Female infertility

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This Phase 3 trial tested a treatment called EryDex for people with ataxia telangiectasia (A-T), a rare genetic disease that affects movement and coordination. EryDex is a steroid (dexamethasone) packaged inside the patient's own red blood cells and given as an IV infusion every …

This study looked at 99 IVF patients with endometriosis (a condition where uterine-like tissue grows elsewhere) and a positive BCL6 test. It compared a cheap oral pill (norethindrone acetate) to an expensive injection (Depo Lupron) given before embryo transfer. The goal was to se…

This study tested whether Erzhi Tiangui granules, a traditional Chinese herbal blend, could improve live birth rates in women aged 35 to 43 with poor ovarian response undergoing IVF. The trial involved 480 participants across multiple centers and compared the herbal granules to a…

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…

This study tested whether giving a small daily dose of a hormone (human menopausal gonadotropin) after egg retrieval could improve the chance of a live birth in women undergoing IVF. 600 women aged 20-40 took part. The researchers compared live birth rates between those who got t…

This completed Phase 3 trial compared two fertility drugs—follitropin delta (Rekovelle) and follitropin alfa (Gonal-F)—in 301 Chinese women undergoing IVF. The goal was to see which starting dose leads to the best number of eggs retrieved. Participants received daily injections f…

This study looked at whether adding vaginal estradiol or oral guaifenesin to standard fertility treatment (clomiphene citrate) could improve pregnancy rates. 90 women with infertility were randomly assigned to one of three groups. The goal was to see if these add-ons helped with …

This study tested whether two natural supplements (acetyl L-carnitine and myo/chiro-inositol) can help women with PCOS ovulate and become pregnant. 120 women aged 18-35 with PCOS-related infertility took part. The goal was to see if these supplements improve ovulation and pregnan…

This completed trial tested a new device called HyperSperm that prepares sperm for IVF or ICSI. Researchers compared it to standard sperm preparation in 41 couples. The goal was to see if the new method leads to more embryos reaching the blastocyst stage, which is key for success…

This study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…

This study tested whether postbiotic suppositories (containing natural bacteria byproducts) could improve the vaginal microbiome in 15 infertile women aged 30-45 who had at least two failed IVF attempts. Participants used one suppository daily for 8 weeks. Researchers measured ch…

This study tested a high dose of a fertility drug called follitropin delta, mixed with another hormone (hCG), in 118 women undergoing IVF. The goal was to see if this combination could improve the number of good-quality embryos. The study was completed and focused on women aged 1…

This study tested an experimental drug called AT-007 in 47 children aged 2 to 18 with Classic Galactosemia, a rare genetic disorder that makes it hard to break down a sugar called galactose. The goal was to see if the drug could improve behavior, daily living skills, and language…

This phase 3 trial tested whether an oral tablet called SHR7280 works as well as the standard injection (ganirelix) for preventing early ovulation in women undergoing IVF. The study involved 317 infertile women aged 20-39. If effective, the pill could offer a more convenient opti…

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study compared two imaging methods for diagnosing female infertility: MRI with a contrast dye and traditional X-ray. The goal was to see if MRI, which uses no radiation, could provide a complete and accurate assessment. Forty women participated, and researchers measured how …

This study tested a program called Babble Boot Camp for babies with classic galactosemia, a rare condition that often causes speech and language problems. The program started when babies were 2 to 24 months old and involved weekly online coaching for parents from a speech therapi…

This study tested whether a simple mindfulness exercise—noticing natural changes in mood and body throughout the day—could improve wellbeing for couples dealing with infertility. 70 patients and their partners took part. The goal was to see if this low-cost, easy-to-learn approac…

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation…

This study tested whether flushing follicles with a special needle during egg retrieval helps women who produce few eggs in IVF. 257 women with fewer than 5 mature follicles were randomly assigned to standard aspiration or aspiration plus flushing. The goal was to see if flushing…

