techniques to engage their child during play, aiming to i…

This study tests whether using virtual reality glasses or doing breathing exercises during chemotherapy can help reduce anxiety in breast cancer patients. Participants will be divided into three groups: one using VR glasses, one doing guided breathing exercises, and one receiving…

This study looks at whether adding active video game training to standard occupational therapy can improve how children with developmental coordination disorder (DCD) see and plan movements. About 70 children aged 5 to 8 will be split into two groups: one gets video games plus th…

This trial tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can reduce auditory hallucinations in people with schizophrenia who haven't found relief from antipsychotic medications. Participants receive either real tDCS or a…

This study tests whether combining two types of exercises—sensory motor training and special stretches—can reduce toe walking and improve foot posture in children with mild autism. Researchers will measure changes in foot position and sensory responses in 36 children. The goal is…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This trial is testing a web-based app called Active Ease, designed to help people with severe mental illness living in residential care become more physically active. The app includes educational content and guided exercise demonstrations. Researchers will compare two residential…

This trial tests whether a structured CBT-based program can strengthen psychological resilience and improve quality of life in adults with bipolar disorder who are in remission. Participants will attend sessions focused on psychoeducation, self-management, and coping strategies. …

This study tested whether listening to nada yoga music or squeezing a stress ball can lower anxiety and pain during a Pap smear. 128 women aged 30-56 took part. Researchers measured their anxiety and pain levels before, during, and after the test. The goal was to find simple, dru…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This trial tests whether daily omega-3 fish oil supplements can improve sleep, mood, and behavior in children who have sleep problems and symptoms of ADHD, autism, or both. The study takes a symptom-focused approach, aiming to identify which specific difficulties—like emotional u…

This study tests whether a short, personalized music listening session with a therapist can lower anxiety, stress, and pain in cancer patients starting radiation therapy. 72 adults will be randomly assigned to receive music therapy during their first radiation session or standard…

This study tested whether wearing virtual reality goggles showing relaxing nature scenes with music could help patients feel less anxious and more comfortable during a prostate biopsy. Seventy adults undergoing the procedure were randomly assigned to either wear the goggles or re…

This trial aims to find the optimal dose of bupivacaine, a local anesthetic, for starting epidural pain relief during labor. It will enroll 100 healthy women with a single, full-term pregnancy who request an epidural for pain. The goal is to determine the dose that provides effec…

This study follows 140 people with obstructive defecation syndrome (ODS) — a condition that causes straining and difficulty passing stool — who are scheduled for surgery. Researchers will measure depression and anxiety using standard questionnaires before and after the procedure,…

This trial compares two types of nerve blocks for pain relief after open gastric cancer surgery. The blocks are injected near the abdominal wall to numb the area, potentially reducing the need for opioid painkillers, which can cause side effects like drowsiness and constipation. …

This trial tests whether a mindfulness-based neurofeedback program can help racial and ethnic minority college students reduce performance anxiety and improve academic performance. Participants practice mindfulness meditation while a device monitors their brain activity and provi…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This study tests whether wearing virtual reality glasses during a cystoscopy—a procedure to look inside the bladder—can reduce pain and anxiety. Half of the participants will use VR while the other half receives standard care. The trial aims to see if VR can make the experience m…

This study tests whether wearing virtual reality goggles that show calming nature scenes with music can reduce pain, anxiety, and changes in heart rate and blood pressure during urodynamics, a procedure that checks how well the bladder works. Half of the participants will wear th…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This trial tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce psychological and existential distress in people with advanced, terminal illness. Participants receive rTMS sessions while on a palliative care unit, and researchers measure changes in depress…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This trial tests whether adding a ChatGPT-powered educational tool to standard instructions helps first-time colonoscopy patients achieve better bowel cleansing and feel less anxious before the procedure. Adults undergoing their first colonoscopy are randomly assigned to receive …

This study tests whether a four-week mindfulness program can reduce symptoms of depression, anxiety, and stress in college students in Guangzhou, China. Participants are randomly assigned to either the mindfulness training or a health education control group. The study also looks…

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This trial tests whether Acceptance and Commitment Therapy (ACT), a type of talking therapy that focuses on psychological flexibility, can reduce depressive symptoms in people with bipolar disorder. Participants will attend 12 weekly group sessions of ACT alongside their usual me…

This trial tests whether watching an entertaining video through virtual reality glasses or on a tablet can reduce pain, anxiety, and fear in children aged 7 to 12 during intravenous (IV) cannulation in an emergency department. Children are randomly assigned to one of three groups…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This trial tests whether an intensive version of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), delivered during a hospital stay, helps children and teens aged 11–17 with PTSD after sexual abuse. Researchers compare the inpatient program to standard outpatient therapy to s…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This trial tests whether an eight-session cognitive-behavioral psychoeducation program can reduce internalized stigma in adults with bipolar disorder who are in remission. Participants are randomly assigned to the program or usual care, and their stigma levels are measured before…

This phase 2 trial is evaluating whether an experimental drug called KH607 can safely reduce symptoms of depression in adults with moderate or severe major depressive disorder. The study has two parts: first, all participants receive KH607 openly to check safety and how the drug …

This trial tests whether distraction techniques—like drawing, reading a story, watching a cartoon, or using a toy nebulizer and mask—can lower fear and anxiety in children aged 3 to 6 during inhalation therapy for respiratory infections. Children are randomly assigned to one of t…

This pilot trial tests whether a brief group therapy called EMDR-IGTP-OTS can reduce posttraumatic stress symptoms in migrants attending an adult education center in Italy. Participants receive four structured group sessions on consecutive days and are compared with a control gro…

This trial tests whether a structured, therapist-led dance program can improve cognitive-motor skills, balance, self-esteem, and sensory processing in children aged 6 to 12 with ADHD. Over five weeks, participants attend ten dance sessions designed to combine rhythm and movement …

This trial tests whether a 4-week progressive muscle relaxation (PMR) program can reduce psychological stress and improve bowling speed and accuracy in male cricket medium-fast bowlers aged 18-25. Participants are assigned to either PMR sessions before warm-ups or standard traini…

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial investigates whether a 20-minute virtual reality nature scene or the Benson Relaxation Technique can lower anxiety and increase happiness in adults who have recently had bariatric surgery. Participants are randomly assigned to one of two groups or a control group, and …

This trial investigates whether daily exposure to a bluish-white light (at least 300-500 lux for two hours) can improve sleep efficiency, reduce depression, and calm agitation in people with mild to moderate Alzheimer's or related dementias. Participants are assigned to one of th…

This study is testing a prescription digital therapeutic app, OTX-601, designed to deliver evidence-based PTSD treatment through a smartphone. Researchers are comparing two versions of the app—one with a higher 'dose'—against standard care (therapy and/or medication) in 40 adults…

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in people hospitalized with bipolar I disorder. Participants will receive either lumateperone or a placebo daily for several weeks, and researchers will measure changes in ma…

This study tests whether a six-session video-based cognitive behavioural family intervention is practical and helpful for people with schizophrenia and their family caregivers. The program aims to reduce expressed emotion (critical or hostile communication) and improve symptoms a…

This early-stage trial is testing an experimental drug called lumateperone in children aged 5 to 12 who have autism spectrum disorder and symptoms of irritability. The study aims to see how the body processes the drug and whether it is safe and tolerable at different doses. It is…

This trial tests whether a simple breathing exercise routine can help people recovering from general surgery feel less pain, anxiety, and nausea. About 149 adults who had laparoscopic gallbladder or hernia repair will either receive standard care or practice deep breathing exerci…

This study tests two online programs for people with mild to moderate anxiety or depression who are not already in therapy. One program focuses on five daily behaviors linked to better mood, while the other uses a forgiveness process to address relationship issues. Participants c…

This trial compares two diets—low-FODMAP and lactose- and gluten-free—in adults with irritable bowel syndrome (IBS). Each participant tries both diets for four weeks, with a one-week break in between, to see which one better reduces gut symptoms and improves mental health. The go…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This pilot trial explores whether Nintendo Switch exergaming—active video games like RingFit Adventure and Switch Sports—can improve motor skills in autistic youth aged 5 to 30. Participants are randomly assigned to an exergaming group or a no-intervention control group. The stud…

