New study tests letrozole to boost IVF success in women with irregular cycles
NCT ID NCT06372119
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to prepare the womb lining for frozen embryo transfer in women with irregular menstrual cycles. One method uses letrozole pills to stimulate natural egg growth, while the other uses artificial hormones. The goal is to see which approach leads to more live births. About 790 women aged 18-42 will take part, and each will receive one of the two treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Letrozole (Femara or Lezra) and micronized progesterone
What this could lead to
If letrozole works better, it could offer a simpler, more natural hormone preparation for frozen embryo transfer, potentially increasing live birth rates in women with irregular cycles.
What could go wrong
This is a single trial with 790 participants, so results may not apply to all women. Letrozole can cause side effects like hot flashes or fatigue, and the study doesn't guarantee a higher live birth rate.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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My Duc Hospital
RECRUITINGHo Chi Minh City, Ho Chi Minh City, 70000, Vietnam
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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My Duc Phu Nhuan Hospital
RECRUITINGHo Chi Minh City, Ho Chi Minh City, 70000, Vietnam
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••