Brain scans reveal clues about mental health disorders

NCT ID NCT02727972

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive tests and brain imaging over 1-2 months. The study did not test any treatment, but gathered information to guide future research.

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Conditions

The condition(s) this trial relates to.

bipolar disorder Depression major depressive disorder mood disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • PET Center

    New Haven, Connecticut, 06519, United States