This trial tests whether an ultrasound-guided nerve block called the mid-transverse process to pleura (MTP) block can improve pain control in children aged 5 to 15 undergoing open chest surgery. Half of the 50 participants will receive the block with bupivacaine before the incisi…

This study tests whether giving family members of ICU patients a QR code that links to an educational video can improve their understanding of the ICU and reduce their anxiety. Participants are randomly assigned to receive either standard verbal information or the same informatio…

This study tests whether two dietary supplements—eicosapentaenoic acid (EPA), an omega-3 fatty acid, and specialized pro-resolving lipid mediators (SPMs)—can reduce depressive symptoms in adults with long COVID. Participants take either EPA, SPMs, or a placebo daily for 12 weeks.…

This trial tests a school-based counselling program called Knowledge Insight Tools (KIT), which is based on cognitive behavioural therapy (CBT). It is designed for secondary school students aged 11-18 who are struggling with anxiety and low mood. Participants first go through a w…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tests a mobile app designed to help people with social anxiety shift their attention away from threatening faces and toward neutral ones. Adults aged 18-60 with social anxiety disorder will use the app for three weeks. Researchers will measure changes in anxiety sympto…

This study tests whether playing a recording of a mother's heartbeat, breathing, and chest vibrations to her newborn during phototherapy for jaundice can reduce maternal anxiety and stress. Forty mothers and their full-term newborns will take part, with half receiving the heartbe…

This trial tests whether a gentle electrical stimulation of the vagus nerve through the ear (tVNS) can help athletes recover more quickly after intense training. About 121 professional athletes in sports like swimming, athletics, and gymnastics will use the device daily for 60 mi…

This trial compares a new painkiller called oliceridine to the standard drug sufentanil for women undergoing hysteroscopy, a procedure to look inside the uterus. The goal is to see if oliceridine provides effective pain control with fewer side effects like nausea or breathing pro…

This study tests whether a computer-based program called cognitive control training (CCT) can help people with depression feel less negative mood and rumination. Participants with high depression scores complete three sessions of CCT or a comparison task over two weeks. The goal …

This study investigates how avoidance behaviors contribute to depression and anxiety in teenagers, and tests a group therapy called Group Behavioral Activation Therapy (GBAT). The therapy involves 15 weekly sessions teaching skills to understand and change avoidance patterns. Res…

This study tests whether combining a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with a type of talk therapy called acceptance and commitment therapy (ACT) can help veterans who have both chronic pain and depression. The goa…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This study tests whether watching an animated educational video before laparoscopic tubal ligation reduces anxiety and pain more than standard verbal counseling. Eighty women are split into two groups: one receives routine verbal information, the other watches a video. Researcher…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study tests a personalized cognitive training program called CBM-TAF for adults with obsessive-compulsive (OC) symptoms. The program targets a specific thinking pattern known as thought-action fusion (TAF), where people believe having an unwanted thought is as bad as acting …

This study investigates whether listening to music before, during, and after intrauterine device (IUD) insertion can lower pain and anxiety while improving satisfaction. Researchers will compare women who receive music therapy to those who do not, measuring anxiety levels with a …

This trial investigates whether a supplement made from Nepalese pepper (Zanthoxylum armatum) can improve cognitive abilities like attention, memory, and decision-making in young competitive gamers aged 16 to 34. Participants take either a low or high dose of the extract, caffeine…

This study investigates whether taking lion's mane mushroom or a blend of lion's mane and reishi mushroom for 28 days can improve wellbeing in women aged 18-26 who feel stressed or anxious. Participants are randomly assigned to receive one of the mushroom supplements or a placebo…

This study tests whether wearing virtual reality glasses and watching a calming nature video during hemodialysis can help lower anxiety and keep vital signs stable. Researchers are enrolling 56 adults who are receiving dialysis for the first time. Half will watch a 4K nature vide…

This study tests whether using a stress ball or watching a short aquarium video with music can reduce fear, anxiety, and pain in children aged 6 to 12 who need an enema for constipation or bloating in the emergency department. Children are randomly assigned to one of the two dist…

