Menstrual disorder

This study tests an experimental drug called mibavademab in 34 women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress or intense exercise. The goal is to see if the drug can help the body produce the hormones needed for ovulation and imp…

This study tests a two-step treatment for functional hypothalamic amenorrhea, a condition where women stop having periods due to stress, low weight, or excessive exercise. It combines Western medicine to quickly restart menstruation with Chinese herbs to support long-term balance…

This study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…

This study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …

This study tests whether two natural supplements, myo-Inositol and Dioscorea Villosa, can help teenagers aged 14-19 with irregular menstrual cycles, including those with PCOS. The goal is to see if these supplements can make periods more regular. The trial is small, with only 20 …

This study tests whether kisspeptin, a natural hormone, can trigger the release of other reproductive hormones and help women with hypothalamic amenorrhea (missing periods) release eggs. Twenty women will receive daily injections of kisspeptin for two weeks, with frequent blood t…

This study compares two ways to prepare the womb lining for frozen embryo transfer in women with irregular menstrual cycles. One method uses letrozole pills to stimulate natural egg growth, while the other uses artificial hormones. The goal is to see which approach leads to more …

This study tests two self-care methods—virtual ear acupressure and Baduanjin qigong—to prevent or reduce period pain in 145 women aged 16–35 with primary dysmenorrhea. Participants will be randomly assigned to one of three groups and practice their assigned technique for 12 weeks…

This study tests whether telerehabilitation-based cognitive exercise therapy and yoga can reduce pain, improve physical function, and boost quality of life in adolescent girls with primary dysmenorrhea (painful periods). Forty-two teens aged 10–19 will participate in 12 weeks of …

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study tests whether connective tissue massage or music-based relaxation can reduce pain and other symptoms in women with primary dysmenorrhea (painful periods). Thirty-six women will be randomly assigned to massage, relaxation, or a control group. The treatments are given be…

This study tests whether somatic movement therapy or core strengthening exercises better reduce PMS symptoms, stress, and improve quality of life. Thirty-six women aged 18-35 with PMS will do one of the two programs for six weeks. Researchers will measure changes using standard q…

This study looks at whether aerobic exercise or a relaxation method (Jacobson's technique) works better for reducing pain, tiredness, and improving daily life in young women with painful periods. About 58 women aged 17-24 with mild period pain will be randomly placed into one of …

This trial tests whether graded motor imagery—a brain-training program that includes recognizing body positions, imagining pain-free movements, and using mirror therapy—can reduce pain sensitivity and intensity in women with primary dysmenorrhea (painful periods with no medical c…

This study looks at whether whole-body vibration exercises combined with relaxation techniques can help adolescent female athletes who have Female Athlete Triad Syndrome—a condition involving low bone density, irregular periods, and low energy. About 50 participants will follow a…

This study tests two manual therapy techniques—sacral release and lumbar mobilization—in 46 unmarried women with primary dysmenorrhea (painful periods). The goal is to see which better reduces pain, symptom severity, and improves quality of life over six weeks. Participants recei…

This study tests whether guided imagery—a relaxation technique using mental images—can reduce the physical and emotional symptoms of premenstrual syndrome (PMS) in university students. Forty-eight women with regular cycles and moderate-to-severe PMS will practice guided imagery a…

This study tests whether a special pain consultation and education session can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive the new consultation plus usual care, or usual care alone. They w…

This study tests a non-invasive manual therapy called pelvic nerve mobilization to reduce menstrual pain in 60 women aged 18-30 with primary dysmenorrhea. Participants will receive either the active therapy or a sham treatment over three cycles. The goal is to see if this drug-fr…

This study tests whether a 12-week online high-intensity interval training (HIIT) program can reduce menstrual pain and improve quality of life in women with primary dysmenorrhea (painful periods). Sixty women will be split into two groups: one gets an educational workshop plus t…

This study looks at whether acupuncture can help young women (ages 15-40) with cancer get their periods back after chemotherapy caused them to stop. About 60 participants will receive acupuncture or usual care. Researchers will measure how many people join and finish the study, a…

This study tests whether watching and following along with laughter yoga videos can reduce pain and other menstrual symptoms in young women with primary dysmenorrhea (painful periods). Researchers will randomly assign 68 university students aged 18-24 to either a laughter yoga gr…

