Could a fibroid drug help women with adenomyosis finally achieve a live birth?
NCT ID NCT07698561
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests whether taking linzagolix (Yselty) for 3 to 6 months before an embryo transfer can improve live birth rates in women with adenomyosis who have experienced repeated implantation failure. Adenomyosis can make the womb lining less receptive to embryos, even when the embryos are high-quality. The trial will follow 35 women across three fertility clinics in Spain, measuring pregnancy and live birth outcomes, as well as changes in the womb's structure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- linzagolix (Yselty)
- What this could lead to
- If successful, this could offer a new pre-treatment option to improve pregnancy and live birth rates in women with adenomyosis who have repeatedly failed embryo transfers.
- What could go wrong
- This is a small, early-phase study with only 35 participants, so results may not apply broadly. Linzagolix is used off-label here, and its benefits for adenomyosis prior to embryo transfer are not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Vida Fertility Alicante
Alicante, Alicante, 03008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vida Fertility Donostia
San Sebastián, Gipuzkoa, 20018, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vida Fertility Institute Madrid
Madrid, Madrid, 28043, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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