Can a bone drug help young women with stress-related period loss?

NCT ID NCT06533865

First seen Nov 01, 2025 · Last updated May 02, 2026 · Updated 24 times

Summary

This study tests if adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to stress, intense exercise, or eating disorders. Participants receive either romosozumab or placebo for 6 months, plus estrogen patches and progesterone pills, followed by one IV bone-strengthening infusion. The goal is to see if bone density improves more with the active drug over one year compared to placebo and to healthy peers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Virginia Medical Center

    RECRUITING

    Charlottesville, Virginia, 22903, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

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