Could a synthetic DMT analog ease severe anxiety? small trial begins
NCT ID NCT06051721
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 3 times
Summary
This phase 2a trial tests CYB004, a synthetic version of the psychedelic DMT, combined with talk therapy in 36 adults with moderate-to-severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms compared to an active control. Participants must be on a stable dose of anxiety medication and have not responded well enough to prior treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CYB004 (a synthetic deuterated DMT analog) plus psychotherapy
- What this could lead to
- If successful, this could point toward a new, fast-acting treatment option for generalized anxiety disorder that combines a psychedelic-like drug with talk therapy.
- What could go wrong
- This is a small, early-phase proof-of-concept trial with only 36 participants. The drug may not prove more effective than existing treatments, and psychedelic-like side effects could be challenging for some.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cedar Clinical Research
Murray, Utah, 84107, United States
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CenExel ACMR
Atlanta, Georgia, 30331, United States
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Innovative Clinical Research, Inc.
Miami Lakes, Florida, 33016, United States
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Research Centers of America
Hollywood, Florida, 33024, United States
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Uptown Research Institute
Chicago, Illinois, 60640, United States
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iResearch Atlanta
Decatur, Georgia, 30330, United States
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