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Ear nerve stimulation may soothe period pain and mood

NCT ID NCT07683637

Completed Symptom relief Sponsor: Istanbul Gelisim University Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce menstrual pain, depression, and anxiety in young women with primary dysmenorrhea (painful periods without an underlying condition). Participants receive either real or sham stimulation over 10 sessions during the luteal phase of their cycle. The goal is to see if this approach can improve pain, pain threshold, and emotional well-being.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcutaneous auricular vagus nerve stimulation (taVNS) device
What this could lead to
If it works, this could offer a drug-free option for managing period pain and related mood symptoms.
What could go wrong
This is a small, early-stage trial with only 40 participants. The effect may be small or no better than a placebo, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression Dysmenorrhea primary dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY DYSMENORRHEA PRIMARY DYSMENORRHEA (PD)

Contacts and locations

Locations

  • Istanbul Gelisim University

    Istanbul, Avcılar, Turkey (Türkiye)

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