This study tests whether adding game-like features to a 12-week mindfulness program can help first-year nursing students reduce burnout, stress, and anxiety. Participants are randomly assigned to a gamified mindfulness group, a standard mindfulness group, or a minimal-treatment c…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This study investigates whether the Benson Relaxation Technique, a simple mind-body practice, can lower fear of childbirth, anxiety, and stress in pregnant women. About 60 women in their third trimester (weeks 28–38) will either practice the technique or receive routine care. Res…

This pilot study tests whether a single session of repetitive transcranial magnetic stimulation (rTMS) can improve the brain activity behind working memory — the ability to hold information in mind. The trial includes teenagers with ADHD and working memory deficits, as well as he…

This study tests whether a short session of age-appropriate play and a structured briefing for parents can lower anxiety in children aged 2 to 11 who are about to have an MRI under sedation. Half of the children receive this psychological preparation before the scan, while the ot…

This trial investigates whether listening to classical music, with or without binaural beats, can lower anxiety and pain in men undergoing a prostate biopsy. Participants are randomly assigned to hear Samuel Barber's Adagio for Strings, the same piece embedded with a 6-Hz binaura…

This study investigates whether performing progressive muscle relaxation exercises before an endometrial biopsy can help reduce pain, lower anxiety, and improve comfort in premenopausal women. Participants will be women aged 40 or older with irregular cycles who need this biopsy.…

This study tests whether a new medication, toludesvenlafaxine, can safely reduce anxiety symptoms in adults with generalized anxiety disorder. Participants receive either a low dose, a high dose, or a placebo pill daily for 8 weeks. The main goal is to see if the drug lowers anxi…

This pilot study tests whether a brief psychological program called Problem Management Plus (PM+) can help reduce anxiety and depression symptoms in people held in Dutch remand prisons. The program, developed by the World Health Organization, teaches problem-solving, stress manag…

This study tests whether a 10-week storytelling (narrative therapy) program can reduce anxiety and depression in middle school students living in refugee camps in northern Palestine. About 120 students aged 12-15 with moderate-to-severe symptoms took part. The program uses cultur…

This study tests whether a computerized eye-tracking training program can improve mood and thinking skills in older adults who have memory complaints but no dementia. Participants aged 60 to 80 will do 18 sessions over about 1.5 months, focusing on tasks that require attention an…

This pilot study tests a 10-session group program called AgingUP, designed for adults aged 50 and older living with severe mental illness. The program uses cognitive-behavioral and self-compassion techniques to help participants challenge negative beliefs about aging and mental i…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This trial tests whether a device called Cognilum, which shines light on the head (transcranial photobiomodulation), can reduce autism symptoms in children aged 2 to 6 with moderate to severe autism. Children wear the device for up to 15 minutes twice a week for 8 weeks. Research…

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This study tests whether a combination of gabapentin, ketorolac, and a nerve block, along with scheduled Tylenol, can reduce the need for opioid painkillers after head and neck cancer surgery involving free flap reconstruction. Half of the 30 participants will receive the standar…

This trial tests whether a device called Cognilum, which shines light on the head (transcranial photobiomodulation), can reduce autism symptoms in children aged 2 to 7 with moderate to severe autism. Children wear the device for up to 15 minutes twice a week for 10 weeks. Researc…

This study tests whether a one-day Acceptance and Commitment Therapy (ACT) workshop can improve psychological flexibility and well-being in university students who have moderate to severe anxiety or depression. Participants are randomly assigned to either attend the workshop or j…

This study tests a gamified mobile app designed to reduce symptoms of depression and rumination (repetitive negative thinking). People with moderate or greater depression use the app for four weeks, completing daily surveys and weekly assessments. The app uses attention bias modi…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce menstrual pain, depression, and anxiety in young women with primary dysmenorrhea (painful periods without an underlying condition). Participants receive either real or sham stimula…

This study tests whether shining a specific type of near-infrared light on the front of the brain can safely help people with major depressive disorder. The light is thought to boost energy production in brain cells, which may improve mood. Researchers will measure changes in dep…

