Amenorrhea

This study tests an experimental drug called mibavademab in 34 women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress or intense exercise. The goal is to see if the drug can help the body produce the hormones needed for ovulation and imp…

This study tests a two-step treatment for functional hypothalamic amenorrhea, a condition where women stop having periods due to stress, low weight, or excessive exercise. It combines Western medicine to quickly restart menstruation with Chinese herbs to support long-term balance…

This study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…

This study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …

This study tests whether two natural supplements, myo-Inositol and Dioscorea Villosa, can help teenagers aged 14-19 with irregular menstrual cycles, including those with PCOS. The goal is to see if these supplements can make periods more regular. The trial is small, with only 20 …

This study tests whether kisspeptin, a natural hormone, can trigger the release of other reproductive hormones and help women with hypothalamic amenorrhea (missing periods) release eggs. Twenty women will receive daily injections of kisspeptin for two weeks, with frequent blood t…

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study looks at how increasing exercise or adding mental stress might change menstrual cycles in women who run or cycle regularly. Over about three months, participants either keep their normal routine, increase weekly mileage by 30%, do stressful thinking tasks, or both. The…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study is building a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops having periods due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how common FHA is…