Could nicotine patches lift depression in seniors?

NCT ID NCT05746273

Completed Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depression severity and brain activity using MRI scans and thinking tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine patch
What this could lead to: If it works, this could point toward a new way to improve thinking and mood in older adults with depression.
What could go wrong: This is a small, early-phase trial with only 60 people. Nicotine is addictive and can have side effects like skin irritation or sleep problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE DISORDER

Contacts and locations

Locations

Vanderbilt Psychiatric Hosptial

Nashville, Tennessee, 37212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.