Functional hypothalamic amenorrhea
MONDO:1060210A form of secondary amenorrhea caused by suppression of the hypothalamic-pituitary-ovarian axis without identifiable organic pathology, typically associated with energy deficiency, excessive exercise, psychological stress, or low body weight.
16 clinical trials for this condition and its sub-types.
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New drug aims to restart periods in women with exercise-related amenorrhea
Disease control Recruiting nowThis study tests an experimental drug called mibavademab in 34 women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress or intense exercise. The goal is to see if the drug can help the body produce the hormones needed for ovulation and imp…
Phase: PHASE2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New study combines eastern and western medicine to restore periods in women
Disease control Recruiting nowThis study tests a two-step treatment for functional hypothalamic amenorrhea, a condition where women stop having periods due to stress, low weight, or excessive exercise. It combines Western medicine to quickly restart menstruation with Chinese herbs to support long-term balance…
Phase: PHASE4 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New hope for young women with bone loss from missed periods
Disease control Recruiting nowThis study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…
Phase: PHASE3 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Can a patch beat a pill? new study aims to strengthen bones in women with hormone imbalance
Disease control Recruiting nowThis study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …
Phase: PHASE2 • Sponsor: University of Virginia • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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Could a natural hormone restart periods in women with hypothalamic amenorrhea?
Disease control Recruiting nowThis study tests whether kisspeptin, a natural hormone, can trigger the release of other reproductive hormones and help women with hypothalamic amenorrhea (missing periods) release eggs. Twenty women will receive daily injections of kisspeptin for two weeks, with frequent blood t…
Phase: PHASE2 • Sponsor: Stephanie B. Seminara, MD • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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25,000 ultrasound scans to train AI for better Women's health diagnosis
Knowledge-focused Recruiting nowThis study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Massive new registry aims to uncover hidden causes of missed periods
Knowledge-focused Recruiting nowThis study is building a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops having periods due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how common FHA is…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC