Tylenol vs. advil: which is safer for period cramps in Crohn's?

NCT ID NCT07337902

Recruiting now Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if a larger, more definitive study is possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetaminophen and ibuprofen
What this could lead to: If successful, this pilot could pave the way for a larger study that helps determine which painkiller is safer and more effective for period cramps in women with Crohn's disease.
What could go wrong: This is a very small pilot study (24 people) focused on feasibility, not on proving which drug works better. Results may not apply to all women with Crohn's disease.

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Conditions

The condition(s) this trial relates to.

Crohn disease primary dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE (CD) DYSMENORRHEA PRIMARY

Contacts and locations

Locations

University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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