This study tests whether a non-invasive brain stimulation device, used at home, can safely and effectively ease symptoms of major depression in people who have not improved with medication. Participants use the device for 30 minutes a day, five days a week, for four weeks. The tr…

This trial explores whether a group-based psychomotor therapy—using breathing, relaxation, and body awareness exercises—can be a practical and acceptable way to help young adults (ages 18-35) with anxiety. The study focuses on whether people will join and stick with the program, …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This completed study tested whether taking a daily whey protein drink rich in phospholipids for 6 to 12 weeks could improve memory, mood, and overall wellbeing in healthy adults aged 25 to 49. 119 participants were randomly assigned to receive either the active supplement or a pl…

This study tested whether adding group music therapy to standard speech therapy helps autistic children aged 3-5 improve their language and social skills. Forty children were split into two groups: one got music therapy plus usual speech therapy, the other only speech therapy. Af…

This study tested whether special light glasses could improve sleep, concentration, and mood in university students. 39 students with sleep problems wore the glasses for three weeks. The goal was to see if different light intensities made a difference. If successful, light therap…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether squeezing a stress ball or listening to music during coronary angiography (a heart imaging procedure) can lower pain and anxiety. 180 patients were randomly assigned to use a stress ball, listen to music, or receive standard care. Researchers measured an…

This study tested whether watching calming nature videos through virtual reality glasses or doing progressive muscle relaxation exercises could reduce anxiety in high-risk pregnant women during a non-stress test (NST). 126 women were randomly assigned to one of three groups: VR, …

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This pilot study tested a new type of brain stimulation, called accelerated intermittent theta burst stimulation (aiTBS), for people with anxiety disorders or PTSD. Fifteen participants received the non-invasive treatment targeting a novel brain area. The study measured changes i…

This study tested whether online counseling from a nurse, starting 24 hours before a colonoscopy, could help patients feel less pain and anxiety and be more comfortable. Sixty adults were split into two groups: one got standard care, the other got extra nurse support via face-to-…

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This study tests whether watching virtual reality videos of mountains, beaches, and waterfalls before coronary angiography can lower anxiety, boost comfort, and improve patient satisfaction. Researchers will compare first-time angiography patients who use VR goggles to those who …

This pilot study tested a digital mental health program called TEPS for teens aged 12-18 with anxiety. Sixty-six participants were recruited from public libraries and randomly assigned to the digital program or usual library services. The study measured how acceptable, usable, an…

This study looked at whether virtual reality exposure therapy can reduce anxiety in people with a fear of flying. 84 participants who were diagnosed with flight phobia and had a smartphone took part. The researchers measured changes in flight-related anxiety using questionnaires …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study compared two psychological treatments—cognitive behavioral therapy (CBT) and Ericksonian hypnosis—for reducing symptoms of depression and anxiety. 45 adults with symptoms but no formal diagnosis were randomly assigned to CBT, hypnosis, or a no-treatment control group. …

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This study tested a virtual reality program called Impact VR to help youth aged 10-17 with conduct disorder learn to recognize and regulate emotions. The program involved four weekly sessions in a private setting. Researchers measured changes in callous-unemotional traits, conduc…

This study tested a 22-minute online training program for parents of children aged 5-12 with long-term health conditions. The training taught simple skills based on Acceptance and Commitment Therapy (ACT) to help parents support their child's anxiety. Only 17 parents took part, a…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tested whether a 7-minute paced breathing exercise (6 breaths per minute) could reduce anxiety and stress in 30 adults before outpatient GI procedures like colonoscopy. Participants used a noninvasive vibratory device in the waiting room. Researchers measured changes i…

This study tested whether D-cycloserine, an antibiotic that helps the brain unlearn fear, can improve cognitive-behavioral therapy (CBT) for social anxiety. 152 adults with social anxiety took either D-cycloserine or a placebo before or after their therapy sessions. Researchers w…

This study tested whether Collaborative Problem Solving (CPS), a behavioral approach that teaches caregivers to address children's underlying thinking skill deficits, can improve executive function and reduce behavioral symptoms in 54 youth receiving home-based mental health care…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This completed trial tested whether a 4-week mindfulness program delivered via smartphone app could reduce anxiety and stress in college students. 289 students participated, practicing daily mindfulness exercises. The study measured changes in anxiety levels and perceived stress …

