Can brain tests predict who will beat stubborn depression?

NCT ID NCT02774980

Completed Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a new antidepressant, then again at 6 and 12 months. The goal was to find mental markers that help doctors choose better treatments for people who haven't gotten relief from standard therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict which depression treatments will work for patients who haven't responded to previous therapies.
What could go wrong: This is a small, observational study with only 30 participants. It does not test a new treatment, so it may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Hopital Pasteur

Nice, 06000, France

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