Estrogen showdown: gel or pill for turner syndrome puberty?
NCT ID NCT07041814
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compare breast development, uterine growth, and side effects to see which method works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
estrogen (estradiol valerate tablets or estradiol gel)
What this could lead to
If successful, this trial could show which estrogen method (gel or tablet) is more effective and safer for starting puberty in girls with Turner syndrome, helping doctors choose the best treatment.
What could go wrong
This is a small early-phase trial with only 24 participants, so results may not apply to everyone. Both treatments are already used, so no major new risks are expected, but side effects like headaches or nausea are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital Canselor Tuanku Muhriz (HCTM)
Cheras, Kuala Lumpur, 56000, Malaysia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact