Female infertility

This study tests whether a temporary uterus transplant from a living donor can allow women with uterine factor infertility—who lack a functioning uterus—to become pregnant and deliver a healthy baby. Recipients receive immunosuppressive drugs to prevent rejection, and the uterus …

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study compares two common ovarian stimulation protocols used during IVF in women with polycystic ovary syndrome (PCOS). The PPOS protocol uses a progestin hormone to suppress ovulation, while the antagonist protocol uses a different drug. Researchers will track which method …

This study compares a longer course of the fertility drug Clomid against the standard short course for women with diminished ovarian reserve undergoing IVF. The goal is to see if the extended protocol leads to more mature eggs retrieved while reducing the number of injections and…

This phase 3 study tests a new weekly growth hormone injection (inpegsomatropin) against an existing one (givopegsomatropin) in 84 girls with Turner syndrome who have short stature. The goal is to see which works better for increasing growth over 52 weeks. Participants are prepub…

This study tests whether transplanting a woman's own previously frozen ovarian tissue can restore fertility and normal hormone levels after chemotherapy or radiation caused ovarian failure. Five women who had ovarian tissue frozen before cancer treatment will receive the tissue b…

This trial investigates whether infusing a woman's own platelet-rich plasma (PRP) into her ovaries can improve egg production and hormone levels in those with poor ovarian response to fertility treatments. The study involves 100 women who have had difficulty producing enough eggs…

This study investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can improve egg production and hormone levels. It includes women aged 40 and older who have a poor response to standard fertility treatments. Participants receive either PRP or a p…

This trial investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can restart menstrual cycles and improve hormone levels. It includes 100 women under 40 with premature ovarian failure (early menopause). Participants receive either PRP or a place…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) or platelet-free plasma (PFP) into her ovaries can restart menstrual cycles and improve hormone levels. The trial includes 100 women aged 45-55 who have been in menopause for at least a year. Researchers …

This study investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can restart regular menstrual cycles and improve hormone levels. The trial includes perimenopausal women aged 40 and older who have irregular cycles or elevated FSH. Participants r…

This study tests whether taking alpha-lipoic acid (ALA), a powerful antioxidant, for two months before IVF can improve egg quality and pregnancy rates in women aged 35-45 with infertility. Researchers will compare 30 women who take ALA with 30 who do not, measuring embryo quality…

This study tests whether a uterus from a deceased donor can be transplanted into women who cannot get pregnant due to a missing or non-working uterus. Participants must first create and freeze at least six embryos through IVF. After transplant and recovery, embryos are implanted.…

This study aims to help 10 women with absolute uterine infertility (no uterus or one that doesn't work) have a baby through a uterus transplant from a donor. Participants will first undergo IVF to create embryos, then receive the transplant, followed by embryo transfer and pregna…

This early-stage trial tests a drug called atipeksen for people with Ataxia-Telangiectasia (A-T), a rare genetic disease that affects movement and coordination. The drug is designed to fix a specific genetic error in the ATM gene and is given via spinal injection. The study will …

This study tests whether adding a hormone drug called Decapeptyl to standard IVF treatments can increase the number of live births. About 784 women under 43 with subfertility will receive either the drug or a placebo during egg retrieval and embryo transfer. The goal is to see if…

This study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…

This study tests whether a donated uterus can help 10 women who were born without a uterus or had it removed to carry a pregnancy. Participants will receive a uterus from a living or deceased donor, then try in vitro fertilization (IVF) to become pregnant. The goal is a live birt…

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This study tests whether giving platelet-rich plasma (PRP) inside the uterus can improve the immune environment and thickness of the lining in women undergoing IVF. Researchers will take biopsies before and after PRP to measure changes in immune cells. The goal is to see if PRP c…

This study tests whether removing tiny cell fragments from day-4 embryos (a procedure called defragmentation) can help them develop into healthy blastocysts and lead to more pregnancies. About 320 women undergoing IVF will be randomly assigned to have their embryos defragmented o…

This study looks at whether drinking a daily serving of gazpacho, a cold tomato-based soup, can improve semen quality in men with low sperm counts or poor sperm movement. Eighty men will follow a Mediterranean diet for 12 weeks, with half also drinking gazpacho each day. Research…

This program provides an experimental drug, levacetylleucine, to people with Ataxia-Telangiectasia (A-T), a rare genetic disease that affects movement and immunity. It is for patients who cannot join clinical trials and have no other good treatment options. The goal is to offer p…

This study tests a new drug called TCC1727 combined with other medicines (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors, including lung, stomach, endometrial cancer, and melanoma. The goal is to find the safest dose and see if the combination helps s…

This study offers girls facing fertility-threatening medical treatments the option to freeze their ovarian tissue for future use. Up to 40 participants will have a small piece of ovary removed laparoscopically and stored. The goal is to see how many choose this option and at what…

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study tests a milder form of IVF called CAPA in-vitro oocyte maturation (IVM). Instead of giving women strong hormones to stimulate egg growth, eggs are collected early and matured in a lab. The goal is to reduce side effects and costs for women with infertility or those pre…

This study tests whether taking a low dose of the hormone hCG for 8 weeks before IVF can increase the number of eggs retrieved in women with diminished ovarian reserve. About 80 women will be randomly assigned to receive either hCG or a placebo. The main goal is to see if hCG lea…

This study compares a single injection of corifollitropin alfa (Elonva) to daily shots of follitropin beta (Puregon) for ovarian stimulation in egg donors. Both groups also take medroxyprogesterone acetate to prevent early ovulation. The goal is to see if the simpler one-shot app…

This study is tracking 2,600 Chinese children with growth disorders who are receiving a long-acting growth hormone injection. The goal is to see how well it works and how safe it is over the long term in real-world settings. Researchers will measure changes in height and look for…

This study looks at two ways of taking progesterone for teens with Turner syndrome who are on hormone replacement therapy. One group takes progesterone for 12 days each month, the other takes it every day. Researchers will track bleeding patterns and how the teens feel, to see wh…

This study tests whether adding levothyroxine (a thyroid hormone) to the standard fertility drug letrozole helps women with PCOS and mild underactive thyroid ovulate and get pregnant. Two hundred women will be randomly assigned to receive either letrozole alone or letrozole plus …

This trial tests whether a 10-session group program called Social Management Training can improve mental health, executive function, and social skills in adults aged 16 to 69 who have sex chromosome aneuploidies (extra or missing sex chromosomes). Participants complete questionna…

This study will test whether a 21-day spa program can improve hormone levels and well-being in 55 women aged 20-40 with infertility. Participants will receive comprehensive spa care including treatments and rehabilitation. The goal is to see if this approach can help reduce stres…

This study compares two pain management plans after laparoscopic tubal sterilization: one with opioids and one without. About 38 women will report their pain levels and satisfaction. The goal is to see if non-opioid drugs like Tylenol and ibuprofen work just as well.

This study tests whether infusing platelet-rich plasma (PRP) into the uterus can thicken the uterine lining and improve pregnancy success in women with infertility who have had failed IVF cycles due to a thin lining. About 62 women will receive either PRP or a placebo during a fr…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether tadalafil, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility. About 100 women who have good-quality frozen embryos will take tadalafil before embryo transfer. The main goal i…

This study looks at whether a smartphone app with daily mindfulness exercises can help reduce anxiety and improve quality of life for women undergoing IVF. About 150 women will either use the app for 15 minutes a day or receive standard care. Researchers will measure anxiety, dep…

This study tests whether taking Gushen Antai pills, a blend of 10 herbs, can increase the chance of an ongoing pregnancy (past 12 weeks) in women with normal ovarian reserve who are undergoing IVF. 800 women will be randomly assigned to receive either the herbal pill or a placebo…

This study tests whether a 9-step mindset management program called Organic Conceptions can reduce stress in women struggling with infertility. About 66 new patients at a fertility clinic will either take the program or serve as a control group. Researchers will measure stress le…

This study looks at whether freezing ovarian tissue can help preserve fertility in people aged 2-21 with conditions like Turner syndrome, galactosemia, or premature ovarian insufficiency. Participants may have surgery to remove and freeze a gonad, with a small piece used for rese…

This study aims to create a large genetic database of people with Turner syndrome, a rare condition where a person is missing all or part of an X chromosome. Researchers want to compare the genes of women with Turner syndrome who are fertile with those who are not. Up to 500 part…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study investigates why women with obesity often have trouble ovulating. Researchers will give estradiol patches to 20 women with regular cycles and measure how their pituitary gland responds. The goal is to see if obesity dampens the brain's ability to trigger the hormone su…

This study tracks the long-term safety and effectiveness of the growth hormone treatment Growtropin-II in children with short stature. It includes up to 5,000 children with growth hormone deficiency, idiopathic short stature, Turner syndrome, or those born small for gestational a…

This study is looking at whether women with lower ovarian reserve (fewer eggs) have had more early miscarriages in the past. Researchers will measure ovarian reserve with a blood test (AMH) and an ultrasound (antral follicle count) in over 2,000 women seeking fertility care. This…

This study tracks immune-related substances in the blood of 40 women undergoing a frozen embryo transfer. Researchers want to see how these markers change before and after the transfer, and whether they relate to pregnancy success. The goal is to better understand the role of the…

This study follows women aged 18 to 44 who are trying to conceive at a fertility clinic. Researchers want to learn how lifestyle habits like sleep, nutrition, and physical activity before pregnancy affect the chances of having a baby. Participants will be followed for up to 25 ye…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study looks at whether measuring telomeres—parts of our cells linked to aging—can help explain why some women still can't get pregnant even after fertility treatments. Fifteen women aged 25 to 42 will get blood tests to check their biological age, then receive a personalized…

This study investigates whether blocking a protein called RANKL can help eggs mature and improve fertility treatments. Researchers will use denosumab, a drug already approved for osteoporosis, in lab studies with human and mouse eggs. The goal is to understand if RANKL manipulati…

This study aims to better understand cervical mucus and find biological markers that could help diagnose or predict reproductive problems like infertility. Researchers will use infrared spectroscopy to analyze mucus samples from 24 women—some healthy and some with unexplained inf…

This study looks at immune cells in the womb lining and blood of women with unexplained infertility or repeated miscarriages, compared to fertile women. Researchers want to see if differences in these cells help explain why some women have trouble getting pregnant. The study invo…

This study follows 60 girls and women with classic galactosemia, a rare genetic condition that affects how the body processes sugar. Researchers want to understand why many develop early ovarian failure and how puberty progresses. By tracking hormone levels and growth, they hope …

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study looks at how physical activity, fitness, stress, and sleep affect pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women aged 18-43 to see if being more active improves their chances of getting pregnant. The goal is to…

This study follows 93 women with Turner syndrome who wanted to become parents. Researchers will track how many succeeded through natural pregnancy, egg donation, or adoption. The goal is to understand the real-world chances of parenthood for these women.

This study looks at how women getting infertility treatment feel about artificial intelligence and how that relates to their anxiety and quality of life. About 191 women aged 18-45 who are currently undergoing treatment will answer surveys. The goal is to understand if attitudes …

This study watches blood sugar levels in 100 women getting fertility treatments like IVF. Participants wear a continuous glucose monitor to track sugar changes. The goal is to see if these changes affect pregnancy results. This is an observation-only study, not a treatment.

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols may be saf…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study looks at whether levels of Anti-Müllerian hormone (AMH) in the fluid around a woman's eggs can predict if an embryo has the right number of chromosomes. Researchers will collect fluid from one follicle in each ovary during egg retrieval in 300 women undergoing IVF. The…

This study looks at two ways to fertilize eggs with frozen donor sperm: ICSI (injecting a single sperm into an egg) and conventional IVF (mixing eggs and sperm in a dish). About 95 women without male fertility issues will have their eggs split into two groups, one fertilized with…