Primary dysmenorrhea

This study tests two self-care methods—virtual ear acupressure and Baduanjin qigong—to prevent or reduce period pain in 145 women aged 16–35 with primary dysmenorrhea. Participants will be randomly assigned to one of three groups and practice their assigned technique for 12 weeks…

This study tests whether telerehabilitation-based cognitive exercise therapy and yoga can reduce pain, improve physical function, and boost quality of life in adolescent girls with primary dysmenorrhea (painful periods). Forty-two teens aged 10–19 will participate in 12 weeks of …

This study tests whether connective tissue massage or music-based relaxation can reduce pain and other symptoms in women with primary dysmenorrhea (painful periods). Thirty-six women will be randomly assigned to massage, relaxation, or a control group. The treatments are given be…

This study looks at whether aerobic exercise or a relaxation method (Jacobson's technique) works better for reducing pain, tiredness, and improving daily life in young women with painful periods. About 58 women aged 17-24 with mild period pain will be randomly placed into one of …

This trial tests whether graded motor imagery—a brain-training program that includes recognizing body positions, imagining pain-free movements, and using mirror therapy—can reduce pain sensitivity and intensity in women with primary dysmenorrhea (painful periods with no medical c…

This study tests two manual therapy techniques—sacral release and lumbar mobilization—in 46 unmarried women with primary dysmenorrhea (painful periods). The goal is to see which better reduces pain, symptom severity, and improves quality of life over six weeks. Participants recei…

This study tests a non-invasive manual therapy called pelvic nerve mobilization to reduce menstrual pain in 60 women aged 18-30 with primary dysmenorrhea. Participants will receive either the active therapy or a sham treatment over three cycles. The goal is to see if this drug-fr…

This study tests whether a 12-week online high-intensity interval training (HIIT) program can reduce menstrual pain and improve quality of life in women with primary dysmenorrhea (painful periods). Sixty women will be split into two groups: one gets an educational workshop plus t…

This study tests whether watching and following along with laughter yoga videos can reduce pain and other menstrual symptoms in young women with primary dysmenorrhea (painful periods). Researchers will randomly assign 68 university students aged 18-24 to either a laughter yoga gr…

This study tests whether pressing on specific body spots (acupressure) can reduce menstrual pain and PMS symptoms in women aged 18-30. About 120 participants will either do real or fake acupressure at home for 6 months. The goal is to see if this simple, drug-free method can help…

This study tests whether injecting botulinum toxin (Botox) into the uterine muscle can reduce severe period pain in women who haven't found relief from standard treatments. 222 women will receive either Botox or a placebo injection via a small camera inserted into the uterus. The…

This study tests whether a non-invasive nerve stimulation technique, called transcutaneous tibial nerve stimulation (TTNS), can reduce pain and improve quality of life in women with primary dysmenorrhea (painful periods). Thirty-two women aged 20-25 will receive either TTNS plus …

This Phase 3 trial is testing a new drug called CDE100 to see if it relieves menstrual cramp pain better than a current treatment (Buscopan Composto). About 238 women aged 16-35 with moderate to severe cramps will take part. The study is double-blind, meaning neither participants…

This study tests whether intravenous magnesium sulfate can quickly reduce severe period pain in women visiting the emergency room. Sixty women with acute dysmenorrhea will receive either magnesium or a standard painkiller (dexketoprofen). Pain levels are measured before and one h…

This study compares three approaches to reduce menstrual pain in women aged 18-25 with primary dysmenorrhea: exercise alone, exercise plus motor imagery (mentally practicing movements), and exercise plus pain neuroscience education. Over 8 weeks, 51 participants will attend super…

This study tests whether a technique called Doppler-guided angiopuncture can safely reduce pain in women with primary dysmenorrhea (period pain). Researchers will perform the needle procedure on 30 participants and measure pain changes using a standard pain scale. The goal is to …

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if …

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study looks at whether women with painful periods have worse knee joint awareness and balance compared to those without pain. Researchers will measure balance and knee position sense in 62 healthy young women. No treatment is given—this is purely an observation to better und…

This study looks at whether women with painful periods have different hip movement and strength when a pain stimulus is applied, compared to women without period pain. Researchers will measure hip range of motion, ankle strength, and heart rate changes before and after a brief va…