Could magnesium cut opioid use after spine surgery?
NCT ID NCT04603638
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels and total morphine use are tracked over the first 24 hours to see if magnesium provides better pain control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- magnesium
- What this could lead to
- If magnesium works, it could offer a safer way to control pain after spinal surgery and reduce reliance on opioids like morphine.
- What could go wrong
- This is a small, early-stage study. Magnesium may not reduce pain or morphine use more than standard care, and side effects are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istanbul University
Istanbul, 34093, Turkey (Türkiye)
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