This study tests whether coloring mandalas or listening to classical music can reduce premenstrual syndrome (PMS) symptoms and improve quality of life. 108 female students with PMS will be split into three groups: mandala coloring, music listening, or no intervention. The trial i…

This study tests whether pressing on specific body spots (acupressure) can reduce menstrual pain and PMS symptoms in women aged 18-30. About 120 participants will either do real or fake acupressure at home for 6 months. The goal is to see if this simple, drug-free method can help…

This study tests whether injecting botulinum toxin (Botox) into the uterine muscle can reduce severe period pain in women who haven't found relief from standard treatments. 222 women will receive either Botox or a placebo injection via a small camera inserted into the uterus. The…

This study tests whether a non-invasive nerve stimulation technique, called transcutaneous tibial nerve stimulation (TTNS), can reduce pain and improve quality of life in women with primary dysmenorrhea (painful periods). Thirty-two women aged 20-25 will receive either TTNS plus …

This phase 2 trial tests whether a transdermal patch containing ethinyl estradiol and norelgestromin can stop irregular vaginal bleeding in women using contraceptive implants. Forty women over 18 who have abnormal bleeding will apply the patch or a placebo for 21 days. Researcher…

This Phase 3 trial is testing a new drug called CDE100 to see if it relieves menstrual cramp pain better than a current treatment (Buscopan Composto). About 238 women aged 16-35 with moderate to severe cramps will take part. The study is double-blind, meaning neither participants…

This study tests whether intravenous magnesium sulfate can quickly reduce severe period pain in women visiting the emergency room. Sixty women with acute dysmenorrhea will receive either magnesium or a standard painkiller (dexketoprofen). Pain levels are measured before and one h…

This study compares three approaches to reduce menstrual pain in women aged 18-25 with primary dysmenorrhea: exercise alone, exercise plus motor imagery (mentally practicing movements), and exercise plus pain neuroscience education. Over 8 weeks, 51 participants will attend super…

This study tests whether a technique called Doppler-guided angiopuncture can safely reduce pain in women with primary dysmenorrhea (period pain). Researchers will perform the needle procedure on 30 participants and measure pain changes using a standard pain scale. The goal is to …

This 24-week study is testing two herbal supplements, Elix Cycle Balance and Elix Daily Harmony, in 42 women aged 20-45 with uterine fibroids. Participants take the supplements daily and report changes in symptoms like menstrual pain and bleeding through questionnaires. The goal …

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study looks at how non-food-related stressors (like work or emotional stress) affect menstrual health in pre-menopausal women. Researchers will measure stress hormones and sex hormones in 600 women over 6 months. The goal is to understand if stress directly causes menstrual …

This study from Johns Hopkins aims to find epigenetic markers in blood that could help identify premenstrual dysphoric disorder (PMDD). Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women — some with PMDD and some without. The goa…

This study looks at how brain chemicals called neuroactive steroids change across the menstrual cycle in women with Premenstrual Dysphoric Disorder (PMDD) compared to healthy women. It also tests whether a low-dose antidepressant (sertraline) affects these chemical levels. The go…

This study looks at how exercising without eating beforehand (fasted) might change menstrual hormones and cycle length in women who regularly run or cycle. Over about 3 months, 64 participants will track their cycles, complete three 90-minute exercise sessions either fed or faste…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if …

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study looks at how increasing exercise or adding mental stress might change menstrual cycles in women who run or cycle regularly. Over about three months, participants either keep their normal routine, increase weekly mileage by 30%, do stressful thinking tasks, or both. The…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study looks at whether women with painful periods have worse knee joint awareness and balance compared to those without pain. Researchers will measure balance and knee position sense in 62 healthy young women. No treatment is given—this is purely an observation to better und…

This study is looking at 60 women who are getting a hormone-releasing IUD (LNG-IUD) to see if the timing of insertion during their menstrual cycle affects whether they develop ovarian cysts. Researchers will use ultrasound to check for cysts at 0, 3, 6, and 12 months after insert…

This study is building a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops having periods due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how common FHA is…

This study looks at whether women with painful periods have different hip movement and strength when a pain stimulus is applied, compared to women without period pain. Researchers will measure hip range of motion, ankle strength, and heart rate changes before and after a brief va…