Can upadacitinib sustain remission in Crohn's disease?

NCT ID NCT02782663

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study is testing whether upadacitinib, an oral medication, can safely and effectively manage Crohn's disease over the long term. Participants who completed a previous year-long study will continue taking the drug and be monitored for up to a year. The goal is to see if the drug helps maintain or achieve remission of the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: upadacitinib (also known as RINVOQ), an oral tablet
What this could lead to: If successful, this could support upadacitinib as a long-term treatment option for Crohn's disease, potentially improving remission rates and quality of life.
What could go wrong: This is a phase 2 open-label extension, meaning results are preliminary and may not confirm long-term benefits. Risks include potential side effects and the possibility that the drug may not work for all patients.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE (CD)

Contacts and locations

Locations

Amsterdam UMC, locatie AMC /ID# 149932

Amsterdam, North Holland, 1105 AZ, Netherlands
Aspen Clinical Research /ID# 150020

Orem, Utah, 84058, United States
CHRU Lille - Hopital Claude Huriez /ID# 149897

Lille, Nord, 59037, France
Cabinet Particular Policlinic Algomed /ID# 149993

Timișoara, 300002, Romania
Charm City Research Group /ID# 150040

Towson, Maryland, 21204, United States
Clin Res Inst of Michigan, LLC /ID# 150008

Chesterfield, Michigan, 48047, United States
Cotton O'Neil Clinical Research Center, Digestive Health /ID# 149900

Topeka, Kansas, 66606, United States
DRK Kliniken Berlin Westend /ID# 149905

Berlin, 14050, Germany
Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 149871

Montreal, Quebec, H4A 3J1, Canada
Dunedin Hospital /ID# 149964

Otago, Otago, 9016, New Zealand
Duplicate_(G.I.R.I.) GI Research Institute Foundation /ID# 149878

Vancouver, British Columbia, V6Z 2K5, Canada
Duplicate_Aarhus University Hospital /ID# 149919

Aarhus N, Central Jutland, 8200, Denmark
Duplicate_CHRU Nancy - Hopitaux de Brabois /ID# 149896

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France
Duplicate_CHU Amiens-Picardie Site Sud /ID# 149921

Amiens, Somme, 80054, France
Duplicate_CHU de Liege /ID# 149912

Liège, Liege, 4000, Belgium
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 149958

Bologna, Emilia-Romagna, 40138, Italy
Duplicate_KM Management, spol. s.r.o. /ID# 149949

Nitra, Nitra Region, 949 01, Slovakia
Duplicate_Manchester University NHS Foundation Trust /ID# 150006

Manchester, Manchester, M13 9WL, United Kingdom
Duplicate_University of Florida - Archer /ID# 150033

Gainesville, Florida, 32610, United States
Duplicate_University of Louisville /ID# 149884

Louisville, Kentucky, 40202, United States
GI Specialists of GA, PC /ID# 150015

Marietta, Georgia, 30060, United States
Gastro I., s.r.o. /ID# 149948

Prešov, Presov, 080 01, Slovakia
Gastroenterology Associates of Central Georgia, LLC /ID# 149870

Macon, Georgia, 31201, United States
Hepato-Gastroenterologie HK, s.r.o. /ID# 149882

Hradec Králové, Hradec Kralove, 500 12, Czechia
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 149996

Ferrol, A Coruna, 15405, Spain
Hospital Universitario La Paz /ID# 149997

Madrid, Madrid, 28046, Spain
Investigative Clinical Research /ID# 149886

Annapolis, Maryland, 21401, United States
Kansas City Research Institute /ID# 149888

Kansas City, Missouri, 64131, United States
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 149890

Hvidovre, Capital Region, 2650, Denmark
Lovisenberg Diakonale Sykehus /ID# 149967

Oslo, Oslo, 0440, Norway
Magyar Elhizastudomanyi Kozpont Kft. /ID# 149907

Budapest, 1124, Hungary
Mayo Clinic - Rochester /ID# 149894

Rochester, Minnesota, 55905-0001, United States
Medizinisches Versorgungszentrum Portal 10 /ID# 149930

Münster, 48155, Germany
NYU Langone Long Island Clinical Research Associates /ID# 149976

Lake Success, New York, 11042, United States
Nature Coast Clinical Research - Inverness /ID# 149975

Inverness, Florida, 34452-4717, United States
Options Health Research, LLC /ID# 150010

Tulsa, Oklahoma, 74104, United States
Oxford University Hospitals NHS Foundation Trust /ID# 149963

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 149978

Warsaw, Masovian Voivodeship, 02-507, Poland
Rabin Medical Center. /ID# 149942

Petah Tikva, 4941492, Israel
Santa Sp. z o.o. Santa Familia Centrum Badan, Profilaktyki i Leczenia /ID# 149979

Lodz, Łódź Voivodeship, 90-302, Poland
Texas Digestive Disease Consultants - Southlake /ID# 149869

Southlake, Texas, 76092, United States
Texas Digestive Disease Consultants - Southlake /ID# 149989

Southlake, Texas, 76092, United States
The Chaim Sheba Medical Center /ID# 149945

Ramat Gan, Tel Aviv, 5265601, Israel
The Ctr for Gastro Disorders /ID# 150012

Hollywood, Florida, 33021, United States
Toronto Digestive Disease Associates /ID# 149877

Vaughan, Ontario, L4L 4Y7, Canada
UC San Diego Health System /ID# 150041

La Jolla, California, 92037, United States
Univ California, San Francisco /ID# 149987

San Francisco, California, 94143-2204, United States
Univ NC Chapel Hill /ID# 149982

Chapel Hill, North Carolina, 27514-4220, United States
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 149936

Kiel, Schleswig-Holstein, 24105, Germany
Universitair Medisch Centrum Utrecht /ID# 149933

Utrecht, Utrecht, 3584 CX, Netherlands
University Of Cincinnati Medical Center /ID# 149977

Cincinnati, Ohio, 45219, United States
University of Alberta Hospital /ID# 149873

Edmonton, Alberta, T6G 2B7, Canada
University of British Columbia (UBC) - Gordon and Leslie Diamond Health Care Ce /ID# 149876

Vancouver, British Columbia, V5Z 1M9, Canada
University of Catanzaro /ID# 149927

Catanzaro, Calabria, 88100, Italy
University of Virginia /ID# 149881

Charlottesville, Virginia, 22908, United States
University of Washington /ID# 149988

Seattle, Washington, 98109, United States
Virginia Mason Hospital & Medical Center /ID# 150042

Seattle, Washington, 98101, United States
Washington University-School of Medicine /ID# 149899

St Louis, Missouri, 63110, United States
Weill Cornell Medicine/NYP /ID# 149895

New York, New York, 10021-4872, United States
Wisconsin Center for Advanced Research /ID# 149863

Milwaukee, Wisconsin, 53215, United States
Yitzhak Shamir Medical Center /ID# 149943

Ẕerifin, Central District, 70300, Israel

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