Female infertility

This study tests a new way to prepare sperm for in vitro fertilization (IVF) called HyperSperm. It compares the safety and effectiveness of this method to standard sperm preparation. The trial will involve 202 couples undergoing IVF and will measure how many embryos are healthy (…

This phase 3 study tests a new weekly growth hormone injection (inpegsomatropin) against an existing one (givopegsomatropin) in 84 girls with Turner syndrome who have short stature. The goal is to see which works better for increasing growth over 52 weeks. Participants are prepub…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study tests whether infusing a woman's own platelet-rich plasma (PRP) into the uterus can improve the uterine lining in women with a thin or unresponsive endometrium and a history of failed embryo transfers. About 80 women will receive either standard hormone therapy alone o…

This study tests whether a modified dual trigger (a mix of HCG and two doses of a GnRH agonist) works better than the standard HCG trigger for ovulation in women undergoing IVF. About 196 women with normal egg reserves will participate. The goal is to see if the new method improv…

This study tests whether giving two medications (a GnRH agonist and HCG) instead of just HCG can help women with low ovarian response produce more mature eggs for IVF. About 164 women will be randomly assigned to receive either the double trigger or the standard HCG trigger. The …

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This study tests whether transplanting ovarian tissue from a sister can restore fertility and hormone production in women with premature ovarian failure (early menopause). Ten women will receive tissue from their non-identical sister, along with immunosuppressive drugs to prevent…

This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compa…

This study tests whether a lower daily dose (150 IU) of follicle-stimulating hormone (FSH) is as effective as a higher dose (225 IU) for women with normal ovarian reserve undergoing IVF. The main goal is to see if the lower dose leads to similar live birth rates while possibly re…

This early-stage study tests a new drug called YB-1113 for women with premature ovarian insufficiency (early menopause). The goal is to see if it is safe and can help restart ovarian function, potentially allowing women under 40 to become pregnant. Only 6 participants will receiv…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either PRP-treated sperm or standar…

This study will compare two advanced sperm selection techniques—PICSI and the ZyMot device—used during ICSI (a type of IVF). The goal is to see which method leads to more pregnancies. 300 couples will take part, with women aged 20-39. The results could help fertility clinics choo…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePr…

This study tests a web-based mind-body awareness program for women undergoing infertility treatment. The program includes education and relaxation practices over 3 sessions in 2 weeks. Researchers will measure if it improves fertility awareness and feelings of preparedness in 78 …

This pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…

This study looks at a fertility drug called corifollitropin alfa in women aged 36 to 40 who are doing IVF. The goal is to see if the drug is safe and helps produce eggs. Researchers will track side effects and pregnancy rates over one year.

This study will test whether a 21-day spa program can improve hormone levels and well-being in 55 women aged 20-40 with infertility. Participants will receive comprehensive spa care including treatments and rehabilitation. The goal is to see if this approach can help reduce stres…

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) increases the chance of pregnancy in women who also took letrozole to stimulate their ovaries. About 690 women in Denmark will be randomly assigned to receive either progesterone vagina…

This study looks at whether a gamified healthy lifestyle training program can help women going through fertility treatments (like IVF) adopt healthier habits and feel more in control. About 105 women will be split into three groups: one gets the game-like program plus a booklet, …

This study tests whether preparing the uterus for frozen embryo transfer with a completely natural cycle or a modified cycle (with ovulation-triggering medication) works better. It also looks at adding letrozole tablets early in the cycle. About 120 women undergoing IVF will be r…

This study tests whether intravenous lidocaine or magnesium sulfate can better stabilize blood pressure and heart rate as women wake up from general anesthesia during infertility-related laparoscopic surgery. Sixty-nine women will be randomly assigned to receive one of the two dr…

This study tests whether adding pure platelet-rich plasma (P-PRP) to sperm samples can improve sperm movement (motility) in a lab. Researchers will first standardize how to make P-PRP, then compare sperm quality after 24 hours with and without P-PRP. The trial involves 248 partic…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This study looks at women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs, making IVF harder. Researchers are examining specific RNA molecules in the fluid around eggs to see how they relate to egg quality and embryo development. The goal is …

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This study looks at whether transferring an embryo on day 2 or day 3 after fertilization leads to more live births in women aged 35 or older with low ovarian reserve. About 470 women will be randomly assigned to one of the two transfer times. The goal is to find out which timing …

This observational study looks at embryos from IVF that are not used for pregnancy to find molecular patterns related to embryo quality. Researchers hope to learn why some embryos are healthy and others are not, which could improve future fertility treatments. About 150 patients …

This study looks at how the size and number of ovarian follicles (fluid-filled sacs containing eggs) on the day of the trigger shot affect how many eggs are retrieved during an IVF cycle. Researchers will measure follicles using ultrasound in 60 women aged 18-35 undergoing ICSI. …

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study tests whether rinsing (flushing) ovarian follicles during egg retrieval can increase the number of mature eggs collected for IVF. In 75 women undergoing IVF, one ovary will be flushed and the other will not, and the egg yields will be compared. The goal is to see if th…

This study will test a computer model that predicts infertility risk in women with uterine fibroids. Researchers will follow over 7,000 women aged 20-50 who want to conceive and have fibroids. The goal is to see if the model can accurately identify who might struggle to get pregn…