Nerve zapping study reveals sex differences in depression stress response
NCT ID NCT04448327
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women. The goal was to understand how the treatment works, not to test a cure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Massachusetts General Hospital
Charlestown, Massachusetts, 02129, United States
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