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Can a growth factor infusion help women with thin uterine lining get pregnant?

NCT ID NCT07692672

Disease control Sponsor: Nanjing University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests whether a single infusion of granulocyte colony-stimulating factor (G-CSF) into the uterus can improve pregnancy outcomes in women with thin endometrium (uterine lining) undergoing frozen embryo transfer. Thin endometrium can reduce the chance of pregnancy. The study randomly assigns 620 women to receive either G-CSF or a saline placebo after mild uterine stimulation. The main goal is to see if G-CSF increases the live birth rate.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Granulocyte Colony-Stimulating Factor (G-CSF)
What this could lead to
If it works, this could offer a simple, low-cost way to improve live birth rates for women with thin endometrium undergoing IVF.
What could go wrong
This is a single-center trial, and results may not apply to all patients. G-CSF may not improve outcomes and could carry unknown risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 620 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18 to \<40 years. * Patients with normal ovarian function. * History of endometrial thickness ≤7 mm in at least one previous endometrial preparation cycle. * At least two good-quality embryos remaining. * Fewer than 3 previous embryo transfer cycles. * Willing and able to provide written informed consent. Exclusion Criteria: * Uterine diseases or conditions that may affect the uterine cavity, including intramural uterine fibroids affecting the uterine cavity, severe adenomyosis, endometriosis, uterine malformation, endometrial tuberculosis, or severe untreated intrauterine adhesions. * Endometrial lesions, history of pelvic tumors, or previous radiotherapy or chemotherapy. * Known allergy to G-CSF. * Current participation in another clinical study.

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Conditions

The condition(s) this trial relates to.

female infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Female infertility Thin endometrium

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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