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This small pilot study tested whether a daily probiotic (Lactobacillus rhamnosus) could reduce abdominal pain and anxiety in children aged 9 to 13. Nine children who had both anxiety and stomach pain took the probiotic for 30 days. Researchers measured changes in pain and anxiety…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study tested three short, one-time digital sessions (called Project YES) designed to help teens and young adults ages 13-25 who have depression, anxiety, or eating disorder symptoms. Participants completed questionnaires before the session, right after, and again 3 months la…

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study looked at two simple ways to help adults feel less pain and anxiety during a blood draw: doing breathing exercises or squeezing a stress ball. 90 people took part, split into three groups: one did breathing exercises, one used a stress ball, and one had no special tech…

This study tested whether an 8-day creativity camp could help 160 teens aged 12-17 with depression symptoms think more flexibly and feel more positive. The camp included various creative arts activities. Researchers measured changes in depression and anxiety scores using question…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This study looks at whether ethnic minority adolescents who have experienced racial discrimination show stronger biological stress responses when faced with subtle racism. Researchers will measure blood pressure, stress hormones, and other markers while teens take part in a simul…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This pilot trial is testing whether a program called CRUSH, designed to teach sexual health and relationship skills, is practical and well-received by autistic adults aged 18 to 30. Participants will attend 15-20 group sessions with one-on-one coaching and complete assessments be…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study tests whether a mild electrical brain stimulation technique called transcranial direct current stimulation (tDCS) can alter brain activity in adults with major depression. Using MRI to guide the stimulation, researchers will measure changes in brain connectivity and al…

This study looks at whether spending 2 to 3.5 weeks at a device-free summer camp in Maine can improve mental health and brain activity in teens aged 12 to 17. Researchers will measure changes in mental health scores and brain waves (EEG) from the start to the end of camp. The goa…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study asks whether a scenario-based simulation, where nursing students interact with an actor portraying a person with schizophrenia, can boost their knowledge, empathy, and caregiving skills. Around 105 students will complete questionnaires before and after the simulation, …

This study tests whether a fast form of brain stimulation (accelerated iTBS) can improve thinking and memory in 30 adults with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. Participants will receive both real stimulation and a sham (fa…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This study looks at whether post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists is linked to higher rates of complications in the patients they operate on. Researchers will screen surgical staff for PTSD using questionnaires and then track the recovery of thei…

This study tests whether breathing exercises and aerobic exercise can change levels of certain brain and inflammation markers in people with major depression. Forty adults diagnosed with depression will do daily breathing and aerobic exercises for three weeks. Researchers will me…

This study looks at how the gut microbiome and its chemical byproducts relate to gastrointestinal and behavioral symptoms in children with autism. By tracking 23 participants over time, researchers hope to identify biological markers that could one day help manage these symptoms.…

This study looks at pain, sleep quality, eating habits, and physical activity in 50 adults with bipolar disorder who are currently stable (euthymic). Researchers will use questionnaires to measure these factors and better understand how they affect quality of life. The goal is to…

This study looks at how the brain changes during a depression treatment called repetitive transcranial magnetic stimulation (rTMS). People receiving rTMS will have MRI brain scans before, during, and after their six-week treatment course. The scans will help researchers see wheth…

This study investigates how aging and schizophrenia influence metamemory—the ability to judge one's own memory accuracy. Researchers will compare four groups: younger and older adults with schizophrenia, and younger and older healthy controls. Participants will rate their confide…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This study followed survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how trauma affects the brain's ability to control unwanted memories. Researchers compared 216 survivors with people who were not exposed to the attacks. The goal was to u…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This study uses brain scans to explore how sleep and mood are connected in people with major depression compared to healthy volunteers. Participants undergo overnight sleep deprivation while researchers measure changes in brain activity, fluid flow, and mood. The goal is to uncov…

This trial tests whether adding role-play video demonstrations to an online course helps fifth-year medical students at Ain Shams University learn doctor-team communication skills. One group receives the standard online course, while the other also watches recorded videos showing…