This study tested whether a special supplement containing antioxidants and probiotics could improve egg quality in women with polycystic ovary syndrome (PCOS) undergoing IVF. Twenty women took either the supplement or a placebo (just folic acid) during their IVF cycle. Researcher…

This study looks at how sleep length and quality may affect the success of in vitro fertilization (IVF) in women. Participants will wear a ring-shaped device that tracks sleep patterns before and after a frozen embryo transfer. The goal is to see if sleep parameters like total sl…

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …

This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. Half received a mild stimulation (clomiphene plus low-dose hormones) and half received a stronger stimulation (higher-dose hormones). The goal was to see which approach led to more good-quality bla…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This early-stage study tested the safety and tolerability of a new drug called HS-10518 in 60 healthy premenopausal women in China. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The goal was…

This study looked at over 5,800 couples who had a first baby through fertility treatment at an Italian clinic. Researchers wanted to see how many came back for more treatment to have a second or third child, and what factors—like age or frozen embryos—affected that decision. The …

This study looked at whether the level of thyroid-stimulating hormone (TSH) in the blood affects the success of a fertility treatment called ICSI. Researchers measured TSH in 180 women on day 2-3 of their menstrual cycle and then tracked egg retrieval, fertilization, and pregnanc…

This study looked at over 1,800 frozen embryo transfer cycles to see if a woman's body mass index (BMI) affects whether the transfer can be done as planned and if it leads to pregnancy. Researchers compared obese and non-obese women using different hormone preparation methods. Th…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study compared two advanced embryo culture systems used in IVF with ICSI. One system has a built-in camera to watch embryos continuously, while the other uses periodic microscope checks. Researchers wanted to see if either system leads to more embryos implanting successfully…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This study looked at how different doses and methods of giving progesterone (vaginal, under the skin, or muscle injection) affect the structure and function of the uterine lining in women preparing for embryo transfer. 109 healthy women with regular cycles took part, and research…

This study looked at whether using a special freezing medium designed just for eggs, versus a universal medium for all stages, affects pregnancy rates in egg donation. Researchers analyzed data from 111 donor cycles. The goal is to see if the type of freezing medium makes a diffe…

This study looked at 255 women who chose to have permanent sterilization (tubal ligation) surgery. Researchers compared three different surgical approaches to see which one led to the best recovery and highest patient satisfaction. The goal was to help doctors and patients choose…

This study looked at over 1,200 women under 40 who had a frozen embryo transfer. Some used a natural cycle with no hormones, while others took estrogen and progesterone to mimic a natural cycle. The goal was to see which method leads to more pregnancies. Results could help clinic…

This study looked at 158 women having intrauterine insemination (IUI) to see if progesterone levels on the day of insemination are linked to pregnancy rates. IUI is a simpler, cheaper fertility treatment than IVF, but success rates are low. Researchers measured progesterone and o…

This study tested a robotic assistant to automate key steps in the IVF lab, such as preparing sperm and eggs, injecting sperm into eggs (ICSI), and freezing embryos. Researchers compared the robot's performance to standard manual methods using eggs and embryos from 42 couples und…

This study observed 201 women in Nordic countries and Switzerland who were using the fertility drug REKOVELLE® for the first time during IVF or ICSI. Researchers tracked how doctors prescribed the drug, including dose adjustments and use of a dosing app, to understand real-world …

This study looked at whether flushing the uterus with a low dose of the hormone hCG right after egg retrieval could improve pregnancy rates in women undergoing IVF. Researchers measured immune markers and blood flow in the uterus to see if the flush made the womb more receptive t…

This study looked at 87 women who had no eggs retrieved during their first IVF cycle. Researchers wanted to see if a second round of ovulation-inducing medication could lead to successful egg retrieval. The goal was to understand which factors might predict failure and how to imp…

This study looked at genes in cumulus cells (cells that surround eggs) from 137 women undergoing IVF. The goal was to find genetic markers that predict which embryos are most likely to lead to a pregnancy. Researchers compared two different hormone treatments to see if gene patte…