Brain scans reveal how language therapy rewires Stroke-Damaged brains

NCT ID NCT01927302

Completed Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling, or sentence processing, and will undergo brain scans before and after treatment to track changes. The goal is to understand which therapies produce the best language recovery and how the brain adapts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: language treatment (naming, spelling, or sentence processing therapy)
What this could lead to: If successful, this could reveal which language therapies best rewire the brain after stroke, guiding more effective rehabilitation.
What could go wrong: This is an early-stage observational study with only 90 participants, so results may not apply to all people with aphasia. The therapies may not produce lasting improvements.

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Conditions

The condition(s) this trial relates to.

agraphia aphasia Aphasia, Broca dysgraphia nominal aphasia progressive non-fluent aphasia stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGRAMMATISM ANOMIA APHASIA DYSGRAPHIA STROKE

Contacts and locations

Locations

Boston University

Boston, Massachusetts, 02215, United States
Harvard University

Cambridge, Massachusetts, 02138, United States
Johns Hopkins University

Baltimore, Maryland, 21218, United States
Northwestern University

Chicago, Illinois, 60208, United States

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