Could adding abilify to antidepressants lift Treatment-Resistant depression?
NCT ID NCT00095758
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This phase 3 trial investigates whether adding aripiprazole (Abilify) to an antidepressant improves symptoms in adults with major depressive disorder who have not responded adequately to antidepressants alone. Participants take either aripiprazole or a placebo alongside their usual antidepressant for 6 weeks. The study measures changes in depression severity and daily functioning.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aripiprazole (Abilify)
- What this could lead to
- If successful, this could offer a new option for people with major depression who do not get enough relief from antidepressants alone.
- What could go wrong
- This is a relatively short trial (6 weeks of treatment), and the added benefit over placebo may be modest. Aripiprazole can cause side effects like weight gain, restlessness, and sleepiness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Local Institution
Beverly Hills, California, United States
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Local Institution
Burbank, California, United States
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Local Institution
National City, California, United States
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Local Institution
Orange, California, United States
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Pasadena, California, United States
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Denver, Colorado, United States
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Farmington, Connecticut, United States
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Jacksonville, Florida, United States
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Orlando, Florida, United States
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Atlanta, Georgia, United States
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Rockville, Maryland, United States
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Albuquerque, New Mexico, United States
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Brooklyn, New York, United States
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New York, New York, United States
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Cincinnati, Ohio, United States
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Toledo, Ohio, United States
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Portland, Oregon, United States
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Pittsburgh, Pennsylvania, United States
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Memphis, Tennessee, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Arlington, Virginia, United States
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Herndon, Virginia, United States
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Richmond, Virginia, United States
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Bellevue, Washington, United States
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Local Institution
Seattle, Washington, United States
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Local Institution
Brown Deer, Wisconsin, United States
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Local Institution
Middleton, Wisconsin, United States
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