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Microdose of LSD may lift depression mood, early trial hints

NCT ID NCT07017478

Completed Symptom relief Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this approach offers a new way to ease symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LSD (lysergic acid diethylamide)
What this could lead to
If it works, this could point toward a new, low-dose treatment for depression that improves mood and sleep without the intense effects of higher doses.
What could go wrong
This is an early, small study (41 people) testing a single low dose. The effects may be weak or not last, and LSD can cause anxiety or discomfort even at low doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder hallucinogen-persisting perception disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION LSD MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • University of Chicago

    Chicago, Illinois, 60637, United States

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