IVF Needle-Free? oral pill tested as injection alternative

NCT ID NCT07732348

First seen Jul 28, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This trial tests whether an oral medication called linzagolix can replace daily injections used to prevent premature ovulation during in vitro fertilization (IVF). The study compares the number of mature eggs retrieved in women taking the pill versus those receiving standard injectable drugs. A separate group using a different hormonal protocol is also included for comparison. The goal is to see if the oral option works just as well while being easier to take.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an oral GnRH antagonist called linzagolix, compared with injectable GnRH antagonists (ganirelix or cetrorelix)
What this could lead to
If it works, this could offer women undergoing IVF a simpler, needle-free option to prevent premature ovulation, potentially reducing stress and discomfort.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not be conclusive. Linzagolix is not yet approved for this use, and its effectiveness and safety in IVF are unproven.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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