Botox in the womb: a new hope for crippling period pain?

NCT ID NCT06995287

Recruiting now Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests whether injecting botulinum toxin (Botox) into the uterine muscle can reduce severe period pain in women who haven't found relief from standard treatments. 222 women will receive either Botox or a placebo injection via a small camera inserted into the uterus. The main goal is to see if women feel significantly better after 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botulinum toxin (Botox)
What this could lead to: If it works, this could offer a new, long-lasting pain relief option for women with severe period pain who haven't been helped by standard treatments.
What could go wrong: This is still an experimental procedure with risks from the injection itself. The placebo group may also show improvement, and the effect may not last beyond a few months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

primary dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PELVIC PAIN PRIMARY DYSMENORRHEA

Contacts and locations

Locations

CHU Angers
RECRUITING

Angers, France
CHU Brest
RECRUITING

Brest, France
CHU Lille
RECRUITING

Lille, France
CHU Nantes
RECRUITING

Nantes, France
CHU Rennes
NOT_YET_RECRUITING

Rennes, France
Clinique Brétéché
RECRUITING

Nantes, France
Clinique axium / Centre resilience
RECRUITING

Aix-en-Provence, France
Hôpital de la Croix-Rousse
RECRUITING

Lyon, France

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