Estrogen showdown: gel or pill for turner syndrome puberty?

NCT ID NCT07041814

Not yet recruiting Disease control Sponsor: Universiti Kebangsaan Malaysia Medical Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compare breast development, uterine growth, and side effects to see which method works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: estrogen (estradiol valerate tablets or estradiol gel)
What this could lead to: If successful, this trial could show which estrogen method (gel or tablet) is more effective and safer for starting puberty in girls with Turner syndrome, helping doctors choose the best treatment.
What could go wrong: This is a small early-phase trial with only 24 participants, so results may not apply to everyone. Both treatments are already used, so no major new risks are expected, but side effects like headaches or nausea are possible.

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Conditions

The condition(s) this trial relates to.

Turner syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TURNER SYNDROME

Contacts and locations

Locations

Hospital Canselor Tuanku Muhriz (HCTM)

Cheras, Kuala Lumpur, 56000, Malaysia

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