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Flushing technique may boost egg retrieval in women with low ovarian reserve

NCT ID NCT01329302

Symptom relief Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether flushing follicles with a special needle during egg retrieval helps women who produce few eggs in IVF. 257 women with fewer than 5 mature follicles were randomly assigned to standard aspiration or aspiration plus flushing. The goal was to see if flushing increases the number of mature eggs collected and improves pregnancy rates.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Follicular flushing with double lumen needle
What this could lead to
If successful, this technique could help women with low ovarian response retrieve more eggs during IVF, potentially increasing their chances of pregnancy.
What could go wrong
This is a completed study with 257 participants, but the benefit may be small and not apply to all patients. Flushing adds time and cost to the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

257 people

The number who actually took part.

Started

Mar 2011

Finished

Jun 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 43 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients undergoing an IVF or ICSI treatment * long agonist, antagonist or short stimulations protocols * less than 5 follicles of 14mm or more day of HCG * Major patients aged under 43 years * patient within a couple married or can prove a married life of over 2 years Exclusion Criteria: * all the cons indication to the oocyte retrieval * oocyte donor * Couple supported viral loop * Patient does not speak French or unable to give informed consent * Patients major protected * Patients with biopsy performed on weekends are also excluded due to unavailability of adequate personnel and equipment * Absence of follicles

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Conditions

The condition(s) this trial relates to.

female infertility ovarian dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility, female Ovarian insufficiency

Contacts and locations

Locations

  • Centre d'Assistance Médicale à la Procréation, CMCO-SIHCUS

    Schiltigheim, Schiltigheim, 67300, France

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