Could magnesium cut opioid use after spine surgery?
NCT ID NCT04603638
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels and total morphine use are tracked over the first 24 hours to see if magnesium provides better pain control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
magnesium
What this could lead to
If magnesium works, it could offer a safer way to control pain after spinal surgery and reduce reliance on opioids like morphine.
What could go wrong
This is a small, early-stage study. Magnesium may not reduce pain or morphine use more than standard care, and side effects are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Istanbul University
Istanbul, 34093, Turkey (Türkiye)