This study investigates whether the hormone estradiol influences PTSD symptoms and brain activity related to fear and stress in women. Researchers will give some participants an estradiol patch and others a placebo before MRI scans that measure brain responses to threatening cues…

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This observational study looks at whether the types of bacteria living in the gut, along with diet and lifestyle, are linked to a person's risk of catching SARS-CoV-2. It follows over 900 children, their family members, and teachers in Spain for 17 months. Researchers collect sto…

This study investigates what makes cognitive-behavioral therapy effective for children and teens aged 7 to 16 with anxiety or depression. Researchers will analyze therapy sessions and outcomes to identify which techniques and processes lead to improvement. The goal is to understa…

This study tests very low, single doses of psilocybin—the active compound in magic mushrooms—in healthy adults to find a dose that is safe and does not cause psychedelic effects like hallucinations or altered consciousness. Participants receive either a low dose of psilocybin (ra…

This study explores how adults who stutter process and produce speech compared to those who do not. Participants complete computer-based listening and speaking tasks over one or two visits. The goal is to better understand the underlying differences in speech processing that may …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study tests whether a smartphone app can help doctors and patients make better medication choices for first-episode psychosis. Participants use the app to report symptoms and functioning in real time, giving clinicians up-to-date information to guide shared decisions. The go…

This study looks at how well university athletes sense their own body signals (like heartbeat or tension), their stress levels, anxiety, and sleep quality, and how these relate to physical tests like grip strength, jump height, flexibility, and balance. Researchers also check if …

This study tests whether a script-guided conversation before surgery helps patients and their families better understand general anesthesia, the anesthesiologist's role, and the risks they are consenting to. Adults having elective surgery under general anesthesia will receive the…

This study tests whether a training program for parents of children who have had a febrile convulsion (a seizure caused by fever) can lower parental anxiety and increase their knowledge about the condition. About 66 parents of children aged 6 months to 5 years will be randomly as…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This trial compares two high-intensity training programs—CrossFit and running-based HIIT—in elite male distance runners who live and train at moderate altitude. Over six weeks, participants train five days per week and undergo tests for aerobic fitness, strength, and blood marker…

This study examines whether levels of a blood enzyme called α-N-acetylgalactosaminidase differ between people with schizoaffective disorder during acute episodes and those in remission, compared to healthy individuals. The goal is to better understand the biological processes beh…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This study looks at whether children with ADHD are more likely to have very flexible joints (benign joint hypermobility) and if a certain blood marker differs. Researchers will compare 171 children aged 6 to 12—some with ADHD and some without—using physical exams and blood tests.…

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This study tested a two-day training program designed to help newly graduated nurses speak up about patient safety concerns. 76 nurses from a hospital in Ankara, Turkey, were split into two groups: one received the training, the other did not. Researchers measured changes in comm…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study looked at whether brain activity patterns can predict how well people with major depression or social anxiety respond to cognitive behavioral therapy (CBT). Over 200 participants were randomly assigned to 12 weeks of CBT or supportive therapy. Researchers measured brai…

This study tested a 10-week emotional intelligence program for first-year college students aged 18-25. The program aimed to improve how students identify, understand, use, and manage emotions. Researchers measured changes in emotional attention, clarity, and regulation, as well a…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study tested whether a role model-based ethics course could reduce moral injury and stress in 101 second-year medical students in Taiwan. Students chose between a standard version with stories and handouts, or an enhanced version with extra writing and guest speakers. Resear…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at 6 children with past PTSD to see if changes in attention and memory could predict a relapse. Researchers used computer tasks and standard tests to measure brain function. The goal is to find early warning signs so families can get help sooner.

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

This study surveys anesthesiologists to explore whether feelings of being a fraud (impostor phenomenon) are linked to everyday memory and attention lapses. Participants complete online questionnaires about impostor feelings, cognitive failures, anxiety, depression, sleep quality,…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study tested whether oxytocin nasal spray helps people with social anxiety disorder learn safety from watching others. About 120 adults received either oxytocin or a placebo and underwent brain scans. The goal was to see if oxytocin improves the brain's ability to tell threa…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …