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Ear nerve stimulation may soothe period pain and mood

NCT ID NCT07683637

Symptom relief Sponsor: Istanbul Gelisim University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce menstrual pain, depression, and anxiety in young women with primary dysmenorrhea (painful periods without an underlying condition). Participants receive either real or sham stimulation over 10 sessions during the luteal phase of their cycle. The goal is to see if this approach can improve pain, pain threshold, and emotional well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous auricular vagus nerve stimulation (taVNS) device
What this could lead to
If it works, this could offer a drug-free option for managing period pain and related mood symptoms.
What could go wrong
This is a small, early-stage trial with only 40 participants. The effect may be small or no better than a placebo, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jun 2023

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged 18 years and older * Diagnosed with primary dysmenorrhea (PD) * Having regular menstrual cycles within the last 6 months * Reporting menstrual pain intensity of at least 40 mm on the Visual Analog Scale (VAS) * Willingness to participate in the study and providing informed consent Exclusion Criteria: * Diagnosis of secondary dysmenorrhea * Irregular menstrual cycles * Menstrual cycle length shorter than 21 days or longer than 35 days * History of pregnancy or childbirth, or current pregnancy * Use of intrauterine device (IUD) or oral contraceptives * Current use of sedative, analgesic, anti-inflammatory, or psychotropic medication * History of pelvic surgery or presence of pelvic pathology * Presence of chronic, systemic, cardiovascular, or neurological diseases (e.g., diabetes mellitus, hypoglycemia, bradycardia, hypotension, hypotonic disorders, etc.) * Presence of ear implants, ear wounds, or ear infections * Presence of implanted electronic devices such as pacemakers

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression Dysmenorrhea primary dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary dysmenorrhea Primary dysmenorrhea (PD)

Contacts and locations

Locations

  • Istanbul Gelisim University

    Istanbul, Avcılar, Turkey (Türkiye)

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