New study tests letrozole to boost IVF success in women with irregular cycles

NCT ID NCT06372119

Recruiting now Disease control Sponsor: Mỹ Đức Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways to prepare the womb lining for frozen embryo transfer in women with irregular menstrual cycles. One method uses letrozole pills to stimulate natural egg growth, while the other uses artificial hormones. The goal is to see which approach leads to more live births. About 790 women aged 18-42 will take part, and each will receive one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letrozole (Femara or Lezra) and micronized progesterone
What this could lead to: If letrozole works better, it could offer a simpler, more natural hormone preparation for frozen embryo transfer, potentially increasing live birth rates in women with irregular cycles.
What could go wrong: This is a single trial with 790 participants, so results may not apply to all women. Letrozole can cause side effects like hot flashes or fatigue, and the study doesn't guarantee a higher live birth rate.

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Conditions

The condition(s) this trial relates to.

menstrual disorder Menstruation Disturbances

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMBRYO TRANSFER HORMONE REPLACEMENT THERAPY IRREGULAR MENSTRUATION LETROZOLE

Contacts and locations

Locations

My Duc Hospital
RECRUITING

Ho Chi Minh City, Ho Chi Minh City, 70000, Vietnam
My Duc Phu Nhuan Hospital
RECRUITING

Ho Chi Minh City, Ho Chi Minh City, 70000, Vietnam

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