Premenstrual tension
MONDO:0004169A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.
Also known as: PMS, premenstrual syndrome
40 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Wearable Brain-Zapping device aims to ease Period-Related mood and brain fog
Symptom relief Recruiting nowThis study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…
Sponsor: Samphire Group, Inc. • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
-
Can gentle movement beat core workouts for PMS relief?
Symptom relief Recruiting nowThis study tests whether somatic movement therapy or core strengthening exercises better reduce PMS symptoms, stress, and improve quality of life. Thirty-six women aged 18-35 with PMS will do one of the two programs for six weeks. Researchers will measure changes using standard q…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
-
Mind over menstruation: could guided imagery beat PMS?
Symptom relief Recruiting nowThis study tests whether guided imagery—a relaxation technique using mental images—can reduce the physical and emotional symptoms of premenstrual syndrome (PMS) in university students. Forty-eight women with regular cycles and moderate-to-severe PMS will practice guided imagery a…
Phase: NA • Sponsor: Baskent University • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
-
Art and music: a new remedy for PMS?
Symptom relief Recruiting nowThis study tests whether coloring mandalas or listening to classical music can reduce premenstrual syndrome (PMS) symptoms and improve quality of life. 108 female students with PMS will be split into three groups: mandala coloring, music listening, or no intervention. The trial i…
Phase: NA • Sponsor: Rukiye Duman • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
-
Pressing points for period pain: new study tests Self-Acupressure
Symptom relief Recruiting nowThis study tests whether pressing on specific body spots (acupressure) can reduce menstrual pain and PMS symptoms in women aged 18-30. About 120 participants will either do real or fake acupressure at home for 6 months. The goal is to see if this simple, drug-free method can help…
Phase: NA • Sponsor: Nigde Omer Halisdemir University • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
-
Blood test for PMDD on the horizon? johns hopkins launches biomarker study
Knowledge-focused Recruiting nowThis study from Johns Hopkins aims to find epigenetic markers in blood that could help identify premenstrual dysphoric disorder (PMDD). Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women — some with PMDD and some without. The goa…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
Scientists probe brain chemistry behind severe PMS to unlock better treatments
Knowledge-focused Recruiting nowThis study looks at how brain chemicals called neuroactive steroids change across the menstrual cycle in women with Premenstrual Dysphoric Disorder (PMDD) compared to healthy women. It also tests whether a low-dose antidepressant (sertraline) affects these chemical levels. The go…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
Brain scans and stress tests aim to unravel PMDD vs depression
Knowledge-focused Recruiting nowThis study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…
Sponsor: University Hospital Tuebingen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
-
25,000 ultrasound scans to train AI for better Women's health diagnosis
Knowledge-focused Recruiting nowThis study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC